| 24 Feb 21 |
r12        | Plateau UnitedPlateau Unite | 3 - 0 | Jigawa Golden StarsJigawa Golden |
| 24 Feb 21 |
r12        | Nasarawa UnitedNasarawa Unit | 3 - 0 | Ifeanyi UbahIfeanyi Ubah |
| 24 Feb 21 |
r12        | Kano PillarsKano Pillars | 1 - 0 | Sunshine StarsSunshine Star |
| 24 Feb 21 |
r12        | Wikki TouristsWikki Tourist | 2 - 1 | Rangers InternationalRangers Inter |
| 24 Feb 21 |
r12        | Kwara UnitedKwara United | 1 - 1 | Abia WarriorsAbia Warriors |
| 24 Feb 21 |
r12        | Warri WolvesWarri Wolves | 1 - 0 | Rivers UnitedRivers United |
| 25 Feb 21 |
r12        | Katsina UnitedKatsina Unite | 0 - 0 | MFMMFM |
| 25 Feb 21 |
r12        | Adamawa UnitedAdamawa Unite | 1 - 0 | Lobi StarsLobi Stars |