| 08 Nov 20 | r54  | Inter de MadridInter de Madr | 1 - 0 | Las Rozas CFLas Rozas CF |
| 08 Nov 20 | r54 | Atlético Madrid BAtlético Madr | 1 - 2 | SS ReyesSS Reyes |
| 08 Nov 20 | r54 | VillarrobledoVillarrobledo | 0 - 1 | ExtremaduraExtremadura |
| 08 Nov 20 | r54 | PoblensePoblense | 0 - 0 | Getafe BGetafe B |
| 08 Nov 20 | r54 | Mérida ADMérida AD | 2 - 0 | MelillaMelilla |
| 08 Nov 20 | r54 | NavalcarneroNavalcarnero | 0 - 0 | Rayo MajadahondaRayo Majadaho |
| 08 Nov 20 | r54 | BadajozBadajoz | 2 - 0 | VillarrubiaVillarrubia |
| 08 Nov 20 | r54 | TalaveraTalavera | 1 - 1 | Don BenitoDon Benito |
| 08 Nov 20 | r54 | VillanovenseVillanovense | 2 - 0 | SocuéllamosSocuéllamos |
| 25 Nov 20 | r54 | Real Madrid BReal Madrid B | 1 - 1 | Atlético BalearesAtlético Bale |
| 24 Apr 21 | r54 | VillarrobledoVillarrobledo | 0 - 2 | Atlético Madrid BAtlético Madr |
| 24 Apr 21 | r54 | ExtremaduraExtremadura | 2 - 0 | Real Madrid BReal Madrid B |
| 24 Apr 21 | r54 | VillarrubiaVillarrubia | 1 - 0 | Getafe BGetafe B |
| 25 Apr 21 | r54 | Don BenitoDon Benito | 1 - 4 | Atlético BalearesAtlético Bale |
| 25 Apr 21 | r54 | SocuéllamosSocuéllamos | 1 - 0 | PoblensePoblense |
| 25 Apr 21 | r54 | MelillaMelilla | 0 - 0 | Las Rozas CFLas Rozas CF |
| 25 Apr 21 | r54 | TalaveraTalavera | 3 - 0 | SS ReyesSS Reyes |
| 25 Apr 21 | r54 | BadajozBadajoz | 1 - 0 | Inter de MadridInter de Madr |
| 25 Apr 21 | r54 | Mérida ADMérida AD | 1 - 1 | Rayo MajadahondaRayo Majadaho |
| 25 Apr 21 | r54 | VillanovenseVillanovense | 2 - 1 | NavalcarneroNavalcarnero |
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