| 01 Aug 21 | r01  | Nueva ConcepciónNueva Concepc | 0 - 0 | AchuapaAchuapa |
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| 07 Aug 21 | r02 | AchuapaAchuapa | 0 - 0 | MalacatecoMalacateco |
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| 11 Aug 21 | r03 | AchuapaAchuapa | 1 - 3 | ComunicacionesComunicacione |
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| 14 Aug 21 | r04 | Cobán ImperialCobán Imperia | 2 - 0 | AchuapaAchuapa |
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| 21 Aug 21 | r05  | AchuapaAchuapa | 0 - 1 | Antigua GFCAntigua GFC |
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| 25 Aug 21 | r06 | CD GuastatoyaCD Guastatoya | 2 - 2 | AchuapaAchuapa |
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| 29 Aug 21 | r07 | AchuapaAchuapa | 0 - 2 | Santa LuciaSanta Lucia |
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| 11 Sep 21 | r09 | AchuapaAchuapa | 2 - 0 | IztapaIztapa |
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| 15 Sep 21 | r10 | XelajúXelajú | 1 - 1 | AchuapaAchuapa |
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| 25 Sep 21 | r11 | AchuapaAchuapa | 0 - 2 | SololáSololá |
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| 29 Sep 21 | r08 | MunicipalMunicipal | 1 - 0 | AchuapaAchuapa |
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| 03 Oct 21 | r12 | AchuapaAchuapa | 1 - 0 | Nueva ConcepciónNueva Concepc |
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| 10 Oct 21 | r13 | MalacatecoMalacateco | 1 - 0 | AchuapaAchuapa |
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| 17 Oct 21 | r14 | ComunicacionesComunicacione | 0 - 0 | AchuapaAchuapa |
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| 23 Oct 21 | r15 | AchuapaAchuapa | 1 - 0 | Cobán ImperialCobán Imperia |
| |
| 28 Oct 21 | r16 | Antigua GFCAntigua GFC | 2 - 1 | AchuapaAchuapa |
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| 31 Oct 21 | r17 | AchuapaAchuapa | 0 - 0 | CD GuastatoyaCD Guastatoya |
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| 06 Nov 21 | r18 | Santa LuciaSanta Lucia | 0 - 0 | AchuapaAchuapa |
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| 14 Nov 21 | r19 | AchuapaAchuapa | 0 - 1 | MunicipalMunicipal |
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| 20 Nov 21 | r20 | IztapaIztapa | 3 - 2 | AchuapaAchuapa |
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| 28 Nov 21 | r21 | AchuapaAchuapa | 0 - 1 | XelajúXelajú |
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| 05 Dec 21 | r22 | SololáSololá | 2 - 1 | AchuapaAchuapa |
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| 16 Jan 22 | r01 | Antigua GFCAntigua GFC | 1 - 0 | AchuapaAchuapa |
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| 23 Jan 22 | r02 | AchuapaAchuapa | 0 - 3 | Santa LuciaSanta Lucia |
| |
| 30 Jan 22 | r03 | CD GuastatoyaCD Guastatoya | 2 - 0 | AchuapaAchuapa |
| |
| 02 Feb 22 | r04 | AchuapaAchuapa | 1 - 0 | SololáSololá |
| |
| 06 Feb 22 | r05 | ComunicacionesComunicacione | 2 - 1 | AchuapaAchuapa |
| |
| 09 Feb 22 | r06 | AchuapaAchuapa | 2 - 1 | MalacatecoMalacateco |
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| 13 Feb 22 | r07 | XelajúXelajú | 1 - 0 | AchuapaAchuapa |
| |
| 20 Feb 22 | r08 | AchuapaAchuapa | 1 - 1 | Nueva ConcepciónNueva Concepc |
| |
| 27 Feb 22 | r09 | Cobán ImperialCobán Imperia | 0 - 1 | AchuapaAchuapa |
| |
| 02 Mar 22 | r10 | AchuapaAchuapa | 0 - 0 | IztapaIztapa |
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| 05 Mar 22 | r11 | MunicipalMunicipal | 0 - 1 | AchuapaAchuapa |
| |
| 13 Mar 22 | r12 | AchuapaAchuapa | 1 - 1 | Antigua GFCAntigua GFC |
| |
| 20 Mar 22 | r13 | Santa LuciaSanta Lucia | 2 - 0 | AchuapaAchuapa |
| |
| 27 Mar 22 | r14 | AchuapaAchuapa | 1 - 0 | CD GuastatoyaCD Guastatoya |
| |
| 03 Apr 22 | r15 | SololáSololá | 1 - 1 | AchuapaAchuapa |
| |
| 10 Apr 22 | r16 | AchuapaAchuapa | 1 - 0 | ComunicacionesComunicacione |
| |
| 17 Apr 22 | r17 | MalacatecoMalacateco | 0 - 0 | AchuapaAchuapa |
| |
| 20 Apr 22 | r18 | AchuapaAchuapa | 2 - 1 | XelajúXelajú |
| |
| 24 Apr 22 | r19 | Nueva ConcepciónNueva Concepc | 1 - 1 | AchuapaAchuapa |
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| 01 May 22 | r20 | AchuapaAchuapa | 3 - 0 | Cobán ImperialCobán Imperia |
| |
| 04 May 22 | r21 | IztapaIztapa | 3 - 2 | AchuapaAchuapa |
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| 08 May 22 | r22 | AchuapaAchuapa | 0 - 0 | MunicipalMunicipal |
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| 11 May 22 | r00 | AchuapaAchuapa | 0 - 1 | MunicipalMunicipal |
| 14 May 22 | r00 | MunicipalMunicipal | 2 - 0 | AchuapaAchuapa |
Team 2021-2022 Schedules
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