| 29 Aug 21 | r07        | ChalatenangoChalatenango | 1 - 2 | Once DeportivoOnce Deportiv |
| 29 Aug 21 | r07        | CD ÁguilaCD Águila | 2 - 2 | JocoroJocoro |
| 29 Aug 21 | r07        | Santa Tecla FCSanta Tecla F | 1 - 1 | LimeñoLimeño |
| 29 Aug 21 | r07        | Isidro MetapánIsidro Metapá | 1 - 2 | Alianza FCAlianza FC |
| 29 Aug 21 | r07        | FASFAS | 3 - 1 | FirpoFirpo |
| 07 Nov 21 | r07        | Atlético MarteAtlético Mart | 0 - 0 | Platense Puerto CortésPlatense Puer |
| 12 Feb 22 | r07        | JocoroJocoro | 2 - 1 | Isidro MetapánIsidro Metapá |
| 13 Feb 22 | r07        | CD ÁguilaCD Águila | 0 - 1 | ChalatenangoChalatenango |
| 13 Feb 22 | r07        | Santa Tecla FCSanta Tecla F | 1 - 1 | LimeñoLimeño |
| 13 Feb 22 | r07        | Once DeportivoOnce Deportiv | 1 - 0 | FirpoFirpo |
| 13 Feb 22 | r07        | FASFAS | 3 - 0 | Atlético MarteAtlético Mart |
| 13 Feb 22 | r07        | Alianza FCAlianza FC | 1 - 0 | Platense Puerto CortésPlatense Puer |