| 01 Dec 21 | r00   | JocoroJocoro | 2 - 3 | Alianza FCAlianza FC |
| 01 Dec 21 | r00 | Platense Puerto CortésPlatense Puer | 2 - 2 | FirpoFirpo |
| 02 Dec 21 | r00 | CD ÁguilaCD Águila | 1 - 1 | Once DeportivoOnce Deportiv |
| 03 Dec 21 | r00 | ChalatenangoChalatenango | 0 - 0 | FASFAS |
| 05 Dec 21 | r00 | Alianza FCAlianza FC | 1 - 0 | JocoroJocoro |
| 05 Dec 21 | r00 | Once DeportivoOnce Deportiv | 0 - 0 | CD ÁguilaCD Águila |
| 05 Dec 21 | r00 | FASFAS | 1 - 0 | ChalatenangoChalatenango |
| 05 Dec 21 | r00 | FirpoFirpo | 1 - 2 | Platense Puerto CortésPlatense Puer |
| 08 Dec 21 | r00 | Once DeportivoOnce Deportiv | 1 - 1 | Alianza FCAlianza FC |
| 10 Dec 21 | r00 | ChalatenangoChalatenango | 1 - 1 | Platense Puerto CortésPlatense Puer |
| 12 Dec 21 | r00 | Alianza FCAlianza FC | 2 - 0 | Once DeportivoOnce Deportiv |
| 12 Dec 21 | r00 | Platense Puerto CortésPlatense Puer | 1 - 0 | ChalatenangoChalatenango |
| 19 Dec 21 | r00 | Alianza FCAlianza FC | 2 - 1 | Platense Puerto CortésPlatense Puer |
| 10 May 22 | r00 | FASFAS | 0 - 1 | Platense Puerto CortésPlatense Puer |
| 10 May 22 | r00  | JocoroJocoro | 1 - 2 | CD ÁguilaCD Águila |
| 12 May 22 | r00 | FirpoFirpo | 1 - 2 | Alianza FCAlianza FC |
| 12 May 22 | r00 | Isidro MetapánIsidro Metapá | 1 - 0 | ChalatenangoChalatenango |
| 15 May 22 | r00 | CD ÁguilaCD Águila | 1 - 1 | JocoroJocoro |
| 15 May 22 | r00 | ChalatenangoChalatenango | 1 - 2 | Isidro MetapánIsidro Metapá |
| 15 May 22 | r00 | Platense Puerto CortésPlatense Puer | 2 - 1 | FASFAS |
| 15 May 22 | r00 | Alianza FCAlianza FC | 2 - 1 | FirpoFirpo |
| 18 May 22 | r00 | Platense Puerto CortésPlatense Puer | 1 - 0 | Alianza FCAlianza FC |
| 19 May 22 | r00 | Isidro MetapánIsidro Metapá | 1 - 2 | CD ÁguilaCD Águila |
| 22 May 22 | r00 | CD ÁguilaCD Águila | 2 - 1 | Isidro MetapánIsidro Metapá |
| 22 May 22 | r00 | Alianza FCAlianza FC | 3 - 1 | Platense Puerto CortésPlatense Puer |
| 29 May 22 | r00 | Alianza FCAlianza FC | 1 - 1 | CD ÁguilaCD Águila |
| 29 May 22 | r00 | CD ÁguilaCD Águila | 1 - 1 | Alianza FCAlianza FC |
Team 2021-2022 Schedules
Águila
Alianza FC
Cacahuatique
CD Hércules
FAS
Firpo
Fuerte San Francisco
Inter FA
Isidro Metapán
Municipal Limeño
Platense Zacatecoluca
Zacatecoluca
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