| 08 May 21 |
r20        | Jigawa Golden StarsJigawa Golden | 2 - 1 | Lobi StarsLobi Stars |
| 09 May 21 |
r20        | Akwa UnitedAkwa United | 2 - 1 | Sunshine StarsSunshine Star |
| 09 May 21 |
r20        | Rivers UnitedRivers United | 2 - 0 | DakkadaDakkada |
| 09 May 21 |
r20        | EnyimbaEnyimba | 2 - 0 | Rangers InternationalRangers Inter |
| 09 May 21 |
r20        | Plateau UnitedPlateau Unite | 2 - 1 | Abia WarriorsAbia Warriors |
| 09 May 21 |
r20        | Nasarawa UnitedNasarawa Unit | 2 - 1 | Kwara UnitedKwara United |
| 09 May 21 |
r20        | Katsina UnitedKatsina Unite | 5 - 1 | Wikki TouristsWikki Tourist |
| 09 May 21 |
r20        | Adamawa UnitedAdamawa Unite | 0 - 1 | HeartlandHeartland |
| 17 Jun 21 |
r20        | EnyimbaEnyimba | 2 - 1 | Rangers InternationalRangers Inter |