| 29 Aug 21 | r18        | Platense Puerto CortésPlatense Puer | 0 - 2 | Atlético MarteAtlético Mart |
| 06 Nov 21 | r18        | JocoroJocoro | 2 - 2 | CD ÁguilaCD Águila |
| 07 Nov 21 | r18        | FirpoFirpo | 2 - 0 | FASFAS |
| 07 Nov 21 | r18        | Alianza FCAlianza FC | 1 - 0 | Isidro MetapánIsidro Metapá |
| 07 Nov 21 | r18        | LimeñoLimeño | 1 - 1 | Santa Tecla FCSanta Tecla F |
| 07 Nov 21 | r18        | Once DeportivoOnce Deportiv | 1 - 2 | ChalatenangoChalatenango |
| 17 Apr 22 | r18        | Isidro MetapánIsidro Metapá | 3 - 0 | JocoroJocoro |
| 17 Apr 22 | r18        | ChalatenangoChalatenango | 0 - 0 | CD ÁguilaCD Águila |
| 17 Apr 22 | r18        | LimeñoLimeño | 2 - 0 | Santa Tecla FCSanta Tecla F |
| 17 Apr 22 | r18        | Atlético MarteAtlético Mart | 1 - 1 | FASFAS |
| 17 Apr 22 | r18        | FirpoFirpo | 0 - 0 | Once DeportivoOnce Deportiv |
| 17 Apr 22 | r18        | Platense Puerto CortésPlatense Puer | 0 - 1 | Alianza FCAlianza FC |