| 19 Sep 21 | r10        | ChalatenangoChalatenango | 1 - 1 | LimeñoLimeño |
| 19 Sep 21 | r10        | Alianza FCAlianza FC | 2 - 1 | CD ÁguilaCD Águila |
| 19 Sep 21 | r10        | FirpoFirpo | 0 - 2 | Santa Tecla FCSanta Tecla F |
| 19 Sep 21 | r10        | Once DeportivoOnce Deportiv | 0 - 0 | Atlético MarteAtlético Mart |
| 19 Sep 21 | r10        | Platense Puerto CortésPlatense Puer | 1 - 1 | JocoroJocoro |
| 19 Sep 21 | r10        | FASFAS | 3 - 0 | Isidro MetapánIsidro Metapá |
| 27 Feb 22 | r10        | Isidro MetapánIsidro Metapá | 2 - 0 | LimeñoLimeño |
| 27 Feb 22 | r10        | ChalatenangoChalatenango | 1 - 0 | Santa Tecla FCSanta Tecla F |
| 27 Feb 22 | r10        | FirpoFirpo | 2 - 3 | FASFAS |
| 27 Feb 22 | r10        | Once DeportivoOnce Deportiv | 1 - 4 | CD ÁguilaCD Águila |
| 27 Feb 22 | r10        | Alianza FCAlianza FC | 3 - 2 | Atlético MarteAtlético Mart |
| 27 Feb 22 | r10        | Platense Puerto CortésPlatense Puer | 2 - 0 | JocoroJocoro |