| 01 Aug 21 | r01        | ChalatenangoChalatenango | 2 - 2 | Platense Puerto CortésPlatense Puer |
| 01 Aug 21 | r01        | Isidro MetapánIsidro Metapá | 0 - 0 | Atlético MarteAtlético Mart |
| 01 Aug 21 | r01        | Once DeportivoOnce Deportiv | 2 - 2 | CD ÁguilaCD Águila |
| 01 Aug 21 | r01        | FirpoFirpo | 1 - 1 | JocoroJocoro |
| 01 Aug 21 | r01        | FASFAS | 3 - 1 | Santa Tecla FCSanta Tecla F |
| 01 Aug 21 | r01        | Alianza FCAlianza FC | 4 - 1 | LimeñoLimeño |
| 16 Jan 22 | r01        | CD ÁguilaCD Águila | 0 - 0 | JocoroJocoro |
| 16 Jan 22 | r01        | ChalatenangoChalatenango | 0 - 0 | Atlético MarteAtlético Mart |
| 16 Jan 22 | r01        | Once DeportivoOnce Deportiv | 1 - 1 | FASFAS |
| 16 Jan 22 | r01        | FirpoFirpo | 1 - 0 | LimeñoLimeño |
| 16 Jan 22 | r01        | Alianza FCAlianza FC | 0 - 2 | Isidro MetapánIsidro Metapá |
| 16 Jan 22 | r01        | Platense Puerto CortésPlatense Puer | 0 - 1 | Santa Tecla FCSanta Tecla F |