| 06 Feb 22 | r01  | Árabe UnidoÁrabe Unido | 0 - 1 | AlianzaAlianza |
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| 13 Feb 22 | r02 | Tauro FCTauro FC | 0 - 1 | AlianzaAlianza |
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| 20 Feb 22 | r03 | AlianzaAlianza | 0 - 0 | Costa del EsteCosta del Est |
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| 27 Feb 22 | r04 | AlianzaAlianza | 0 - 1 | Sporting San MiguelitoSporting San |
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| 05 Mar 22 | r05 | Plaza AmadorPlaza Amador | 0 - 0 | AlianzaAlianza |
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| 10 Mar 22 | r06 | AlianzaAlianza | 2 - 0 | VeraguasVeraguas |
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| 13 Mar 22 | r07 | AlianzaAlianza | 2 - 1 | San Francisco FCSan Francisco |
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| 20 Mar 22 | r08 | HerreraHerrera | 0 - 0 | AlianzaAlianza |
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| 26 Mar 22 | r09 | AlianzaAlianza | 2 - 0 | CD UniversitarioCD Universita |
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| 03 Apr 22 | r10 | Independiente de La ChorrIndependiente | 1 - 2 | AlianzaAlianza |
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| 10 Apr 22 | r11 | Atlético ChiriquíAtlético Chir | 1 - 1 | AlianzaAlianza |
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| 23 Apr 22 | r13 | AlianzaAlianza | 0 - 1 | Tauro FCTauro FC |
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| 26 Apr 22 | r14 | Costa del EsteCosta del Est | 1 - 2 | AlianzaAlianza |
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| 30 Apr 22 | r15 | Sporting San MiguelitoSporting San | 1 - 0 | AlianzaAlianza |
| |
| 04 May 22 | r12 | AlianzaAlianza | 2 - 0 | Árabe UnidoÁrabe Unido |
| |
| 08 May 22 | r16 | AlianzaAlianza | 0 - 0 | Plaza AmadorPlaza Amador |
| |
| 11 May 22 | r00 | AlianzaAlianza | 2 - 0 | HerreraHerrera |
| 15 May 22 | r00 | AlianzaAlianza | 1 - 0 | Atlético ChiriquíAtlético Chir |
| 22 May 22 | r00 | Atlético ChiriquíAtlético Chir | 1 - 1 | AlianzaAlianza |
| 29 May 22 | r00 | Sporting San MiguelitoSporting San | 1 - 2 | AlianzaAlianza |
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| 23 Jul 22 | r01 | Sporting San MiguelitoSporting San | 0 - 1 | AlianzaAlianza |
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| 30 Jul 22 | r02 | AlianzaAlianza | 0 - 0 | Tauro FCTauro FC |
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| 07 Aug 22 | r03 | Costa del EsteCosta del Est | 2 - 1 | AlianzaAlianza |
| |
| 10 Aug 22 | r04 | AlianzaAlianza | 0 - 3 | Árabe UnidoÁrabe Unido |
| |
| 14 Aug 22 | r05 | AlianzaAlianza | 1 - 3 | Plaza AmadorPlaza Amador |
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| 21 Aug 22 | r06 | VeraguasVeraguas | 0 - 1 | AlianzaAlianza |
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| 29 Aug 22 | r07 | San Francisco FCSan Francisco | 0 - 1 | AlianzaAlianza |
| |
| 04 Sep 22 | r08 | AlianzaAlianza | 1 - 1 | HerreraHerrera |
| |
| 11 Sep 22 | r09 | CD UniversitarioCD Universita | 1 - 0 | AlianzaAlianza |
| |
| 18 Sep 22 | r10 | AlianzaAlianza | 0 - 1 | Independiente de La ChorrIndependiente |
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| 25 Sep 22 | r11 | AlianzaAlianza | 4 - 0 | Atlético ChiriquíAtlético Chir |
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| 28 Sep 22 | r12 | AlianzaAlianza | 1 - 0 | Sporting San MiguelitoSporting San |
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| 02 Oct 22 | r13 | Tauro FCTauro FC | 0 - 2 | AlianzaAlianza |
| |
| 08 Oct 22 | r14 | AlianzaAlianza | 1 - 0 | Costa del EsteCosta del Est |
| |
| 16 Oct 22 | r15 | Árabe UnidoÁrabe Unido | 3 - 0 | AlianzaAlianza |
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| 22 Oct 22 | r16 | Plaza AmadorPlaza Amador | 1 - 1 | AlianzaAlianza |
Team 2022 Schedules
Alianza
CD Universitario
Deportivo Árabe Unido
Herrera
Independiente de La Chorrera
Plaza Amador
San Francisco FC
Sporting San Miguelito
Tauro
UMECIT
Unión Coclé
Veraguas United
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