| 15 Sep 21 | r09        | JocoroJocoro | 3 - 1 | LimeñoLimeño |
| 15 Sep 21 | r09        | Atlético MarteAtlético Mart | 1 - 3 | FirpoFirpo |
| 16 Sep 21 | r09        | Santa Tecla FCSanta Tecla F | 0 - 4 | Alianza FCAlianza FC |
| 16 Sep 21 | r09        | ChalatenangoChalatenango | 1 - 2 | FASFAS |
| 16 Sep 21 | r09        | CD ÁguilaCD Águila | 1 - 0 | Platense Puerto CortésPlatense Puer |
| 16 Sep 21 | r09        | Isidro MetapánIsidro Metapá | 0 - 1 | Once DeportivoOnce Deportiv |
| 23 Feb 22 | r09        | LimeñoLimeño | 2 - 0 | Atlético MarteAtlético Mart |
| 23 Feb 22 | r09        | FASFAS | 1 - 3 | ChalatenangoChalatenango |
| 23 Feb 22 | r09        | JocoroJocoro | 1 - 1 | FirpoFirpo |
| 24 Feb 22 | r09        | CD ÁguilaCD Águila | 2 - 2 | Platense Puerto CortésPlatense Puer |
| 24 Feb 22 | r09        | Santa Tecla FCSanta Tecla F | 1 - 0 | Isidro MetapánIsidro Metapá |
| 29 Apr 22 | r09        | Alianza FCAlianza FC | 1 - 0 | Once DeportivoOnce Deportiv |