| 14 Aug 21 | r04        | JocoroJocoro | 1 - 0 | Isidro MetapánIsidro Metapá |
| 15 Aug 21 | r04        | Santa Tecla FCSanta Tecla F | 1 - 1 | ChalatenangoChalatenango |
| 15 Aug 21 | r04        | LimeñoLimeño | 0 - 3 | FASFAS |
| 15 Aug 21 | r04        | CD ÁguilaCD Águila | 4 - 1 | Atlético MarteAtlético Mart |
| 15 Aug 21 | r04        | Platense Puerto CortésPlatense Puer | 1 - 1 | Once DeportivoOnce Deportiv |
| 15 Aug 21 | r04        | Alianza FCAlianza FC | 2 - 2 | FirpoFirpo |
| 29 Jan 22 | r04        | Atlético MarteAtlético Mart | 1 - 1 | Once DeportivoOnce Deportiv |
| 30 Jan 22 | r04        | Isidro MetapánIsidro Metapá | 1 - 1 | Platense Puerto CortésPlatense Puer |
| 30 Jan 22 | r04        | ChalatenangoChalatenango | 2 - 1 | FirpoFirpo |
| 30 Jan 22 | r04        | Santa Tecla FCSanta Tecla F | 3 - 0 | JocoroJocoro |
| 30 Jan 22 | r04        | LimeñoLimeño | 0 - 3 | CD ÁguilaCD Águila |
| 03 Apr 22 | r04        | FASFAS | 1 - 3 | Alianza FCAlianza FC |