| 04 Aug 21 | r03        | FASFAS | 4 - 1 | JocoroJocoro |
| 10 Aug 21 | r03        | Atlético MarteAtlético Mart | 0 - 1 | Santa Tecla FCSanta Tecla F |
| 11 Aug 21 | r03        | ChalatenangoChalatenango | 2 - 1 | Alianza FCAlianza FC |
| 11 Aug 21 | r03        | Once DeportivoOnce Deportiv | 4 - 1 | LimeñoLimeño |
| 11 Aug 21 | r03        | FirpoFirpo | 3 - 2 | Platense Puerto CortésPlatense Puer |
| 12 Aug 21 | r03        | Isidro MetapánIsidro Metapá | 2 - 2 | CD ÁguilaCD Águila |
| 26 Jan 22 | r03        | JocoroJocoro | 2 - 2 | FASFAS |
| 26 Jan 22 | r03        | Platense Puerto CortésPlatense Puer | 1 - 1 | Atlético MarteAtlético Mart |
| 26 Jan 22 | r03        | Once DeportivoOnce Deportiv | 3 - 2 | LimeñoLimeño |
| 27 Jan 22 | r03        | CD ÁguilaCD Águila | 4 - 1 | Santa Tecla FCSanta Tecla F |
| 27 Jan 22 | r03        | FirpoFirpo | 0 - 0 | Isidro MetapánIsidro Metapá |
| 27 Jan 22 | r03        | Alianza FCAlianza FC | 3 - 1 | ChalatenangoChalatenango |