| 20 Feb 21 |
r11        | Akwa UnitedAkwa United | 1 - 0 | Plateau UnitedPlateau Unite |
| 21 Feb 21 |
r11        | Jigawa Golden StarsJigawa Golden | 1 - 0 | Nasarawa UnitedNasarawa Unit |
| 21 Feb 21 |
r11        | Ifeanyi UbahIfeanyi Ubah | 3 - 0 | Katsina UnitedKatsina Unite |
| 21 Feb 21 |
r11        | MFMMFM | 2 - 0 | Adamawa UnitedAdamawa Unite |
| 21 Feb 21 |
r11        | Sunshine StarsSunshine Star | 1 - 1 | HeartlandHeartland |
| 21 Feb 21 |
r11        | Rangers InternationalRangers Inter | 1 - 0 | Kwara UnitedKwara United |
| 21 Feb 21 |
r11        | Abia WarriorsAbia Warriors | 4 - 1 | Warri WolvesWarri Wolves |
| 03 Mar 21 |
r11        | DakkadaDakkada | 2 - 1 | Wikki TouristsWikki Tourist |
| 02 May 21 |
r11        | Rivers UnitedRivers United | 1 - 0 | EnyimbaEnyimba |