| 24 Oct 21 | r15        | ChalatenangoChalatenango | 0 - 2 | Santa Tecla FCSanta Tecla F |
| 24 Oct 21 | r15        | Isidro MetapánIsidro Metapá | 1 - 1 | JocoroJocoro |
| 24 Oct 21 | r15        | Atlético MarteAtlético Mart | 1 - 2 | CD ÁguilaCD Águila |
| 24 Oct 21 | r15        | Once DeportivoOnce Deportiv | 1 - 1 | Platense Puerto CortésPlatense Puer |
| 24 Oct 21 | r15        | FirpoFirpo | 2 - 1 | Alianza FCAlianza FC |
| 24 Oct 21 | r15        | FASFAS | 2 - 1 | LimeñoLimeño |
| 03 Mar 22 | r15        | Alianza FCAlianza FC | 1 - 1 | FASFAS |
| 02 Apr 22 | r15        | JocoroJocoro | 1 - 0 | Santa Tecla FCSanta Tecla F |
| 03 Apr 22 | r15        | CD ÁguilaCD Águila | 1 - 0 | LimeñoLimeño |
| 03 Apr 22 | r15        | Once DeportivoOnce Deportiv | 1 - 0 | Atlético MarteAtlético Mart |
| 03 Apr 22 | r15        | FirpoFirpo | 1 - 2 | ChalatenangoChalatenango |
| 03 Apr 22 | r15        | Platense Puerto CortésPlatense Puer | 2 - 1 | Isidro MetapánIsidro Metapá |