| 18 Jan 25 | r01  | CD UniversitarioCD Universita | 1 - 1 | San Francisco FCSan Francisco |
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| 25 Jan 25 | r02 | Independiente de La ChorrIndependiente | 1 - 0 | San Francisco FCSan Francisco |
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| 04 Feb 25 | r03 | San Francisco FCSan Francisco | 0 - 2 | UMECITUMECIT |
| |
| 09 Feb 25 | r04 | HerreraHerrera | 0 - 1 | San Francisco FCSan Francisco |
| |
| 18 Feb 25 | r12 | Veraguas UnitedVeraguas Unit | 0 - 0 | San Francisco FCSan Francisco |
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| 22 Feb 25 | r06 | San Francisco FCSan Francisco | 1 - 1 | Tauro FCTauro FC |
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| 26 Feb 25 | r07 | San Francisco FCSan Francisco | 0 - 1 | Plaza AmadorPlaza Amador |
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| 11 Mar 25 | r08 | Potros del EstePotros del Es | 0 - 1 | San Francisco FCSan Francisco |
| |
| 15 Mar 25 | r09 | Sporting San MiguelitoSporting San | 0 - 1 | San Francisco FCSan Francisco |
| |
| 23 Mar 25 | r10 | Deportivo Árabe UnidoDeportivo Ára | 1 - 3 | San Francisco FCSan Francisco |
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| 29 Mar 25 | r11 | San Francisco FCSan Francisco | 1 - 2 | AlianzaAlianza |
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| 05 Apr 25 | r05 | San Francisco FCSan Francisco | 4 - 0 | Veraguas UnitedVeraguas Unit |
| |
| 12 Apr 25 | r13 | San Francisco FCSan Francisco | 1 - 1 | HerreraHerrera |
| |
| 26 Apr 25 | r14 | San Francisco FCSan Francisco | 1 - 1 | Independiente de La ChorrIndependiente |
| |
| 03 May 25 | r15 | UMECITUMECIT | 2 - 0 | San Francisco FCSan Francisco |
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| 10 May 25 | r16 | San Francisco FCSan Francisco | 3 - 0 | CD UniversitarioCD Universita |
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| 14 May 25 | r00 | Sporting San MiguelitoSporting San | 1 - 2 | San Francisco FCSan Francisco |
| 17 May 25 | r00 | San Francisco FCSan Francisco | 1 - 1 | CD UniversitarioCD Universita |
| 24 May 25 | r00 | CD UniversitarioCD Universita | 1 - 2 | San Francisco FCSan Francisco |
| 31 May 25 | r00 | Plaza AmadorPlaza Amador | 6 - 0 | San Francisco FCSan Francisco |
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| 26 Jul 25 | r02 | San Francisco FCSan Francisco | 1 - 2 | CD UniversitarioCD Universita |
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| 02 Aug 25 | r03 | San Francisco FCSan Francisco | 3 - 2 | Independiente de La ChorrIndependiente |
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| 10 Aug 25 | r04 | HerreraHerrera | 0 - 1 | San Francisco FCSan Francisco |
| |
| 16 Aug 25 | r05 | Veraguas UnitedVeraguas Unit | 2 - 3 | San Francisco FCSan Francisco |
| |
| 31 Aug 25 | r06 | Plaza AmadorPlaza Amador | 2 - 2 | San Francisco FCSan Francisco |
| |
| 06 Sep 25 | r07 | San Francisco FCSan Francisco | 0 - 0 | UMECITUMECIT |
| |
| 16 Sep 25 | r08 | AlianzaAlianza | 1 - 1 | San Francisco FCSan Francisco |
| |
| 20 Sep 25 | r09 | San Francisco FCSan Francisco | 0 - 1 | Sporting San MiguelitoSporting San |
| |
| 27 Sep 25 | r10 | San Francisco FCSan Francisco | 0 - 2 | Deportivo Árabe UnidoDeportivo Ára |
| |
| 04 Oct 25 | r11 | Tauro FCTauro FC | 1 - 1 | San Francisco FCSan Francisco |
| |
| 18 Oct 25 | r13 | CD UniversitarioCD Universita | 0 - 0 | San Francisco FCSan Francisco |
| |
| 25 Oct 25 | r14 | San Francisco FCSan Francisco | 1 - 0 | HerreraHerrera |
| |
| 31 Oct 25 | r15 | Independiente de La ChorrIndependiente | 0 - 0 | San Francisco FCSan Francisco |
| |
| 08 Nov 25 | r16 | San Francisco FCSan Francisco | 3 - 0 | Veraguas UnitedVeraguas Unit |
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| 16 Nov 25 | r00 | AlianzaAlianza | 1 - 1 | San Francisco FCSan Francisco |
| 22 Nov 25 | r00 | San Francisco FCSan Francisco | 1 - 2 | AlianzaAlianza |
Team 2025 Schedules
Alianza
CD Universitario
Deportivo Árabe Unido
Herrera
Independiente de La Chorrera
Plaza Amador
San Francisco FC
Sporting San Miguelito
Tauro
UMECIT
Unión Coclé
Veraguas United
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