| 06 Jun 21 |
r25        | Katsina UnitedKatsina Unite | 2 - 1 | Nasarawa UnitedNasarawa Unit |
| 06 Jun 21 |
r25        | Adamawa UnitedAdamawa Unite | 0 - 2 | Plateau UnitedPlateau Unite |
| 06 Jun 21 |
r25        | HeartlandHeartland | 2 - 2 | Rivers UnitedRivers United |
| 06 Jun 21 |
r25        | Wikki TouristsWikki Tourist | 2 - 2 | Akwa UnitedAkwa United |
| 06 Jun 21 |
r25        | Kwara UnitedKwara United | 3 - 0 | Jigawa Golden StarsJigawa Golden |
| 06 Jun 21 |
r25        | Abia WarriorsAbia Warriors | 1 - 1 | Ifeanyi UbahIfeanyi Ubah |
| 06 Jun 21 |
r25        | Rangers InternationalRangers Inter | 1 - 1 | MFMMFM |
| 06 Jun 21 |
r25        | Warri WolvesWarri Wolves | 2 - 1 | Sunshine StarsSunshine Star |