| 16 Oct 21 | r01        | ES ZarzisES Zarzis | 0 - 2 | Olympique BéjaOlympique Béj |
| |
| 23 Oct 21 | r02        | CS ChebbaCS Chebba | 0 - 0 | ES ZarzisES Zarzis |
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| 30 Oct 21 | r03        | ES ZarzisES Zarzis | 0 - 0 | RejicheRejiche |
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| 04 Nov 21 | r04        | Étoile Sportive du SahelÉtoile Sporti | 1 - 1 | ES ZarzisES Zarzis |
| |
| 07 Nov 21 | r05        | ES ZarzisES Zarzis | 0 - 0 | AS SolimanAS Soliman |
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| 18 Nov 21 | r06        | Club AfricainClub Africain | 1 - 0 | ES ZarzisES Zarzis |
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| 21 Nov 21 | r07        | ES ZarzisES Zarzis | 0 - 1 | US MonastirUS Monastir |
| |
| 20 Feb 22 | r08        | Olympique BéjaOlympique Béj | 0 - 1 | ES ZarzisES Zarzis |
| |
| 26 Feb 22 | r09        | ES ZarzisES Zarzis | 2 - 1 | CS ChebbaCS Chebba |
| |
| 09 Mar 22 | r10        | RejicheRejiche | 1 - 0 | ES ZarzisES Zarzis |
| |
| 16 Mar 22 | r11        | ES ZarzisES Zarzis | 0 - 3 | Étoile Sportive du SahelÉtoile Sporti |
| |
| 06 Apr 22 | r12        | AS SolimanAS Soliman | 2 - 1 | ES ZarzisES Zarzis |
| |
| 10 Apr 22 | r13        | ES ZarzisES Zarzis | 0 - 1 | Club AfricainClub Africain |
| |
| 13 Apr 22 | r14        | US MonastirUS Monastir | 0 - 1 | ES ZarzisES Zarzis |
| |
| 07 May 22 | r01        | Olympique BéjaOlympique Béj | 3 - 0 | ES ZarzisES Zarzis |
| |
| 14 May 22 | r02        | ES ZarzisES Zarzis | 1 - 1 | ES MétlaouiES Métlaoui |
| |
| 18 May 22 | r03        | Hammam-SousseHammam-Sousse | 1 - 1 | ES ZarzisES Zarzis |
| |
| 23 May 22 | r04        | ES ZarzisES Zarzis | 1 - 0 | Olympique BéjaOlympique Béj |
| |
| 26 May 22 | r05        | ES MétlaouiES Métlaoui | 1 - 0 | ES ZarzisES Zarzis |
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| 29 May 22 | r06        | ES ZarzisES Zarzis | 1 - 1 | Hammam-SousseHammam-Sousse |