| 01 Aug 21 | r01   | Once DeportivoOnce Deportiv | 2 - 2 | CD ÁguilaCD Águila |
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| 08 Aug 21 | r02 | JocoroJocoro | 3 - 4 | Once DeportivoOnce Deportiv |
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| 11 Aug 21 | r03 | Once DeportivoOnce Deportiv | 4 - 1 | LimeñoLimeño |
| |
| 15 Aug 21 | r04 | Platense Puerto CortésPlatense Puer | 1 - 1 | Once DeportivoOnce Deportiv |
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| 25 Aug 21 | r06 | FirpoFirpo | 2 - 2 | Once DeportivoOnce Deportiv |
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| 29 Aug 21 | r07 | ChalatenangoChalatenango | 1 - 2 | Once DeportivoOnce Deportiv |
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| 10 Sep 21 | r16 | Alianza FCAlianza FC | 1 - 0 | Once DeportivoOnce Deportiv |
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| 12 Sep 21 | r08 | Once DeportivoOnce Deportiv | 1 - 3 | FASFAS |
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| 16 Sep 21 | r09 | Isidro MetapánIsidro Metapá | 0 - 1 | Once DeportivoOnce Deportiv |
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| 19 Sep 21 | r10 | Once DeportivoOnce Deportiv | 0 - 0 | Atlético MarteAtlético Mart |
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| 26 Sep 21 | r11 | Santa Tecla FCSanta Tecla F | 0 - 1 | Once DeportivoOnce Deportiv |
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| 03 Oct 21 | r12 | CD ÁguilaCD Águila | 1 - 2 | Once DeportivoOnce Deportiv |
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| 09 Oct 21 | r14 | LimeñoLimeño | 1 - 1 | Once DeportivoOnce Deportiv |
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| 17 Oct 21 | r13 | Once DeportivoOnce Deportiv | 2 - 2 | JocoroJocoro |
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| 24 Oct 21 | r15 | Once DeportivoOnce Deportiv | 1 - 1 | Platense Puerto CortésPlatense Puer |
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| 30 Oct 21 | r05 | Once DeportivoOnce Deportiv | 2 - 3 | Alianza FCAlianza FC |
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| 02 Nov 21 | r17 | Once DeportivoOnce Deportiv | 1 - 0 | FirpoFirpo |
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| 07 Nov 21 | r18 | Once DeportivoOnce Deportiv | 1 - 2 | ChalatenangoChalatenango |
| |
| 14 Nov 21 | r19 | FASFAS | 3 - 2 | Once DeportivoOnce Deportiv |
| |
| 18 Nov 21 | r20 | Once DeportivoOnce Deportiv | 1 - 1 | Isidro MetapánIsidro Metapá |
| |
| 21 Nov 21 | r21 | Atlético MarteAtlético Mart | 1 - 4 | Once DeportivoOnce Deportiv |
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| 27 Nov 21 | r22 | Once DeportivoOnce Deportiv | 4 - 3 | Santa Tecla FCSanta Tecla F |
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| 02 Dec 21 | r00 | CD ÁguilaCD Águila | 1 - 1 | Once DeportivoOnce Deportiv |
| 05 Dec 21 | r00 | Once DeportivoOnce Deportiv | 0 - 0 | CD ÁguilaCD Águila |
| 08 Dec 21 | r00 | Once DeportivoOnce Deportiv | 1 - 1 | Alianza FCAlianza FC |
| 12 Dec 21 | r00 | Alianza FCAlianza FC | 2 - 0 | Once DeportivoOnce Deportiv |
| |
| 16 Jan 22 | r01 | Once DeportivoOnce Deportiv | 1 - 1 | FASFAS |
| |
| 23 Jan 22 | r02 | Santa Tecla FCSanta Tecla F | 1 - 1 | Once DeportivoOnce Deportiv |
| |
| 26 Jan 22 | r03 | Once DeportivoOnce Deportiv | 3 - 2 | LimeñoLimeño |
| |
| 29 Jan 22 | r04 | Atlético MarteAtlético Mart | 1 - 1 | Once DeportivoOnce Deportiv |
| |
| 06 Feb 22 | r05 | Once DeportivoOnce Deportiv | 0 - 0 | Isidro MetapánIsidro Metapá |
| |
| 10 Feb 22 | r06 | ChalatenangoChalatenango | 1 - 0 | Once DeportivoOnce Deportiv |
| |
| 13 Feb 22 | r07 | Once DeportivoOnce Deportiv | 1 - 0 | FirpoFirpo |
| |
| 20 Feb 22 | r08 | Platense Puerto CortésPlatense Puer | 1 - 0 | Once DeportivoOnce Deportiv |
| |
| 23 Feb 22 | r20 | Once DeportivoOnce Deportiv | 1 - 2 | Alianza FCAlianza FC |
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| 27 Feb 22 | r10 | Once DeportivoOnce Deportiv | 1 - 4 | CD ÁguilaCD Águila |
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| 05 Mar 22 | r11 | JocoroJocoro | 2 - 1 | Once DeportivoOnce Deportiv |
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| 13 Mar 22 | r12 | FASFAS | 0 - 0 | Once DeportivoOnce Deportiv |
| |
| 19 Mar 22 | r13 | Once DeportivoOnce Deportiv | 1 - 0 | Santa Tecla FCSanta Tecla F |
| |
| 25 Mar 22 | r14 | LimeñoLimeño | 0 - 0 | Once DeportivoOnce Deportiv |
| |
| 03 Apr 22 | r15 | Once DeportivoOnce Deportiv | 1 - 0 | Atlético MarteAtlético Mart |
| |
| 10 Apr 22 | r16 | Isidro MetapánIsidro Metapá | 2 - 2 | Once DeportivoOnce Deportiv |
| |
| 13 Apr 22 | r17 | Once DeportivoOnce Deportiv | 0 - 1 | ChalatenangoChalatenango |
| |
| 17 Apr 22 | r18 | FirpoFirpo | 0 - 0 | Once DeportivoOnce Deportiv |
| |
| 24 Apr 22 | r19  | Once DeportivoOnce Deportiv | 1 - 2 | Platense Puerto CortésPlatense Puer |
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| 29 Apr 22 | r09 | Alianza FCAlianza FC | 1 - 0 | Once DeportivoOnce Deportiv |
| |
| 01 May 22 | r21 | CD ÁguilaCD Águila | 0 - 1 | Once DeportivoOnce Deportiv |
| |
| 07 May 22 | r22 | Once DeportivoOnce Deportiv | 0 - 1 | JocoroJocoro |
Team 2021-2022 Schedules
Águila
Alianza FC
Cacahuatique
CD Hércules
FAS
Firpo
Fuerte San Francisco
Inter FA
Isidro Metapán
Municipal Limeño
Platense Zacatecoluca
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