| 24 Oct 20 | r52  | ExtremaduraExtremadura | 1 - 1 | VillarrubiaVillarrubia |
| 25 Oct 20 | r52 | Rayo MajadahondaRayo Majadaho | 2 - 0 | Atlético BalearesAtlético Bale |
| 25 Oct 20 | r52 | Real Madrid BReal Madrid B | 1 - 2 | Getafe BGetafe B |
| 25 Oct 20 | r52 | Inter de MadridInter de Madr | 3 - 1 | Atlético Madrid BAtlético Madr |
| 25 Oct 20 | r52 | TalaveraTalavera | 1 - 2 | MelillaMelilla |
| 25 Oct 20 | r52 | PoblensePoblense | 1 - 1 | SS ReyesSS Reyes |
| 25 Oct 20 | r52 | VillarrobledoVillarrobledo | 0 - 0 | SocuéllamosSocuéllamos |
| 25 Oct 20 | r52 | NavalcarneroNavalcarnero | 3 - 0 | Las Rozas CFLas Rozas CF |
| 25 Oct 20 | r52 | VillanovenseVillanovense | 0 - 0 | Mérida ADMérida AD |
| 25 Oct 20 | r52 | BadajozBadajoz | 2 - 0 | Don BenitoDon Benito |
| 10 Apr 21 | r52 | Don BenitoDon Benito | 1 - 2 | Rayo MajadahondaRayo Majadaho |
| 10 Apr 21 | r52 | VillarrubiaVillarrubia | 0 - 2 | Atlético Madrid BAtlético Madr |
| 11 Apr 21 | r52 | MelillaMelilla | 3 - 2 | PoblensePoblense |
| 11 Apr 21 | r52 | TalaveraTalavera | 2 - 0 | Inter de MadridInter de Madr |
| 11 Apr 21 | r52 | BadajozBadajoz | 2 - 0 | Real Madrid BReal Madrid B |
| 11 Apr 21 | r52 | VillanovenseVillanovense | 0 - 2 | Atlético BalearesAtlético Bale |
| 11 Apr 21 | r52 | SocuéllamosSocuéllamos | 1 - 0 | Las Rozas CFLas Rozas CF |
| 11 Apr 21 | r52 | VillarrobledoVillarrobledo | 1 - 1 | Getafe BGetafe B |
| 11 Apr 21 | r52 | ExtremaduraExtremadura | 0 - 0 | SS ReyesSS Reyes |
| 11 Apr 21 | r52 | Mérida ADMérida AD | 3 - 0 | NavalcarneroNavalcarnero |
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