| 25 Aug 21 | r06        | JocoroJocoro | 2 - 0 | Santa Tecla FCSanta Tecla F |
| 25 Aug 21 | r06        | LimeñoLimeño | 1 - 2 | Atlético MarteAtlético Mart |
| 25 Aug 21 | r06        | Platense Puerto CortésPlatense Puer | 2 - 1 | Isidro MetapánIsidro Metapá |
| 25 Aug 21 | r06        | FirpoFirpo | 2 - 2 | Once DeportivoOnce Deportiv |
| 26 Aug 21 | r06        | CD ÁguilaCD Águila | 2 - 1 | ChalatenangoChalatenango |
| 26 Aug 21 | r06        | Alianza FCAlianza FC | 1 - 0 | FASFAS |
| 09 Feb 22 | r06        | LimeñoLimeño | 1 - 1 | FASFAS |
| 09 Feb 22 | r06        | Atlético MarteAtlético Mart | 0 - 0 | JocoroJocoro |
| 10 Feb 22 | r06        | Isidro MetapánIsidro Metapá | 2 - 2 | CD ÁguilaCD Águila |
| 10 Feb 22 | r06        | ChalatenangoChalatenango | 1 - 0 | Once DeportivoOnce Deportiv |
| 10 Feb 22 | r06        | FirpoFirpo | 1 - 1 | Platense Puerto CortésPlatense Puer |
| 10 Feb 22 | r06        | Santa Tecla FCSanta Tecla F | 2 - 3 | Alianza FCAlianza FC |