| 11 Sep 21 | r08        | JocoroJocoro | 3 - 1 | ChalatenangoChalatenango |
| 12 Sep 21 | r08        | LimeñoLimeño | 1 - 0 | CD ÁguilaCD Águila |
| 12 Sep 21 | r08        | FirpoFirpo | 1 - 1 | Isidro MetapánIsidro Metapá |
| 12 Sep 21 | r08        | Once DeportivoOnce Deportiv | 1 - 3 | FASFAS |
| 12 Sep 21 | r08        | Platense Puerto CortésPlatense Puer | 1 - 0 | Santa Tecla FCSanta Tecla F |
| 12 Sep 21 | r08        | Alianza FCAlianza FC | 3 - 1 | Atlético MarteAtlético Mart |
| 19 Feb 22 | r08        | Atlético MarteAtlético Mart | 2 - 1 | Santa Tecla FCSanta Tecla F |
| 20 Feb 22 | r08        | Isidro MetapánIsidro Metapá | 1 - 1 | FASFAS |
| 20 Feb 22 | r08        | ChalatenangoChalatenango | 1 - 0 | JocoroJocoro |
| 20 Feb 22 | r08        | FirpoFirpo | 0 - 0 | CD ÁguilaCD Águila |
| 20 Feb 22 | r08        | LimeñoLimeño | 0 - 0 | Alianza FCAlianza FC |
| 20 Feb 22 | r08        | Platense Puerto CortésPlatense Puer | 1 - 0 | Once DeportivoOnce Deportiv |