| 30 Aug 22 | r01        | CarlisleCarlisle | 1 - 2 | Manchester United U21Manchester Un |
| |
| 30 Aug 22 | r03        | AccringtonAccrington | 3 - 3 | RochdaleRochdale |
| |
| 30 Aug 22 | r01        | AFC WimbledonAFC Wimbledon | 2 - 1 | Aston Villa U21Aston Villa U |
| 30 Aug 22 | r01        | Cambridge UnitedCambridge Uni | 0 - 2 | Arsenal U21Arsenal U21 |
| |
| 30 Aug 22 | r02        | Fleetwood TownFleetwood Tow | 1 - 1 | BarrowBarrow |
| 30 Aug 22 | r02        | ExeterExeter | 1 - 2 | NewportNewport |
| 30 Aug 22 | r02        | Forest Green RoversForest Green | 3 - 1 | Southampton U21Southampton U |
| 30 Aug 22 | r02        | SwindonSwindon | 0 - 2 | Crystal Palace U21Crystal Palac |
| 30 Aug 22 | r02        | PlymouthPlymouth | 1 - 1 | Bristol RoversBristol Rover |
| 30 Aug 22 | r02        | WycombeWycombe | 0 - 0 | Tottenham U21Tottenham U21 |
| 30 Aug 22 | r02        | WalsallWalsall | 0 - 1 | West Ham U21West Ham U21 |
| 30 Aug 22 | r02        | Milton Keynes DonsMilton Keynes | 1 - 2 | CheltenhamCheltenham |
| 30 Aug 22 | r02        | BurtonBurton | 4 - 2 | Leicester U21Leicester U21 |
| |
| 30 Aug 22 | r01        | MansfieldMansfield | 3 - 2 | Manchester City U21Manchester Ci |
| 30 Aug 22 | r01        | DerbyDerby | 3 - 1 | GrimsbyGrimsby |
| 30 Aug 22 | r01        | DoncasterDoncaster | 0 - 0 | Newcastle United U21Newcastle Uni |
| 30 Aug 22 | r01        | ShrewsburyShrewsbury | 1 - 2 | Wolves U21Wolves U21 |
| 30 Aug 22 | r01        | MorecambeMorecambe | 3 - 3 | Everton U21Everton U21 |
| 30 Aug 22 | r01        | HartlepoolHartlepool | 2 - 0 | Harrogate Town FCHarrogate Tow |
| |
| 30 Aug 22 | r03        | BoltonBolton | 4 - 1 | CreweCrewe |
| 30 Aug 22 | r03        | BradfordBradford | 3 - 1 | Sheffield WedsSheffield Wed |
| 30 Aug 22 | r03        | PeterboroPeterboro | 1 - 2 | StevenageStevenage |
| 30 Aug 22 | r03        | CarlisleCarlisle | 1 - 2 | Man Utd U21Man Utd U21 |
| |
| 30 Aug 22 | r02        | Port ValePort Vale | 1 - 0 | StockportStockport |
| |
| 30 Aug 22 | r03        | Salford CitySalford City | 2 - 1 | Liverpool U21Liverpool U21 |
| 30 Aug 22 | r03        | BarnsleyBarnsley | 0 - 3 | LincolnLincoln |
| 30 Aug 22 | r03        | CrawleyCrawley | 2 - 2 | PortsmouthPortsmouth |
| 30 Aug 22 | r03        | Oxford UtdOxford Utd | 5 - 0 | Leyton OrientLeyton Orient |
| |
| 30 Aug 22 | r04        | IpswichIpswich | 6 - 0 | NorthamptonNorthampton |
| 31 Aug 22 | r04        | CharltonCharlton | 3 - 0 | GillinghamGillingham |
| |
| 31 Aug 22 | r03        | Sutton UnitedSutton United | 1 - 0 | Chelsea U21Chelsea U21 |
| |
| 06 Sep 22 | r04        | ColchesterColchester | 2 - 1 | Brighton U21Brighton U21 |
| |
| 20 Sep 22 | r05        | LincolnLincoln | 1 - 2 | DoncasterDoncaster |
| |
| 20 Sep 22 | r01        | RochdaleRochdale | 1 - 0 | Liverpool U21Liverpool U21 |
| |
| 20 Sep 22 | r04        | ShrewsburyShrewsbury | 0 - 4 | Port ValePort Vale |
| 20 Sep 22 | r04        | Leyton OrientLeyton Orient | 3 - 1 | Sutton UnitedSutton United |
| |
| 20 Sep 22 | r05        | Sheffield WedsSheffield Wed | 2 - 3 | BurtonBurton |
| 20 Sep 22 | r05        | CheltenhamCheltenham | 2 - 1 | WalsallWalsall |
| 20 Sep 22 | r05        | CarlisleCarlisle | 1 - 1 | Fleetwood TownFleetwood Tow |
| 20 Sep 22 | r05        | SwindonSwindon | 1 - 3 | PlymouthPlymouth |
| |
| 20 Sep 22 | r06        | NorthamptonNorthampton | 0 - 2 | Cambridge UnitedCambridge Uni |
| |
| 20 Sep 22 | r05        | StevenageStevenage | 3 - 0 | WycombeWycombe |
| 20 Sep 22 | r05        | BarnsleyBarnsley | 2 - 0 | Newcastle United U21Newcastle Uni |
| 20 Sep 22 | r05        | TranmereTranmere | 2 - 2 | BoltonBolton |
| |
| 20 Sep 22 | r04        | MorecambeMorecambe | 0 - 0 | HartlepoolHartlepool |
| |
| 20 Sep 22 | r05        | Salford CitySalford City | 0 - 0 | AccringtonAccrington |
| |
| 20 Sep 22 | r06        | StockportStockport | 1 - 2 | Wolves U21Wolves U21 |
| 20 Sep 22 | r06        | GrimsbyGrimsby | 2 - 0 | MansfieldMansfield |
| 20 Sep 22 | r06        | PeterboroPeterboro | 3 - 0 | Tottenham U21Tottenham U21 |
| |
| 20 Sep 22 | r04        | IpswichIpswich | 2 - 0 | Arsenal U21Arsenal U21 |
| |
| 20 Sep 22 | r06        | NewportNewport | 1 - 2 | Forest Green RoversForest Green |
| 20 Sep 22 | r06        | AFC WimbledonAFC Wimbledon | 3 - 2 | CrawleyCrawley |
| |
| 04 Oct 22 | r07        | BarrowBarrow | 1 - 2 | Manchester United U21Manchester Un |
| |
| 04 Oct 22 | r01        | TranmereTranmere | 3 - 5 | Leeds United U21Leeds United |
| |
| 04 Oct 22 | r06        | ExeterExeter | 2 - 1 | Southampton U21Southampton U |
| 04 Oct 22 | r06        | Harrogate Town FCHarrogate Tow | 1 - 1 | Everton U21Everton U21 |
| 04 Oct 22 | r06        | GillinghamGillingham | 3 - 2 | Brighton U21Brighton U21 |
| 04 Oct 22 | r06        | Milton Keynes DonsMilton Keynes | 2 - 0 | West Ham U21West Ham U21 |
| |
| 04 Oct 22 | r07        | Bristol RoversBristol Rover | 2 - 0 | Crystal Palace U21Crystal Palac |
| |
| 04 Oct 22 | r08        | MansfieldMansfield | 1 - 1 | DerbyDerby |
| |
| 04 Oct 22 | r07        | BarrowBarrow | 1 - 2 | Man Utd U21Man Utd U21 |
| 04 Oct 22 | r07        | BradfordBradford | 2 - 2 | Leicester U21Leicester U21 |
| |
| 04 Oct 22 | r04        | PortsmouthPortsmouth | 5 - 0 | Aston Villa U21Aston Villa U |
| 04 Oct 22 | r04        | Oxford UtdOxford Utd | 1 - 2 | Chelsea U21Chelsea U21 |
| |
| 04 Oct 22 | r07        | ColchesterColchester | 2 - 1 | CharltonCharlton |
| 11 Oct 22 | r07        | DoncasterDoncaster | 2 - 4 | BarnsleyBarnsley |
| 11 Oct 22 | r07        | GillinghamGillingham | 1 - 1 | ColchesterColchester |
| |
| 18 Oct 22 | r08        | LincolnLincoln | 2 - 0 | Newcastle United U21Newcastle Uni |
| |
| 18 Oct 22 | r10        | AccringtonAccrington | 3 - 2 | Liverpool U21Liverpool U21 |
| |
| 18 Oct 22 | r08        | Fleetwood TownFleetwood Tow | 2 - 2 | Manchester United U21Manchester Un |
| |
| 18 Oct 22 | r05        | DerbyDerby | 1 - 3 | Manchester City U21Manchester Ci |
| |
| 18 Oct 22 | r08        | NorthamptonNorthampton | 1 - 3 | Arsenal U21Arsenal U21 |
| 18 Oct 22 | r08        | Leyton OrientLeyton Orient | 2 - 3 | Chelsea U21Chelsea U21 |
| |
| 18 Oct 22 | r09        | CheltenhamCheltenham | 1 - 2 | West Ham U21West Ham U21 |
| 18 Oct 22 | r09        | Cambridge UnitedCambridge Uni | 1 - 0 | IpswichIpswich |
| 18 Oct 22 | r09        | Bristol RoversBristol Rover | 3 - 0 | SwindonSwindon |
| 18 Oct 22 | r09        | PlymouthPlymouth | 1 - 0 | Crystal Palace U21Crystal Palac |
| 18 Oct 22 | r09        | WycombeWycombe | 1 - 1 | PeterboroPeterboro |
| 18 Oct 22 | r09        | StevenageStevenage | 1 - 0 | Tottenham U21Tottenham U21 |
| 18 Oct 22 | r09        | WalsallWalsall | 0 - 2 | Milton Keynes DonsMilton Keynes |
| 18 Oct 22 | r09        | Sheffield WedsSheffield Wed | 2 - 0 | Leicester U21Leicester U21 |
| |
| 18 Oct 22 | r08        | BurtonBurton | 4 - 0 | BradfordBradford |
| 18 Oct 22 | r08        | BarrowBarrow | 2 - 0 | CarlisleCarlisle |
| 18 Oct 22 | r08        | BoltonBolton | 3 - 0 | Leeds United U21Leeds United |
| 18 Oct 22 | r08        | CreweCrewe | 0 - 1 | TranmereTranmere |
| 18 Oct 22 | r08        | Harrogate Town FCHarrogate Tow | 2 - 1 | MorecambeMorecambe |
| 18 Oct 22 | r08        | HartlepoolHartlepool | 0 - 6 | Everton U21Everton U21 |
| |
| 18 Oct 22 | r10        | RochdaleRochdale | 2 - 2 | Salford CitySalford City |
| 18 Oct 22 | r10        | Forest Green RoversForest Green | 4 - 1 | ExeterExeter |
| |
| 18 Oct 22 | r09        | Port ValePort Vale | 2 - 0 | Wolves U21Wolves U21 |
| 18 Oct 22 | r09        | StockportStockport | 1 - 0 | ShrewsburyShrewsbury |
| |
| 18 Oct 22 | r07        | CrawleyCrawley | 5 - 2 | Aston Villa U21Aston Villa U |
| 18 Oct 22 | r07        | Fleetwood TownFleetwood Tow | 2 - 2 | Man Utd U21Man Utd U21 |
| |
| 18 Oct 22 | r10        | NewportNewport | 2 - 1 | Southampton U21Southampton U |
| 18 Oct 22 | r10        | Sutton UnitedSutton United | 2 - 0 | Oxford UtdOxford Utd |
| |
| 01 Nov 22 | r04        | CreweCrewe | 0 - 0 | Leeds United U21Leeds United |
| |
| 01 Nov 22 | r07        | PortsmouthPortsmouth | 1 - 1 | AFC WimbledonAFC Wimbledon |
| |
| 02 Nov 22 | r10        | CharltonCharlton | 2 - 1 | Brighton U21Brighton U21 |
| |
| 08 Nov 22 | r07        | GrimsbyGrimsby | 1 - 1 | Manchester City U21Manchester Ci |
| |
| 22 Nov 22 | r00        | Manchester United U21Manchester Un | 0 - 0 | Wolves U21Wolves U21 |
| 22 Nov 22 | r00        | BurtonBurton | 1 - 1 | TranmereTranmere |
| 22 Nov 22 | r00        | LincolnLincoln | 1 - 1 | MorecambeMorecambe |
| 22 Nov 22 | r00        | StevenageStevenage | 3 - 2 | Arsenal U21Arsenal U21 |
| 22 Nov 22 | r00        | Milton Keynes DonsMilton Keynes | 3 - 1 | NewportNewport |
| 22 Nov 22 | r00        | Forest Green RoversForest Green | 1 - 1 | CheltenhamCheltenham |
| 22 Nov 22 | r00        | PlymouthPlymouth | 3 - 2 | CharltonCharlton |
| |
| 22 Nov 22 | r02        | Wolves U21Wolves U21 | 0 - 0 | Manchester United U21Manchester Un |
| |
| 22 Nov 22 | r00        | Salford CitySalford City | 1 - 0 | BradfordBradford |
| 22 Nov 22 | r00        | GrimsbyGrimsby | 0 - 1 | AccringtonAccrington |
| 22 Nov 22 | r00        | Chelsea U21Chelsea U21 | 2 - 4 | PeterboroPeterboro |
| |
| 22 Nov 22 | r02        | PeterboroPeterboro | 2 - 4 | Chelsea U21Chelsea U21 |
| |
| 22 Nov 22 | r00        | BoltonBolton | 3 - 2 | BarrowBarrow |
| 22 Nov 22 | r00        | AFC WimbledonAFC Wimbledon | 1 - 0 | Sutton UnitedSutton United |
| 22 Nov 22 | r00        | IpswichIpswich | 0 - 2 | PortsmouthPortsmouth |
| 23 Nov 22 | r00        | Port ValePort Vale | 2 - 1 | BarnsleyBarnsley |
| 23 Nov 22 | r00        | ColchesterColchester | 1 - 2 | Bristol RoversBristol Rover |
| 30 Nov 22 | r00        | Everton U21Everton U21 | 2 - 1 | MansfieldMansfield |
| 13 Dec 22 | r00        | BurtonBurton | 2 - 4 | AccringtonAccrington |
| 13 Dec 22 | r00        | PortsmouthPortsmouth | 3 - 0 | StevenageStevenage |
| 13 Dec 22 | r00        | CheltenhamCheltenham | 4 - 0 | Chelsea U21Chelsea U21 |
| 13 Dec 22 | r00        | LincolnLincoln | 4 - 2 | Everton U21Everton U21 |
| 13 Dec 22 | r00        | Bristol RoversBristol Rover | 4 - 1 | Milton Keynes DonsMilton Keynes |
| 13 Dec 22 | r00        | BoltonBolton | 4 - 0 | Manchester United U21Manchester Un |
| 20 Dec 22 | r00        | Salford CitySalford City | 1 - 0 | Port ValePort Vale |
| 21 Dec 22 | r00        | PlymouthPlymouth | 3 - 3 | AFC WimbledonAFC Wimbledon |
| 10 Jan 23 | r00        | LincolnLincoln | 2 - 2 | AccringtonAccrington |
| 10 Jan 23 | r00        | BoltonBolton | 1 - 0 | PortsmouthPortsmouth |
| 10 Jan 23 | r00        | Bristol RoversBristol Rover | 0 - 2 | PlymouthPlymouth |
| 10 Jan 23 | r00        | CheltenhamCheltenham | 3 - 1 | Salford CitySalford City |
| 21 Feb 23 | r00        | PlymouthPlymouth | 1 - 1 | CheltenhamCheltenham |
| 22 Feb 23 | r00        | AccringtonAccrington | 0 - 2 | BoltonBolton |
| 02 Apr 23 | r00        | BoltonBolton | 4 - 0 | PlymouthPlymouth |