| 05 Feb 22 | r01  | Tauro FCTauro FC | 3 - 3 | Sporting San MiguelitoSporting San |
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| 12 Feb 22 | r02 | Sporting San MiguelitoSporting San | 1 - 1 | Plaza AmadorPlaza Amador |
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| 20 Feb 22 | r03 | Árabe UnidoÁrabe Unido | 0 - 0 | Sporting San MiguelitoSporting San |
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| 27 Feb 22 | r04 | AlianzaAlianza | 0 - 1 | Sporting San MiguelitoSporting San |
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| 05 Mar 22 | r05 | Sporting San MiguelitoSporting San | 1 - 1 | Costa del EsteCosta del Est |
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| 08 Mar 22 | r06 | CD UniversitarioCD Universita | 0 - 2 | Sporting San MiguelitoSporting San |
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| 13 Mar 22 | r07 | Sporting San MiguelitoSporting San | 1 - 1 | HerreraHerrera |
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| 19 Mar 22 | r08 | VeraguasVeraguas | 1 - 2 | Sporting San MiguelitoSporting San |
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| 26 Mar 22 | r09 | San Francisco FCSan Francisco | 0 - 1 | Sporting San MiguelitoSporting San |
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| 04 Apr 22 | r10 | Sporting San MiguelitoSporting San | 4 - 1 | Atlético ChiriquíAtlético Chir |
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| 09 Apr 22 | r11 | Sporting San MiguelitoSporting San | 2 - 1 | Independiente de La ChorrIndependiente |
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| 23 Apr 22 | r13 | Plaza AmadorPlaza Amador | 1 - 1 | Sporting San MiguelitoSporting San |
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| 27 Apr 22 | r14 | Sporting San MiguelitoSporting San | 1 - 0 | Árabe UnidoÁrabe Unido |
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| 30 Apr 22 | r15 | Sporting San MiguelitoSporting San | 1 - 0 | AlianzaAlianza |
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| 04 May 22 | r12 | Sporting San MiguelitoSporting San | 0 - 1 | Tauro FCTauro FC |
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| 07 May 22 | r16 | Costa del EsteCosta del Est | 0 - 3 | Sporting San MiguelitoSporting San |
| |
| 16 May 22 | r00 | Tauro FCTauro FC | 1 - 2 | Sporting San MiguelitoSporting San |
| 23 May 22 | r00 | Sporting San MiguelitoSporting San | 0 - 0 | Tauro FCTauro FC |
| 29 May 22 | r00 | Sporting San MiguelitoSporting San | 1 - 2 | AlianzaAlianza |
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| 23 Jul 22 | r01 | Sporting San MiguelitoSporting San | 0 - 1 | AlianzaAlianza |
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| 31 Jul 22 | r02 | Plaza AmadorPlaza Amador | 1 - 1 | Sporting San MiguelitoSporting San |
| |
| 08 Aug 22 | r03 | Sporting San MiguelitoSporting San | 0 - 0 | Árabe UnidoÁrabe Unido |
| |
| 11 Aug 22 | r04 | Sporting San MiguelitoSporting San | 3 - 1 | Tauro FCTauro FC |
| |
| 14 Aug 22 | r05 | Costa del EsteCosta del Est | 1 - 3 | Sporting San MiguelitoSporting San |
| |
| 21 Aug 22 | r06 | Sporting San MiguelitoSporting San | 2 - 2 | CD UniversitarioCD Universita |
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| 28 Aug 22 | r07 | HerreraHerrera | 0 - 0 | Sporting San MiguelitoSporting San |
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| 03 Sep 22 | r08 | Sporting San MiguelitoSporting San | 3 - 2 | VeraguasVeraguas |
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| 12 Sep 22 | r09 | Sporting San MiguelitoSporting San | 2 - 1 | San Francisco FCSan Francisco |
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| 18 Sep 22 | r10 | Atlético ChiriquíAtlético Chir | 0 - 0 | Sporting San MiguelitoSporting San |
| |
| 24 Sep 22 | r11 | Independiente de La ChorrIndependiente | 0 - 2 | Sporting San MiguelitoSporting San |
| |
| 28 Sep 22 | r12 | AlianzaAlianza | 1 - 0 | Sporting San MiguelitoSporting San |
| |
| 02 Oct 22 | r13 | Sporting San MiguelitoSporting San | 1 - 1 | Plaza AmadorPlaza Amador |
| |
| 08 Oct 22 | r14 | Árabe UnidoÁrabe Unido | 1 - 1 | Sporting San MiguelitoSporting San |
| |
| 17 Oct 22 | r15 | Tauro FCTauro FC | 2 - 0 | Sporting San MiguelitoSporting San |
| |
| 22 Oct 22 | r16 | Sporting San MiguelitoSporting San | 3 - 2 | Costa del EsteCosta del Est |
| |
| 26 Oct 22 | r00 | Sporting San MiguelitoSporting San | 2 - 0 | San Francisco FCSan Francisco |
| 30 Oct 22 | r00 | Sporting San MiguelitoSporting San | 1 - 1 | Independiente de La ChorrIndependiente |
| 06 Nov 22 | r00 | Independiente de La ChorrIndependiente | 1 - 0 | Sporting San MiguelitoSporting San |
Team 2022 Schedules
Alianza
CD Universitario
Deportivo Árabe Unido
Herrera
Independiente de La Chorrera
Plaza Amador
San Francisco FC
Sporting San Miguelito
Tauro
UMECIT
Unión Coclé
Veraguas United
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