| 19 Dec 21 | r01        | EnyimbaEnyimba | 2 - 1 | Abia WarriorsAbia Warriors |
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| 26 Dec 21 | r02        | Rangers InternationalRangers Inter | 0 - 1 | EnyimbaEnyimba |
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| 29 Dec 21 | r03        | EnyimbaEnyimba | 0 - 1 | Rivers UnitedRivers United |
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| 02 Jan 22 | r04        | Kano PillarsKano Pillars | 2 - 0 | EnyimbaEnyimba |
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| 09 Jan 22 | r05        | EnyimbaEnyimba | 1 - 0 | Shooting StarsShooting Star |
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| 16 Jan 22 | r06        | Gombe UnitedGombe United | 0 - 0 | EnyimbaEnyimba |
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| 23 Jan 22 | r08        | Lobi StarsLobi Stars | 1 - 0 | EnyimbaEnyimba |
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| 26 Jan 22 | r07        | EnyimbaEnyimba | 1 - 0 | Akwa UnitedAkwa United |
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| 29 Jan 22 | r09        | EnyimbaEnyimba | 2 - 1 | Katsina UnitedKatsina Unite |
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| 02 Feb 22 | r10        | Nasarawa UnitedNasarawa Unit | 2 - 1 | EnyimbaEnyimba |
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| 06 Feb 22 | r11        | Sunshine StarsSunshine Star | 0 - 1 | EnyimbaEnyimba |
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| 12 Feb 22 | r12        | EnyimbaEnyimba | 1 - 1 | Niger TornadoesNiger Tornado |
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| 16 Feb 22 | r13        | Kwara UnitedKwara United | 1 - 0 | EnyimbaEnyimba |
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| 19 Feb 22 | r14        | EnyimbaEnyimba | 1 - 1 | MFMMFM |
| 19 Feb 22 | r14        | EnyimbaEnyimba | 1 - 1 | MFMMFM |
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| 26 Feb 22 | r15        | HeartlandHeartland | 1 - 0 | EnyimbaEnyimba |
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| 02 Mar 22 | r16        | EnyimbaEnyimba | 2 - 1 | Remo StarsRemo Stars |
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| 06 Mar 22 | r17        | DakkadaDakkada | 2 - 0 | EnyimbaEnyimba |
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| 12 Mar 22 | r18        | EnyimbaEnyimba | 1 - 1 | Plateau UnitedPlateau Unite |
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| 20 Mar 22 | r19        | Wikki TouristsWikki Tourist | 0 - 0 | EnyimbaEnyimba |
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| 03 Apr 22 | r20        | EnyimbaEnyimba | 2 - 0 | Wikki TouristsWikki Tourist |
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| 06 Apr 22 | r21        | Abia WarriorsAbia Warriors | 2 - 1 | EnyimbaEnyimba |
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| 10 Apr 22 | r22        | EnyimbaEnyimba | 2 - 1 | Rangers InternationalRangers Inter |
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| 18 Apr 22 | r23        | Rivers UnitedRivers United | 2 - 0 | EnyimbaEnyimba |
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| 21 Apr 22 | r24        | EnyimbaEnyimba | 4 - 0 | Kano PillarsKano Pillars |
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| 25 Apr 22 | r25        | Shooting StarsShooting Star | 2 - 0 | EnyimbaEnyimba |
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| 30 Apr 22 | r26        | EnyimbaEnyimba | 3 - 0 | Gombe UnitedGombe United |
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| 08 May 22 | r27        | Akwa UnitedAkwa United | 1 - 1 | EnyimbaEnyimba |
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| 14 May 22 | r28        | EnyimbaEnyimba | 2 - 1 | Lobi StarsLobi Stars |
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| 22 May 22 | r29        | Katsina UnitedKatsina Unite | 1 - 0 | EnyimbaEnyimba |
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| 28 May 22 | r30        | EnyimbaEnyimba | 3 - 2 | Nasarawa UnitedNasarawa Unit |
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| 01 Jun 22 | r31        | EnyimbaEnyimba | 2 - 0 | Sunshine StarsSunshine Star |
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| 05 Jun 22 | r32        | Niger TornadoesNiger Tornado | 2 - 1 | EnyimbaEnyimba |
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| 12 Jun 22 | r33        | EnyimbaEnyimba | 3 - 0 | Kwara UnitedKwara United |
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| 19 Jun 22 | r34        | MFMMFM | 2 - 1 | EnyimbaEnyimba |
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| 26 Jun 22 | r35        | EnyimbaEnyimba | 0 - 0 | HeartlandHeartland |
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| 03 Jul 22 | r36        | Remo StarsRemo Stars | 1 - 0 | EnyimbaEnyimba |
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| 10 Jul 22 | r37        | EnyimbaEnyimba | 0 - 2 | DakkadaDakkada |
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| 17 Jul 22 | r38        | Plateau UnitedPlateau Unite | 1 - 0 | EnyimbaEnyimba |