| 01 Aug 21 | r01   | FASFAS | 3 - 1 | Santa Tecla FCSanta Tecla F |
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| 04 Aug 21 | r03 | FASFAS | 4 - 1 | JocoroJocoro |
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| 08 Aug 21 | r02 | CD ÁguilaCD Águila | 1 - 1 | FASFAS |
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| 15 Aug 21 | r04 | LimeñoLimeño | 0 - 3 | FASFAS |
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| 22 Aug 21 | r05 | FASFAS | 0 - 1 | Platense Puerto CortésPlatense Puer |
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| 26 Aug 21 | r06 | Alianza FCAlianza FC | 1 - 0 | FASFAS |
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| 29 Aug 21 | r07 | FASFAS | 3 - 1 | FirpoFirpo |
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| 12 Sep 21 | r08 | Once DeportivoOnce Deportiv | 1 - 3 | FASFAS |
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| 16 Sep 21 | r09 | ChalatenangoChalatenango | 1 - 2 | FASFAS |
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| 19 Sep 21 | r10 | FASFAS | 3 - 0 | Isidro MetapánIsidro Metapá |
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| 26 Sep 21 | r11 | Atlético MarteAtlético Mart | 0 - 1 | FASFAS |
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| 03 Oct 21 | r12 | Santa Tecla FCSanta Tecla F | 1 - 0 | FASFAS |
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| 17 Oct 21 | r13 | FASFAS | 0 - 1 | CD ÁguilaCD Águila |
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| 20 Oct 21 | r14 | JocoroJocoro | 0 - 0 | FASFAS |
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| 24 Oct 21 | r15 | FASFAS | 2 - 1 | LimeñoLimeño |
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| 30 Oct 21 | r16 | Platense Puerto CortésPlatense Puer | 0 - 0 | FASFAS |
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| 02 Nov 21 | r17 | FASFAS | 0 - 1 | Alianza FCAlianza FC |
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| 07 Nov 21 | r18 | FirpoFirpo | 2 - 0 | FASFAS |
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| 14 Nov 21 | r19 | FASFAS | 3 - 2 | Once DeportivoOnce Deportiv |
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| 17 Nov 21 | r20 | FASFAS | 1 - 1 | ChalatenangoChalatenango |
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| 21 Nov 21 | r21  | Isidro MetapánIsidro Metapá | 1 - 2 | FASFAS |
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| 27 Nov 21 | r22 | FASFAS | 2 - 2 | Atlético MarteAtlético Mart |
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| 03 Dec 21 | r00 | ChalatenangoChalatenango | 0 - 0 | FASFAS |
| 05 Dec 21 | r00 | FASFAS | 1 - 0 | ChalatenangoChalatenango |
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| 16 Jan 22 | r01 | Once DeportivoOnce Deportiv | 1 - 1 | FASFAS |
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| 23 Jan 22 | r02 | FASFAS | 0 - 3 | CD ÁguilaCD Águila |
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| 26 Jan 22 | r03 | JocoroJocoro | 2 - 2 | FASFAS |
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| 06 Feb 22 | r05 | FASFAS | 2 - 0 | Santa Tecla FCSanta Tecla F |
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| 09 Feb 22 | r06 | LimeñoLimeño | 1 - 1 | FASFAS |
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| 13 Feb 22 | r07 | FASFAS | 3 - 0 | Atlético MarteAtlético Mart |
| |
| 20 Feb 22 | r08 | Isidro MetapánIsidro Metapá | 1 - 1 | FASFAS |
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| 23 Feb 22 | r09 | FASFAS | 1 - 3 | ChalatenangoChalatenango |
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| 27 Feb 22 | r10 | FirpoFirpo | 2 - 3 | FASFAS |
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| 03 Mar 22 | r15 | Alianza FCAlianza FC | 1 - 1 | FASFAS |
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| 06 Mar 22 | r11 | FASFAS | 2 - 1 | Platense Puerto CortésPlatense Puer |
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| 13 Mar 22 | r12 | FASFAS | 0 - 0 | Once DeportivoOnce Deportiv |
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| 20 Mar 22 | r13 | CD ÁguilaCD Águila | 2 - 0 | FASFAS |
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| 23 Mar 22 | r14 | FASFAS | 2 - 1 | JocoroJocoro |
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| 03 Apr 22 | r04 | FASFAS | 1 - 3 | Alianza FCAlianza FC |
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| 10 Apr 22 | r16 | Santa Tecla FCSanta Tecla F | 1 - 1 | FASFAS |
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| 13 Apr 22 | r17 | FASFAS | 1 - 1 | LimeñoLimeño |
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| 17 Apr 22 | r18 | Atlético MarteAtlético Mart | 1 - 1 | FASFAS |
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| 24 Apr 22 | r19  | FASFAS | 4 - 1 | Isidro MetapánIsidro Metapá |
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| 28 Apr 22 | r20 | ChalatenangoChalatenango | 3 - 2 | FASFAS |
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| 01 May 22 | r21 | FASFAS | 0 - 1 | FirpoFirpo |
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| 07 May 22 | r22 | Platense Puerto CortésPlatense Puer | 1 - 2 | FASFAS |
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| 10 May 22 | r00 | FASFAS | 0 - 1 | Platense Puerto CortésPlatense Puer |
| 15 May 22 | r00 | Platense Puerto CortésPlatense Puer | 2 - 1 | FASFAS |
Team 2021-2022 Schedules
Águila
Alianza FC
Cacahuatique
CD Hércules
FAS
Firpo
Fuerte San Francisco
Inter FA
Isidro Metapán
Municipal Limeño
Platense Zacatecoluca
Zacatecoluca
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