| 07 Aug 21 | r02        | Atlético MarteAtlético Mart | 0 - 2 | ChalatenangoChalatenango |
| 08 Aug 21 | r02        | LimeñoLimeño | 1 - 1 | FirpoFirpo |
| 08 Aug 21 | r02        | Santa Tecla FCSanta Tecla F | 3 - 0 | Isidro MetapánIsidro Metapá |
| 08 Aug 21 | r02        | CD ÁguilaCD Águila | 1 - 1 | FASFAS |
| 08 Aug 21 | r02        | JocoroJocoro | 3 - 4 | Once DeportivoOnce Deportiv |
| 08 Aug 21 | r02        | Platense Puerto CortésPlatense Puer | 2 - 2 | Alianza FCAlianza FC |
| 22 Jan 22 | r02        | JocoroJocoro | 3 - 2 | Alianza FCAlianza FC |
| 23 Jan 22 | r02        | Santa Tecla FCSanta Tecla F | 1 - 1 | Once DeportivoOnce Deportiv |
| 23 Jan 22 | r02        | Isidro MetapánIsidro Metapá | 2 - 1 | ChalatenangoChalatenango |
| 23 Jan 22 | r02        | Atlético MarteAtlético Mart | 2 - 1 | FirpoFirpo |
| 23 Jan 22 | r02        | FASFAS | 0 - 3 | CD ÁguilaCD Águila |
| 23 Jan 22 | r02        | LimeñoLimeño | 2 - 1 | Platense Puerto CortésPlatense Puer |