| 27 Nov 21 | r22        | Platense Puerto CortésPlatense Puer | 0 - 1 | LimeñoLimeño |
| 27 Nov 21 | r22        | Alianza FCAlianza FC | 2 - 0 | JocoroJocoro |
| 27 Nov 21 | r22        | FirpoFirpo | 1 - 0 | CD ÁguilaCD Águila |
| 27 Nov 21 | r22        | Once DeportivoOnce Deportiv | 4 - 3 | Santa Tecla FCSanta Tecla F |
| 27 Nov 21 | r22        | FASFAS | 2 - 2 | Atlético MarteAtlético Mart |
| 27 Nov 21 | r22        | ChalatenangoChalatenango | 1 - 0 | Isidro MetapánIsidro Metapá |
| 06 Mar 22 | r22        | Alianza FCAlianza FC | 0 - 0 | CD ÁguilaCD Águila |
| 07 May 22 | r22        | Isidro MetapánIsidro Metapá | 1 - 1 | Atlético MarteAtlético Mart |
| 07 May 22 | r22        | ChalatenangoChalatenango | 0 - 0 | LimeñoLimeño |
| 07 May 22 | r22        | FirpoFirpo | 2 - 0 | Santa Tecla FCSanta Tecla F |
| 07 May 22 | r22        | Platense Puerto CortésPlatense Puer | 1 - 2 | FASFAS |
| 07 May 22 | r22        | Once DeportivoOnce Deportiv | 0 - 1 | JocoroJocoro |