| 21 Aug 21 | r05        | ChalatenangoChalatenango | 0 - 2 | FirpoFirpo |
| 22 Aug 21 | r05        | Santa Tecla FCSanta Tecla F | 2 - 3 | CD ÁguilaCD Águila |
| 22 Aug 21 | r05        | Isidro MetapánIsidro Metapá | 1 - 0 | LimeñoLimeño |
| 22 Aug 21 | r05        | Atlético MarteAtlético Mart | 2 - 1 | JocoroJocoro |
| 22 Aug 21 | r05        | FASFAS | 0 - 1 | Platense Puerto CortésPlatense Puer |
| 30 Oct 21 | r05        | Once DeportivoOnce Deportiv | 2 - 3 | Alianza FCAlianza FC |
| 04 Feb 22 | r05        | JocoroJocoro | 3 - 0 | LimeñoLimeño |
| 06 Feb 22 | r05        | CD ÁguilaCD Águila | 2 - 1 | Atlético MarteAtlético Mart |
| 06 Feb 22 | r05        | Once DeportivoOnce Deportiv | 0 - 0 | Isidro MetapánIsidro Metapá |
| 06 Feb 22 | r05        | FASFAS | 2 - 0 | Santa Tecla FCSanta Tecla F |
| 06 Feb 22 | r05        | Platense Puerto CortésPlatense Puer | 1 - 1 | ChalatenangoChalatenango |
| 06 Feb 22 | r05        | Alianza FCAlianza FC | 0 - 0 | FirpoFirpo |