| 21 Feb 21 | r01  | AlianzaAlianza | 0 - 0 | Sporting San MiguelitoSporting San |
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| 28 Feb 21 | r02 | Sporting San MiguelitoSporting San | 0 - 0 | Plaza AmadorPlaza Amador |
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| 07 Mar 21 | r03 | Tauro FCTauro FC | 0 - 1 | Sporting San MiguelitoSporting San |
| |
| 13 Mar 21 | r04 | Costa del EsteCosta del Est | 1 - 1 | Sporting San MiguelitoSporting San |
| |
| 18 Mar 21 | r05 | Sporting San MiguelitoSporting San | 3 - 2 | Árabe UnidoÁrabe Unido |
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| 21 Mar 21 | r06 | CD UniversitarioCD Universita | 2 - 1 | Sporting San MiguelitoSporting San |
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| 24 Mar 21 | r07 | Sporting San MiguelitoSporting San | 1 - 3 | Independiente de La ChorrIndependiente |
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| 10 Apr 21 | r10 | San Francisco FCSan Francisco | 2 - 0 | Sporting San MiguelitoSporting San |
| |
| 17 Apr 21 | r11 | Sporting San MiguelitoSporting San | 2 - 1 | Atlético ChiriquíAtlético Chir |
| |
| 20 Apr 21 | r12 | Sporting San MiguelitoSporting San | 0 - 0 | AlianzaAlianza |
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| 25 Apr 21 | r13 | Plaza AmadorPlaza Amador | 2 - 1 | Sporting San MiguelitoSporting San |
| |
| 28 Apr 21 | r14 | Sporting San MiguelitoSporting San | 2 - 2 | Tauro FCTauro FC |
| |
| 06 May 21 | r15 | Sporting San MiguelitoSporting San | 1 - 0 | Costa del EsteCosta del Est |
| |
| 09 May 21 | r16 | Árabe UnidoÁrabe Unido | 1 - 2 | Sporting San MiguelitoSporting San |
| |
| 13 May 21 | r00 | Independiente de La ChorrIndependiente | 0 - 0 | Sporting San MiguelitoSporting San |
| 17 May 21 | r00 | Sporting San MiguelitoSporting San | 0 - 1 | Plaza AmadorPlaza Amador |
| 22 May 21 | r00 | Plaza AmadorPlaza Amador | 1 - 0 | Sporting San MiguelitoSporting San |
| 24 May 21 | r00 | Plaza AmadorPlaza Amador | 1 - 1 | Sporting San MiguelitoSporting San |
| |
| 08 Aug 21 | r01 | Sporting San MiguelitoSporting San | 1 - 2 | AlianzaAlianza |
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| 15 Aug 21 | r02 | Plaza AmadorPlaza Amador | 0 - 0 | Sporting San MiguelitoSporting San |
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| 21 Aug 21 | r03 | Sporting San MiguelitoSporting San | 1 - 0 | Tauro FCTauro FC |
| |
| 29 Aug 21 | r04 | Sporting San MiguelitoSporting San | 1 - 1 | Costa del EsteCosta del Est |
| |
| 04 Sep 21 | r05 | Árabe UnidoÁrabe Unido | 0 - 1 | Sporting San MiguelitoSporting San |
| |
| 12 Sep 21 | r06 | Sporting San MiguelitoSporting San | 1 - 0 | CD UniversitarioCD Universita |
| |
| 17 Sep 21 | r07 | Independiente de La ChorrIndependiente | 3 - 0 | Sporting San MiguelitoSporting San |
| |
| 09 Oct 21 | r10 | Sporting San MiguelitoSporting San | 1 - 1 | San Francisco FCSan Francisco |
| |
| 17 Oct 21 | r11 | Atlético ChiriquíAtlético Chir | 1 - 1 | Sporting San MiguelitoSporting San |
| |
| 23 Oct 21 | r12 | AlianzaAlianza | 1 - 0 | Sporting San MiguelitoSporting San |
| |
| 31 Oct 21 | r13 | Sporting San MiguelitoSporting San | 1 - 1 | Plaza AmadorPlaza Amador |
| |
| 07 Nov 21 | r14 | Tauro FCTauro FC | 1 - 0 | Sporting San MiguelitoSporting San |
| |
| 13 Nov 21 | r15 | Costa del EsteCosta del Est | 1 - 0 | Sporting San MiguelitoSporting San |
| |
| 20 Nov 21 | r16 | Sporting San MiguelitoSporting San | 1 - 2 | Árabe UnidoÁrabe Unido |
Team 2021 Schedules
Alianza
CD Universitario
Deportivo Árabe Unido
Herrera
Independiente de La Chorrera
Plaza Amador
San Francisco FC
Sporting San Miguelito
Tauro
UMECIT
Unión Coclé
Veraguas United
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