| 02 Jan 22 | r04        | Nasarawa UnitedNasarawa Unit | 2 - 0 | Akwa UnitedAkwa United |
| 02 Jan 22 | r04        | DakkadaDakkada | 1 - 1 | Remo StarsRemo Stars |
| 02 Jan 22 | r04        | Wikki TouristsWikki Tourist | 3 - 0 | MFMMFM |
| 02 Jan 22 | r04        | Rivers UnitedRivers United | 0 - 0 | Sunshine StarsSunshine Star |
| 02 Jan 22 | r04        | Kano PillarsKano Pillars | 2 - 0 | EnyimbaEnyimba |
| 02 Jan 22 | r04        | Rangers InternationalRangers Inter | 4 - 0 | Niger TornadoesNiger Tornado |
| 02 Jan 22 | r04        | Plateau UnitedPlateau Unite | 3 - 0 | HeartlandHeartland |
| 03 Jan 22 | r04        | Gombe UnitedGombe United | 3 - 0 | Lobi StarsLobi Stars |
| 03 Jan 22 | r04        | Abia WarriorsAbia Warriors | 1 - 1 | Kwara UnitedKwara United |
| 03 Jan 22 | r04        | Shooting StarsShooting Star | 1 - 0 | Katsina UnitedKatsina Unite |