| 09 Oct 21 | r14        | LimeñoLimeño | 1 - 1 | Once DeportivoOnce Deportiv |
| 09 Oct 21 | r14        | Platense Puerto CortésPlatense Puer | 1 - 3 | FirpoFirpo |
| 20 Oct 21 | r14        | JocoroJocoro | 0 - 0 | FASFAS |
| 21 Oct 21 | r14        | Santa Tecla FCSanta Tecla F | 0 - 0 | Atlético MarteAtlético Mart |
| 21 Oct 21 | r14        | CD ÁguilaCD Águila | 4 - 0 | Isidro MetapánIsidro Metapá |
| 21 Oct 21 | r14        | Alianza FCAlianza FC | 1 - 0 | ChalatenangoChalatenango |
| 23 Mar 22 | r14        | Atlético MarteAtlético Mart | 0 - 1 | Platense Puerto CortésPlatense Puer |
| 23 Mar 22 | r14        | FASFAS | 2 - 1 | JocoroJocoro |
| 24 Mar 22 | r14        | Isidro MetapánIsidro Metapá | 1 - 1 | FirpoFirpo |
| 24 Mar 22 | r14        | Santa Tecla FCSanta Tecla F | 2 - 2 | CD ÁguilaCD Águila |
| 25 Mar 22 | r14        | ChalatenangoChalatenango | 2 - 0 | Alianza FCAlianza FC |
| 25 Mar 22 | r14        | LimeñoLimeño | 0 - 0 | Once DeportivoOnce Deportiv |