| 25 Sep 21 | r11        | JocoroJocoro | 3 - 3 | Alianza FCAlianza FC |
| 26 Sep 21 | r11        | CD ÁguilaCD Águila | 1 - 1 | FirpoFirpo |
| 26 Sep 21 | r11        | Santa Tecla FCSanta Tecla F | 0 - 1 | Once DeportivoOnce Deportiv |
| 26 Sep 21 | r11        | Isidro MetapánIsidro Metapá | 1 - 4 | ChalatenangoChalatenango |
| 26 Sep 21 | r11        | Atlético MarteAtlético Mart | 0 - 1 | FASFAS |
| 27 Sep 21 | r11        | LimeñoLimeño | 0 - 1 | Platense Puerto CortésPlatense Puer |
| 05 Mar 22 | r11        | Atlético MarteAtlético Mart | 0 - 1 | Isidro MetapánIsidro Metapá |
| 05 Mar 22 | r11        | JocoroJocoro | 2 - 1 | Once DeportivoOnce Deportiv |
| 06 Mar 22 | r11        | Santa Tecla FCSanta Tecla F | 1 - 5 | FirpoFirpo |
| 06 Mar 22 | r11        | LimeñoLimeño | 0 - 1 | ChalatenangoChalatenango |
| 06 Mar 22 | r11        | FASFAS | 2 - 1 | Platense Puerto CortésPlatense Puer |
| 07 May 22 | r11        | CD ÁguilaCD Águila | 3 - 1 | Alianza FCAlianza FC |