| 02 Oct 21 | r12        | JocoroJocoro | 2 - 1 | FirpoFirpo |
| 02 Oct 21 | r12        | Atlético MarteAtlético Mart | 2 - 0 | Isidro MetapánIsidro Metapá |
| 02 Oct 21 | r12        | Platense Puerto CortésPlatense Puer | 2 - 1 | ChalatenangoChalatenango |
| 02 Oct 21 | r12        | LimeñoLimeño | 0 - 3 | Alianza FCAlianza FC |
| 03 Oct 21 | r12        | Santa Tecla FCSanta Tecla F | 1 - 0 | FASFAS |
| 03 Oct 21 | r12        | CD ÁguilaCD Águila | 1 - 2 | Once DeportivoOnce Deportiv |
| 12 Mar 22 | r12        | Atlético MarteAtlético Mart | 4 - 2 | ChalatenangoChalatenango |
| 12 Mar 22 | r12        | JocoroJocoro | 0 - 2 | CD ÁguilaCD Águila |
| 13 Mar 22 | r12        | Santa Tecla FCSanta Tecla F | 0 - 1 | Platense Puerto CortésPlatense Puer |
| 13 Mar 22 | r12        | Isidro MetapánIsidro Metapá | 0 - 0 | Alianza FCAlianza FC |
| 13 Mar 22 | r12        | LimeñoLimeño | 3 - 2 | FirpoFirpo |
| 13 Mar 22 | r12        | FASFAS | 0 - 0 | Once DeportivoOnce Deportiv |