| 27 Sep 20 | r01  | Lobos UPNFMLobos UPNFM | 2 - 3 | MotaguaMotagua |
| |
| 08 Oct 20 | r02 | Real Sociedad TocoaReal Sociedad | 2 - 3 | Lobos UPNFMLobos UPNFM |
| |
| 11 Oct 20 | r03 | CD OlimpiaCD Olimpia | 3 - 1 | Lobos UPNFMLobos UPNFM |
| |
| 15 Oct 20 | r04 | Lobos UPNFMLobos UPNFM | 2 - 2 | Real de MinasReal de Minas |
| |
| 19 Oct 20 | r05 | Honduras ProgresoHonduras Prog | 2 - 3 | Lobos UPNFMLobos UPNFM |
| |
| 25 Oct 20 | r07 | Lobos UPNFMLobos UPNFM | 1 - 1 | Real Sociedad TocoaReal Sociedad |
| |
| 29 Oct 20 | r08 | Lobos UPNFMLobos UPNFM | 1 - 1 | CD OlimpiaCD Olimpia |
| |
| 31 Oct 20 | r09 | Real de MinasReal de Minas | 1 - 1 | Lobos UPNFMLobos UPNFM |
| |
| 15 Nov 20 | r13 | Lobos UPNFMLobos UPNFM | 1 - 1 | Real EspañaReal España |
| |
| 23 Nov 20 | r10 | Lobos UPNFMLobos UPNFM | 0 - 1 | Honduras ProgresoHonduras Prog |
| |
| 25 Nov 20 | r11 | Lobos UPNFMLobos UPNFM | 0 - 2 | CD MarathónCD Marathón |
| |
| 30 Nov 20 | r12 | Platense Puerto CortésPlatense Puer | 1 - 1 | Lobos UPNFMLobos UPNFM |
| |
| 06 Dec 20 | r06 | MotaguaMotagua | 0 - 1 | Lobos UPNFMLobos UPNFM |
| |
| 12 Dec 20 | r14 | VidaVida | 0 - 3 | Lobos UPNFMLobos UPNFM |
| 12 Dec 20 | r14 | VidaVida | 0 - 3 | Lobos UPNFMLobos UPNFM |
| |
| 19 Dec 20 | r00 | Lobos UPNFMLobos UPNFM | 1 - 3 | VidaVida |
| 23 Dec 20 | r00 | VidaVida | 5 - 1 | Lobos UPNFMLobos UPNFM |
| |
| 16 Feb 21 | r01 | Lobos UPNFMLobos UPNFM | 1 - 2 | MotaguaMotagua |
| |
| 25 Feb 21 | r03 | CD OlimpiaCD Olimpia | 5 - 1 | Lobos UPNFMLobos UPNFM |
| |
| 27 Feb 21 | r04 | Lobos UPNFMLobos UPNFM | 2 - 0 | Real de MinasReal de Minas |
| |
| 04 Mar 21 | r05 | Honduras ProgresoHonduras Prog | 0 - 3 | Lobos UPNFMLobos UPNFM |
| |
| 07 Mar 21 | r06 | MotaguaMotagua | 3 - 1 | Lobos UPNFMLobos UPNFM |
| |
| 16 Mar 21 | r08 | Lobos UPNFMLobos UPNFM | 2 - 1 | CD OlimpiaCD Olimpia |
| |
| 20 Mar 21 | r09 | Real de MinasReal de Minas | 0 - 3 | Lobos UPNFMLobos UPNFM |
| |
| 24 Mar 21 | r02 | Real Sociedad TocoaReal Sociedad | 1 - 1 | Lobos UPNFMLobos UPNFM |
| |
| 29 Mar 21 | r07 | Lobos UPNFMLobos UPNFM | 1 - 2 | Real Sociedad TocoaReal Sociedad |
| |
| 01 Apr 21 | r10 | Lobos UPNFMLobos UPNFM | 0 - 2 | Honduras ProgresoHonduras Prog |
| |
| 09 Apr 21 | r11 | CD MarathónCD Marathón | 1 - 1 | Lobos UPNFMLobos UPNFM |
| |
| 18 Apr 21 | r12 | Lobos UPNFMLobos UPNFM | 0 - 0 | Platense Puerto CortésPlatense Puer |
| |
| 22 Apr 21 | r13 | Real EspañaReal España | 1 - 1 | Lobos UPNFMLobos UPNFM |
| |
| 28 Apr 21 | r14 | Lobos UPNFMLobos UPNFM | 3 - 1 | VidaVida |
| |
| 02 May 21 | r00 | Lobos UPNFMLobos UPNFM | 3 - 2 | Honduras ProgresoHonduras Prog |
| 06 May 21 | r00 | Honduras ProgresoHonduras Prog | 4 - 0 | Lobos UPNFMLobos UPNFM |
Team 2020-2021 Schedules
CD Olimpia
CD Victoria
Choloma
Génesis
Juticalpa
Lobos UPNFM
Marathón
Motagua
Olancho
Real España
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