| 28 Sep 20 | r01  | Real EspañaReal España | 1 - 1 | CD OlimpiaCD Olimpia |
| |
| 07 Oct 20 | r02 | Platense Puerto CortésPlatense Puer | 1 - 0 | Real EspañaReal España |
| |
| 12 Oct 20 | r03 | Real EspañaReal España | 5 - 0 | Honduras ProgresoHonduras Prog |
| |
| 14 Oct 20 | r04 | CD MarathónCD Marathón | 3 - 0 | Real EspañaReal España |
| |
| 19 Oct 20 | r05 | Real EspañaReal España | 0 - 3 | VidaVida |
| |
| 26 Oct 20 | r07 | Real EspañaReal España | 3 - 2 | Platense Puerto CortésPlatense Puer |
| |
| 29 Oct 20 | r08 | Honduras ProgresoHonduras Prog | 0 - 3 | Real EspañaReal España |
| |
| 01 Nov 20 | r09 | Real EspañaReal España | 0 - 1 | CD MarathónCD Marathón |
| |
| 15 Nov 20 | r13 | Lobos UPNFMLobos UPNFM | 1 - 1 | Real EspañaReal España |
| |
| 21 Nov 20 | r10 | VidaVida | 2 - 2 | Real EspañaReal España |
| |
| 26 Nov 20 | r11 | Real EspañaReal España | 1 - 1 | Real de MinasReal de Minas |
| 26 Nov 20 | r11 | Real EspañaReal España | 1 - 1 | Real de MinasReal de Minas |
| |
| 29 Nov 20 | r12 | Real EspañaReal España | 0 - 1 | MotaguaMotagua |
| |
| 07 Dec 20 | r06 | CD OlimpiaCD Olimpia | 1 - 0 | Real EspañaReal España |
| |
| 12 Dec 20 | r14 | Real Sociedad TocoaReal Sociedad | 1 - 2 | Real EspañaReal España |
| 12 Dec 20 | r14 | Real Sociedad TocoaReal Sociedad | 1 - 2 | Real EspañaReal España |
| |
| 18 Feb 21 | r01 | Real EspañaReal España | 1 - 2 | CD OlimpiaCD Olimpia |
| |
| 25 Feb 21 | r03 | Real EspañaReal España | 1 - 0 | Honduras ProgresoHonduras Prog |
| |
| 27 Feb 21 | r04 | CD MarathónCD Marathón | 1 - 2 | Real EspañaReal España |
| |
| 05 Mar 21 | r05 | Real EspañaReal España | 0 - 0 | VidaVida |
| |
| 08 Mar 21 | r06 | CD OlimpiaCD Olimpia | 1 - 0 | Real EspañaReal España |
| |
| 12 Mar 21 | r07 | Real EspañaReal España | 4 - 0 | Platense Puerto CortésPlatense Puer |
| |
| 18 Mar 21 | r08 | Honduras ProgresoHonduras Prog | 1 - 1 | Real EspañaReal España |
| |
| 21 Mar 21 | r09 | Real EspañaReal España | 2 - 2 | CD MarathónCD Marathón |
| |
| 04 Apr 21 | r10 | VidaVida | 2 - 3 | Real EspañaReal España |
| |
| 08 Apr 21 | r02 | Platense Puerto CortésPlatense Puer | 2 - 2 | Real EspañaReal España |
| |
| 12 Apr 21 | r11 | Real de MinasReal de Minas | 0 - 0 | Real EspañaReal España |
| |
| 18 Apr 21 | r12 | MotaguaMotagua | 1 - 0 | Real EspañaReal España |
| |
| 22 Apr 21 | r13 | Real EspañaReal España | 1 - 1 | Lobos UPNFMLobos UPNFM |
| |
| 28 Apr 21 | r14 | Real EspañaReal España | 0 - 0 | Real Sociedad TocoaReal Sociedad |
| |
| 02 May 21 | r00 | Real EspañaReal España | 0 - 0 | CD OlimpiaCD Olimpia |
| 06 May 21 | r00 | CD OlimpiaCD Olimpia | 2 - 1 | Real EspañaReal España |
| 09 May 21 | r00 | MotaguaMotagua | 1 - 0 | Real EspañaReal España |
| 13 May 21 | r00 | Real EspañaReal España | 1 - 0 | MotaguaMotagua |
Team 2020-2021 Schedules
CD Olimpia
CD Victoria
Choloma
Génesis
Juticalpa
Lobos UPNFM
Marathón
Motagua
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