| 15 Jan 22 | r06        | Akwa UnitedAkwa United | 2 - 0 | Katsina UnitedKatsina Unite |
| 16 Jan 22 | r06        | Gombe UnitedGombe United | 0 - 0 | EnyimbaEnyimba |
| 16 Jan 22 | r06        | Abia WarriorsAbia Warriors | 1 - 0 | HeartlandHeartland |
| 16 Jan 22 | r06        | Plateau UnitedPlateau Unite | 5 - 0 | DakkadaDakkada |
| 16 Jan 22 | r06        | Shooting StarsShooting Star | 2 - 2 | Sunshine StarsSunshine Star |
| 16 Jan 22 | r06        | Rivers UnitedRivers United | 3 - 0 | Kwara UnitedKwara United |
| 16 Jan 22 | r06        | Nasarawa UnitedNasarawa Unit | 2 - 1 | Lobi StarsLobi Stars |
| 16 Jan 22 | r06        | Kano PillarsKano Pillars | 1 - 0 | Niger TornadoesNiger Tornado |
| 16 Jan 22 | r06        | Wikki TouristsWikki Tourist | 1 - 2 | Remo StarsRemo Stars |
| 16 Jan 22 | r06        | Rangers InternationalRangers Inter | 2 - 0 | MFMMFM |