| 01 Aug 21 | r01   | ChalatenangoChalatenango | 2 - 2 | Platense Puerto CortésPlatense Puer |
| 01 Aug 21 | r01 | Isidro MetapánIsidro Metapá | 0 - 0 | Atlético MarteAtlético Mart |
| 01 Aug 21 | r01 | Once DeportivoOnce Deportiv | 2 - 2 | CD ÁguilaCD Águila |
| 01 Aug 21 | r01 | FirpoFirpo | 1 - 1 | JocoroJocoro |
| 01 Aug 21 | r01 | FASFAS | 3 - 1 | Santa Tecla FCSanta Tecla F |
| 01 Aug 21 | r01 | Alianza FCAlianza FC | 4 - 1 | LimeñoLimeño |
| |
| 04 Aug 21 | r03 | FASFAS | 4 - 1 | JocoroJocoro |
| |
| 07 Aug 21 | r02 | Atlético MarteAtlético Mart | 0 - 2 | ChalatenangoChalatenango |
| 08 Aug 21 | r02 | LimeñoLimeño | 1 - 1 | FirpoFirpo |
| 08 Aug 21 | r02 | Santa Tecla FCSanta Tecla F | 3 - 0 | Isidro MetapánIsidro Metapá |
| 08 Aug 21 | r02 | CD ÁguilaCD Águila | 1 - 1 | FASFAS |
| 08 Aug 21 | r02 | JocoroJocoro | 3 - 4 | Once DeportivoOnce Deportiv |
| 08 Aug 21 | r02 | Platense Puerto CortésPlatense Puer | 2 - 2 | Alianza FCAlianza FC |
| |
| 10 Aug 21 | r03 | Atlético MarteAtlético Mart | 0 - 1 | Santa Tecla FCSanta Tecla F |
| 11 Aug 21 | r03 | ChalatenangoChalatenango | 2 - 1 | Alianza FCAlianza FC |
| 11 Aug 21 | r03 | Once DeportivoOnce Deportiv | 4 - 1 | LimeñoLimeño |
| 11 Aug 21 | r03 | FirpoFirpo | 3 - 2 | Platense Puerto CortésPlatense Puer |
| 12 Aug 21 | r03 | Isidro MetapánIsidro Metapá | 2 - 2 | CD ÁguilaCD Águila |
| |
| 14 Aug 21 | r04 | JocoroJocoro | 1 - 0 | Isidro MetapánIsidro Metapá |
| 15 Aug 21 | r04 | Santa Tecla FCSanta Tecla F | 1 - 1 | ChalatenangoChalatenango |
| 15 Aug 21 | r04 | LimeñoLimeño | 0 - 3 | FASFAS |
| 15 Aug 21 | r04 | CD ÁguilaCD Águila | 4 - 1 | Atlético MarteAtlético Mart |
| 15 Aug 21 | r04 | Platense Puerto CortésPlatense Puer | 1 - 1 | Once DeportivoOnce Deportiv |
| 15 Aug 21 | r04 | Alianza FCAlianza FC | 2 - 2 | FirpoFirpo |
| |
| 21 Aug 21 | r05 | ChalatenangoChalatenango | 0 - 2 | FirpoFirpo |
| 22 Aug 21 | r05 | Santa Tecla FCSanta Tecla F | 2 - 3 | CD ÁguilaCD Águila |
| 22 Aug 21 | r05 | Isidro MetapánIsidro Metapá | 1 - 0 | LimeñoLimeño |
| 22 Aug 21 | r05 | Atlético MarteAtlético Mart | 2 - 1 | JocoroJocoro |
| 22 Aug 21 | r05 | FASFAS | 0 - 1 | Platense Puerto CortésPlatense Puer |
| |
| 25 Aug 21 | r06 | JocoroJocoro | 2 - 0 | Santa Tecla FCSanta Tecla F |
| 25 Aug 21 | r06 | LimeñoLimeño | 1 - 2 | Atlético MarteAtlético Mart |
| 25 Aug 21 | r06 | Platense Puerto CortésPlatense Puer | 2 - 1 | Isidro MetapánIsidro Metapá |
| 25 Aug 21 | r06 | FirpoFirpo | 2 - 2 | Once DeportivoOnce Deportiv |
| 26 Aug 21 | r06 | CD ÁguilaCD Águila | 2 - 1 | ChalatenangoChalatenango |
| 26 Aug 21 | r06 | Alianza FCAlianza FC | 1 - 0 | FASFAS |
| |
| 29 Aug 21 | r07 | ChalatenangoChalatenango | 1 - 2 | Once DeportivoOnce Deportiv |
| 29 Aug 21 | r07 | CD ÁguilaCD Águila | 2 - 2 | JocoroJocoro |
| 29 Aug 21 | r07 | Santa Tecla FCSanta Tecla F | 1 - 1 | LimeñoLimeño |
| 29 Aug 21 | r07 | Isidro MetapánIsidro Metapá | 1 - 2 | Alianza FCAlianza FC |
| 29 Aug 21 | r07 | FASFAS | 3 - 1 | FirpoFirpo |
| |
| 29 Aug 21 | r18 | Platense Puerto CortésPlatense Puer | 0 - 2 | Atlético MarteAtlético Mart |
| |
| 10 Sep 21 | r16 | Alianza FCAlianza FC | 1 - 0 | Once DeportivoOnce Deportiv |
| |
| 11 Sep 21 | r08 | JocoroJocoro | 3 - 1 | ChalatenangoChalatenango |
| 12 Sep 21 | r08 | LimeñoLimeño | 1 - 0 | CD ÁguilaCD Águila |
| 12 Sep 21 | r08 | FirpoFirpo | 1 - 1 | Isidro MetapánIsidro Metapá |
| 12 Sep 21 | r08 | Once DeportivoOnce Deportiv | 1 - 3 | FASFAS |
| 12 Sep 21 | r08 | Platense Puerto CortésPlatense Puer | 1 - 0 | Santa Tecla FCSanta Tecla F |
| 12 Sep 21 | r08 | Alianza FCAlianza FC | 3 - 1 | Atlético MarteAtlético Mart |
| |
| 15 Sep 21 | r09 | JocoroJocoro | 3 - 1 | LimeñoLimeño |
| 15 Sep 21 | r09 | Atlético MarteAtlético Mart | 1 - 3 | FirpoFirpo |
| 16 Sep 21 | r09 | Santa Tecla FCSanta Tecla F | 0 - 4 | Alianza FCAlianza FC |
| 16 Sep 21 | r09 | ChalatenangoChalatenango | 1 - 2 | FASFAS |
| 16 Sep 21 | r09 | CD ÁguilaCD Águila | 1 - 0 | Platense Puerto CortésPlatense Puer |
| 16 Sep 21 | r09 | Isidro MetapánIsidro Metapá | 0 - 1 | Once DeportivoOnce Deportiv |
| |
| 19 Sep 21 | r10 | ChalatenangoChalatenango | 1 - 1 | LimeñoLimeño |
| 19 Sep 21 | r10 | Alianza FCAlianza FC | 2 - 1 | CD ÁguilaCD Águila |
| 19 Sep 21 | r10 | FirpoFirpo | 0 - 2 | Santa Tecla FCSanta Tecla F |
| 19 Sep 21 | r10 | Once DeportivoOnce Deportiv | 0 - 0 | Atlético MarteAtlético Mart |
| 19 Sep 21 | r10 | Platense Puerto CortésPlatense Puer | 1 - 1 | JocoroJocoro |
| 19 Sep 21 | r10 | FASFAS | 3 - 0 | Isidro MetapánIsidro Metapá |
| |
| 25 Sep 21 | r11 | JocoroJocoro | 3 - 3 | Alianza FCAlianza FC |
| 26 Sep 21 | r11 | CD ÁguilaCD Águila | 1 - 1 | FirpoFirpo |
| 26 Sep 21 | r11 | Santa Tecla FCSanta Tecla F | 0 - 1 | Once DeportivoOnce Deportiv |
| 26 Sep 21 | r11 | Isidro MetapánIsidro Metapá | 1 - 4 | ChalatenangoChalatenango |
| 26 Sep 21 | r11 | Atlético MarteAtlético Mart | 0 - 1 | FASFAS |
| 27 Sep 21 | r11 | LimeñoLimeño | 0 - 1 | Platense Puerto CortésPlatense Puer |
| |
| 02 Oct 21 | r12 | JocoroJocoro | 2 - 1 | FirpoFirpo |
| 02 Oct 21 | r12 | Atlético MarteAtlético Mart | 2 - 0 | Isidro MetapánIsidro Metapá |
| 02 Oct 21 | r12 | Platense Puerto CortésPlatense Puer | 2 - 1 | ChalatenangoChalatenango |
| 02 Oct 21 | r12 | LimeñoLimeño | 0 - 3 | Alianza FCAlianza FC |
| 03 Oct 21 | r12 | Santa Tecla FCSanta Tecla F | 1 - 0 | FASFAS |
| 03 Oct 21 | r12 | CD ÁguilaCD Águila | 1 - 2 | Once DeportivoOnce Deportiv |
| |
| 09 Oct 21 | r14 | LimeñoLimeño | 1 - 1 | Once DeportivoOnce Deportiv |
| 09 Oct 21 | r14 | Platense Puerto CortésPlatense Puer | 1 - 3 | FirpoFirpo |
| |
| 17 Oct 21 | r13 | ChalatenangoChalatenango | 2 - 2 | Atlético MarteAtlético Mart |
| 17 Oct 21 | r13 | FirpoFirpo | 1 - 1 | LimeñoLimeño |
| 17 Oct 21 | r13 | Isidro MetapánIsidro Metapá | 1 - 1 | Santa Tecla FCSanta Tecla F |
| 17 Oct 21 | r13 | Once DeportivoOnce Deportiv | 2 - 2 | JocoroJocoro |
| 17 Oct 21 | r13 | FASFAS | 0 - 1 | CD ÁguilaCD Águila |
| 17 Oct 21 | r13 | Alianza FCAlianza FC | 4 - 0 | Platense Puerto CortésPlatense Puer |
| |
| 20 Oct 21 | r14 | JocoroJocoro | 0 - 0 | FASFAS |
| 21 Oct 21 | r14 | Santa Tecla FCSanta Tecla F | 0 - 0 | Atlético MarteAtlético Mart |
| 21 Oct 21 | r14 | CD ÁguilaCD Águila | 4 - 0 | Isidro MetapánIsidro Metapá |
| 21 Oct 21 | r14 | Alianza FCAlianza FC | 1 - 0 | ChalatenangoChalatenango |
| |
| 24 Oct 21 | r15 | ChalatenangoChalatenango | 0 - 2 | Santa Tecla FCSanta Tecla F |
| 24 Oct 21 | r15 | Isidro MetapánIsidro Metapá | 1 - 1 | JocoroJocoro |
| 24 Oct 21 | r15 | Atlético MarteAtlético Mart | 1 - 2 | CD ÁguilaCD Águila |
| 24 Oct 21 | r15 | Once DeportivoOnce Deportiv | 1 - 1 | Platense Puerto CortésPlatense Puer |
| 24 Oct 21 | r15 | FirpoFirpo | 2 - 1 | Alianza FCAlianza FC |
| 24 Oct 21 | r15 | FASFAS | 2 - 1 | LimeñoLimeño |
| |
| 30 Oct 21 | r16 | JocoroJocoro | 1 - 1 | Atlético MarteAtlético Mart |
| 30 Oct 21 | r16 | LimeñoLimeño | 2 - 2 | Isidro MetapánIsidro Metapá |
| |
| 30 Oct 21 | r05 | Once DeportivoOnce Deportiv | 2 - 3 | Alianza FCAlianza FC |
| |
| 30 Oct 21 | r16 | Platense Puerto CortésPlatense Puer | 0 - 0 | FASFAS |
| 31 Oct 21 | r16 | CD ÁguilaCD Águila | 2 - 0 | Santa Tecla FCSanta Tecla F |
| 31 Oct 21 | r16 | FirpoFirpo | 4 - 2 | ChalatenangoChalatenango |
| |
| 02 Nov 21 | r17 | Atlético MarteAtlético Mart | 2 - 0 | LimeñoLimeño |
| 02 Nov 21 | r17 | FASFAS | 0 - 1 | Alianza FCAlianza FC |
| 02 Nov 21 | r17 | Once DeportivoOnce Deportiv | 1 - 0 | FirpoFirpo |
| 03 Nov 21 | r17 | ChalatenangoChalatenango | 1 - 1 | CD ÁguilaCD Águila |
| 03 Nov 21 | r17 | Santa Tecla FCSanta Tecla F | 2 - 1 | JocoroJocoro |
| 03 Nov 21 | r17 | Isidro MetapánIsidro Metapá | 1 - 0 | Platense Puerto CortésPlatense Puer |
| |
| 06 Nov 21 | r18 | JocoroJocoro | 2 - 2 | CD ÁguilaCD Águila |
| 07 Nov 21 | r18 | FirpoFirpo | 2 - 0 | FASFAS |
| 07 Nov 21 | r18 | Alianza FCAlianza FC | 1 - 0 | Isidro MetapánIsidro Metapá |
| |
| 07 Nov 21 | r07 | Atlético MarteAtlético Mart | 0 - 0 | Platense Puerto CortésPlatense Puer |
| |
| 07 Nov 21 | r18 | LimeñoLimeño | 1 - 1 | Santa Tecla FCSanta Tecla F |
| 07 Nov 21 | r18 | Once DeportivoOnce Deportiv | 1 - 2 | ChalatenangoChalatenango |
| |
| 13 Nov 21 | r19 | Atlético MarteAtlético Mart | 2 - 1 | Alianza FCAlianza FC |
| 14 Nov 21 | r19 | Santa Tecla FCSanta Tecla F | 0 - 1 | Platense Puerto CortésPlatense Puer |
| 14 Nov 21 | r19 | ChalatenangoChalatenango | 2 - 0 | JocoroJocoro |
| 14 Nov 21 | r19 | CD ÁguilaCD Águila | 2 - 1 | LimeñoLimeño |
| 14 Nov 21 | r19 | Isidro MetapánIsidro Metapá | 2 - 1 | FirpoFirpo |
| 14 Nov 21 | r19 | FASFAS | 3 - 2 | Once DeportivoOnce Deportiv |
| |
| 17 Nov 21 | r20 | LimeñoLimeño | 0 - 0 | JocoroJocoro |
| 17 Nov 21 | r20 | FASFAS | 1 - 1 | ChalatenangoChalatenango |
| 17 Nov 21 | r20 | Platense Puerto CortésPlatense Puer | 3 - 2 | CD ÁguilaCD Águila |
| 18 Nov 21 | r20 | FirpoFirpo | 2 - 0 | Atlético MarteAtlético Mart |
| 18 Nov 21 | r20 | Alianza FCAlianza FC | 5 - 0 | Santa Tecla FCSanta Tecla F |
| 18 Nov 21 | r20 | Once DeportivoOnce Deportiv | 1 - 1 | Isidro MetapánIsidro Metapá |
| |
| 20 Nov 21 | r21 | JocoroJocoro | 1 - 1 | Platense Puerto CortésPlatense Puer |
| 21 Nov 21 | r21 | Santa Tecla FCSanta Tecla F | 2 - 2 | FirpoFirpo |
| 21 Nov 21 | r21 | CD ÁguilaCD Águila | 0 - 1 | Alianza FCAlianza FC |
| 21 Nov 21 | r21 | LimeñoLimeño | 0 - 3 | ChalatenangoChalatenango |
| 21 Nov 21 | r21 | Atlético MarteAtlético Mart | 1 - 4 | Once DeportivoOnce Deportiv |
| 21 Nov 21 | r21  | Isidro MetapánIsidro Metapá | 1 - 2 | FASFAS |
| |
| 27 Nov 21 | r22 | Platense Puerto CortésPlatense Puer | 0 - 1 | LimeñoLimeño |
| 27 Nov 21 | r22 | Alianza FCAlianza FC | 2 - 0 | JocoroJocoro |
| 27 Nov 21 | r22 | FirpoFirpo | 1 - 0 | CD ÁguilaCD Águila |
| 27 Nov 21 | r22 | Once DeportivoOnce Deportiv | 4 - 3 | Santa Tecla FCSanta Tecla F |
| 27 Nov 21 | r22 | FASFAS | 2 - 2 | Atlético MarteAtlético Mart |
| 27 Nov 21 | r22 | ChalatenangoChalatenango | 1 - 0 | Isidro MetapánIsidro Metapá |
| |
| 01 Dec 21 | r00 | JocoroJocoro | 2 - 3 | Alianza FCAlianza FC |
| 01 Dec 21 | r00 | Platense Puerto CortésPlatense Puer | 2 - 2 | FirpoFirpo |
| 02 Dec 21 | r00 | CD ÁguilaCD Águila | 1 - 1 | Once DeportivoOnce Deportiv |
| 03 Dec 21 | r00 | ChalatenangoChalatenango | 0 - 0 | FASFAS |
| 05 Dec 21 | r00 | Alianza FCAlianza FC | 1 - 0 | JocoroJocoro |
| 05 Dec 21 | r00 | Once DeportivoOnce Deportiv | 0 - 0 | CD ÁguilaCD Águila |
| 05 Dec 21 | r00 | FASFAS | 1 - 0 | ChalatenangoChalatenango |
| 05 Dec 21 | r00 | FirpoFirpo | 1 - 2 | Platense Puerto CortésPlatense Puer |
| 08 Dec 21 | r00 | Once DeportivoOnce Deportiv | 1 - 1 | Alianza FCAlianza FC |
| 10 Dec 21 | r00 | ChalatenangoChalatenango | 1 - 1 | Platense Puerto CortésPlatense Puer |
| 12 Dec 21 | r00 | Alianza FCAlianza FC | 2 - 0 | Once DeportivoOnce Deportiv |
| 12 Dec 21 | r00 | Platense Puerto CortésPlatense Puer | 1 - 0 | ChalatenangoChalatenango |
| 19 Dec 21 | r00 | Alianza FCAlianza FC | 2 - 1 | Platense Puerto CortésPlatense Puer |
| |
| 16 Jan 22 | r01 | CD ÁguilaCD Águila | 0 - 0 | JocoroJocoro |
| 16 Jan 22 | r01 | ChalatenangoChalatenango | 0 - 0 | Atlético MarteAtlético Mart |
| 16 Jan 22 | r01 | Once DeportivoOnce Deportiv | 1 - 1 | FASFAS |
| 16 Jan 22 | r01 | FirpoFirpo | 1 - 0 | LimeñoLimeño |
| 16 Jan 22 | r01 | Alianza FCAlianza FC | 0 - 2 | Isidro MetapánIsidro Metapá |
| 16 Jan 22 | r01 | Platense Puerto CortésPlatense Puer | 0 - 1 | Santa Tecla FCSanta Tecla F |
| |
| 22 Jan 22 | r02 | JocoroJocoro | 3 - 2 | Alianza FCAlianza FC |
| 23 Jan 22 | r02 | Santa Tecla FCSanta Tecla F | 1 - 1 | Once DeportivoOnce Deportiv |
| 23 Jan 22 | r02 | Isidro MetapánIsidro Metapá | 2 - 1 | ChalatenangoChalatenango |
| 23 Jan 22 | r02 | Atlético MarteAtlético Mart | 2 - 1 | FirpoFirpo |
| 23 Jan 22 | r02 | FASFAS | 0 - 3 | CD ÁguilaCD Águila |
| 23 Jan 22 | r02 | LimeñoLimeño | 2 - 1 | Platense Puerto CortésPlatense Puer |
| |
| 26 Jan 22 | r03 | JocoroJocoro | 2 - 2 | FASFAS |
| 26 Jan 22 | r03 | Platense Puerto CortésPlatense Puer | 1 - 1 | Atlético MarteAtlético Mart |
| 26 Jan 22 | r03 | Once DeportivoOnce Deportiv | 3 - 2 | LimeñoLimeño |
| 27 Jan 22 | r03 | CD ÁguilaCD Águila | 4 - 1 | Santa Tecla FCSanta Tecla F |
| 27 Jan 22 | r03 | FirpoFirpo | 0 - 0 | Isidro MetapánIsidro Metapá |
| 27 Jan 22 | r03 | Alianza FCAlianza FC | 3 - 1 | ChalatenangoChalatenango |
| |
| 29 Jan 22 | r04 | Atlético MarteAtlético Mart | 1 - 1 | Once DeportivoOnce Deportiv |
| 30 Jan 22 | r04 | Isidro MetapánIsidro Metapá | 1 - 1 | Platense Puerto CortésPlatense Puer |
| 30 Jan 22 | r04 | ChalatenangoChalatenango | 2 - 1 | FirpoFirpo |
| 30 Jan 22 | r04 | Santa Tecla FCSanta Tecla F | 3 - 0 | JocoroJocoro |
| 30 Jan 22 | r04 | LimeñoLimeño | 0 - 3 | CD ÁguilaCD Águila |
| |
| 04 Feb 22 | r05 | JocoroJocoro | 3 - 0 | LimeñoLimeño |
| 06 Feb 22 | r05 | CD ÁguilaCD Águila | 2 - 1 | Atlético MarteAtlético Mart |
| 06 Feb 22 | r05 | Once DeportivoOnce Deportiv | 0 - 0 | Isidro MetapánIsidro Metapá |
| 06 Feb 22 | r05 | FASFAS | 2 - 0 | Santa Tecla FCSanta Tecla F |
| 06 Feb 22 | r05 | Platense Puerto CortésPlatense Puer | 1 - 1 | ChalatenangoChalatenango |
| 06 Feb 22 | r05 | Alianza FCAlianza FC | 0 - 0 | FirpoFirpo |
| |
| 09 Feb 22 | r06 | LimeñoLimeño | 1 - 1 | FASFAS |
| 09 Feb 22 | r06 | Atlético MarteAtlético Mart | 0 - 0 | JocoroJocoro |
| 10 Feb 22 | r06 | Isidro MetapánIsidro Metapá | 2 - 2 | CD ÁguilaCD Águila |
| 10 Feb 22 | r06 | ChalatenangoChalatenango | 1 - 0 | Once DeportivoOnce Deportiv |
| 10 Feb 22 | r06 | FirpoFirpo | 1 - 1 | Platense Puerto CortésPlatense Puer |
| 10 Feb 22 | r06 | Santa Tecla FCSanta Tecla F | 2 - 3 | Alianza FCAlianza FC |
| |
| 12 Feb 22 | r07 | JocoroJocoro | 2 - 1 | Isidro MetapánIsidro Metapá |
| 13 Feb 22 | r07 | CD ÁguilaCD Águila | 0 - 1 | ChalatenangoChalatenango |
| 13 Feb 22 | r07 | Santa Tecla FCSanta Tecla F | 1 - 1 | LimeñoLimeño |
| 13 Feb 22 | r07 | Once DeportivoOnce Deportiv | 1 - 0 | FirpoFirpo |
| 13 Feb 22 | r07 | FASFAS | 3 - 0 | Atlético MarteAtlético Mart |
| 13 Feb 22 | r07 | Alianza FCAlianza FC | 1 - 0 | Platense Puerto CortésPlatense Puer |
| |
| 19 Feb 22 | r08 | Atlético MarteAtlético Mart | 2 - 1 | Santa Tecla FCSanta Tecla F |
| 20 Feb 22 | r08 | Isidro MetapánIsidro Metapá | 1 - 1 | FASFAS |
| 20 Feb 22 | r08 | ChalatenangoChalatenango | 1 - 0 | JocoroJocoro |
| 20 Feb 22 | r08 | FirpoFirpo | 0 - 0 | CD ÁguilaCD Águila |
| 20 Feb 22 | r08 | LimeñoLimeño | 0 - 0 | Alianza FCAlianza FC |
| 20 Feb 22 | r08 | Platense Puerto CortésPlatense Puer | 1 - 0 | Once DeportivoOnce Deportiv |
| |
| 23 Feb 22 | r09 | LimeñoLimeño | 2 - 0 | Atlético MarteAtlético Mart |
| 23 Feb 22 | r09 | FASFAS | 1 - 3 | ChalatenangoChalatenango |
| 23 Feb 22 | r09 | JocoroJocoro | 1 - 1 | FirpoFirpo |
| |
| 23 Feb 22 | r20 | Once DeportivoOnce Deportiv | 1 - 2 | Alianza FCAlianza FC |
| |
| 24 Feb 22 | r09 | CD ÁguilaCD Águila | 2 - 2 | Platense Puerto CortésPlatense Puer |
| 24 Feb 22 | r09 | Santa Tecla FCSanta Tecla F | 1 - 0 | Isidro MetapánIsidro Metapá |
| |
| 27 Feb 22 | r10 | Isidro MetapánIsidro Metapá | 2 - 0 | LimeñoLimeño |
| 27 Feb 22 | r10 | ChalatenangoChalatenango | 1 - 0 | Santa Tecla FCSanta Tecla F |
| 27 Feb 22 | r10 | FirpoFirpo | 2 - 3 | FASFAS |
| 27 Feb 22 | r10 | Once DeportivoOnce Deportiv | 1 - 4 | CD ÁguilaCD Águila |
| 27 Feb 22 | r10 | Alianza FCAlianza FC | 3 - 2 | Atlético MarteAtlético Mart |
| 27 Feb 22 | r10 | Platense Puerto CortésPlatense Puer | 2 - 0 | JocoroJocoro |
| |
| 03 Mar 22 | r15 | Alianza FCAlianza FC | 1 - 1 | FASFAS |
| |
| 05 Mar 22 | r11 | Atlético MarteAtlético Mart | 0 - 1 | Isidro MetapánIsidro Metapá |
| 05 Mar 22 | r11 | JocoroJocoro | 2 - 1 | Once DeportivoOnce Deportiv |
| 06 Mar 22 | r11 | Santa Tecla FCSanta Tecla F | 1 - 5 | FirpoFirpo |
| 06 Mar 22 | r11 | LimeñoLimeño | 0 - 1 | ChalatenangoChalatenango |
| 06 Mar 22 | r11 | FASFAS | 2 - 1 | Platense Puerto CortésPlatense Puer |
| |
| 06 Mar 22 | r22 | Alianza FCAlianza FC | 0 - 0 | CD ÁguilaCD Águila |
| |
| 12 Mar 22 | r12 | Atlético MarteAtlético Mart | 4 - 2 | ChalatenangoChalatenango |
| 12 Mar 22 | r12 | JocoroJocoro | 0 - 2 | CD ÁguilaCD Águila |
| 13 Mar 22 | r12 | Santa Tecla FCSanta Tecla F | 0 - 1 | Platense Puerto CortésPlatense Puer |
| 13 Mar 22 | r12 | Isidro MetapánIsidro Metapá | 0 - 0 | Alianza FCAlianza FC |
| 13 Mar 22 | r12 | LimeñoLimeño | 3 - 2 | FirpoFirpo |
| 13 Mar 22 | r12 | FASFAS | 0 - 0 | Once DeportivoOnce Deportiv |
| |
| 19 Mar 22 | r13 | Once DeportivoOnce Deportiv | 1 - 0 | Santa Tecla FCSanta Tecla F |
| 20 Mar 22 | r13 | Alianza FCAlianza FC | 2 - 1 | JocoroJocoro |
| 20 Mar 22 | r13 | CD ÁguilaCD Águila | 2 - 0 | FASFAS |
| 20 Mar 22 | r13 | FirpoFirpo | 1 - 2 | Atlético MarteAtlético Mart |
| 20 Mar 22 | r13 | ChalatenangoChalatenango | 1 - 1 | Isidro MetapánIsidro Metapá |
| 20 Mar 22 | r13 | Platense Puerto CortésPlatense Puer | 1 - 0 | LimeñoLimeño |
| |
| 23 Mar 22 | r14 | Atlético MarteAtlético Mart | 0 - 1 | Platense Puerto CortésPlatense Puer |
| 23 Mar 22 | r14 | FASFAS | 2 - 1 | JocoroJocoro |
| 24 Mar 22 | r14 | Isidro MetapánIsidro Metapá | 1 - 1 | FirpoFirpo |
| 24 Mar 22 | r14 | Santa Tecla FCSanta Tecla F | 2 - 2 | CD ÁguilaCD Águila |
| 25 Mar 22 | r14 | ChalatenangoChalatenango | 2 - 0 | Alianza FCAlianza FC |
| 25 Mar 22 | r14 | LimeñoLimeño | 0 - 0 | Once DeportivoOnce Deportiv |
| |
| 02 Apr 22 | r15 | JocoroJocoro | 1 - 0 | Santa Tecla FCSanta Tecla F |
| 03 Apr 22 | r15 | CD ÁguilaCD Águila | 1 - 0 | LimeñoLimeño |
| 03 Apr 22 | r15 | Once DeportivoOnce Deportiv | 1 - 0 | Atlético MarteAtlético Mart |
| 03 Apr 22 | r15 | FirpoFirpo | 1 - 2 | ChalatenangoChalatenango |
| |
| 03 Apr 22 | r04 | FASFAS | 1 - 3 | Alianza FCAlianza FC |
| |
| 03 Apr 22 | r15 | Platense Puerto CortésPlatense Puer | 2 - 1 | Isidro MetapánIsidro Metapá |
| |
| 10 Apr 22 | r16 | Santa Tecla FCSanta Tecla F | 1 - 1 | FASFAS |
| 10 Apr 22 | r16 | Isidro MetapánIsidro Metapá | 2 - 2 | Once DeportivoOnce Deportiv |
| 10 Apr 22 | r16 | ChalatenangoChalatenango | 1 - 2 | Platense Puerto CortésPlatense Puer |
| 10 Apr 22 | r16 | LimeñoLimeño | 2 - 2 | JocoroJocoro |
| 10 Apr 22 | r16 | Atlético MarteAtlético Mart | 0 - 4 | CD ÁguilaCD Águila |
| 10 Apr 22 | r16 | FirpoFirpo | 0 - 1 | Alianza FCAlianza FC |
| |
| 13 Apr 22 | r17 | Once DeportivoOnce Deportiv | 0 - 1 | ChalatenangoChalatenango |
| 13 Apr 22 | r17 | Alianza FCAlianza FC | 2 - 2 | Santa Tecla FCSanta Tecla F |
| 13 Apr 22 | r17 | FASFAS | 1 - 1 | LimeñoLimeño |
| 13 Apr 22 | r17 | JocoroJocoro | 1 - 1 | Atlético MarteAtlético Mart |
| 13 Apr 22 | r17 | Platense Puerto CortésPlatense Puer | 1 - 2 | FirpoFirpo |
| 14 Apr 22 | r17 | CD ÁguilaCD Águila | 1 - 3 | Isidro MetapánIsidro Metapá |
| |
| 17 Apr 22 | r18 | Isidro MetapánIsidro Metapá | 3 - 0 | JocoroJocoro |
| 17 Apr 22 | r18 | ChalatenangoChalatenango | 0 - 0 | CD ÁguilaCD Águila |
| 17 Apr 22 | r18 | LimeñoLimeño | 2 - 0 | Santa Tecla FCSanta Tecla F |
| 17 Apr 22 | r18 | Atlético MarteAtlético Mart | 1 - 1 | FASFAS |
| 17 Apr 22 | r18 | FirpoFirpo | 0 - 0 | Once DeportivoOnce Deportiv |
| 17 Apr 22 | r18 | Platense Puerto CortésPlatense Puer | 0 - 1 | Alianza FCAlianza FC |
| |
| 23 Apr 22 | r19  | JocoroJocoro | 6 - 5 | ChalatenangoChalatenango |
| 24 Apr 22 | r19 | Santa Tecla FCSanta Tecla F | 1 - 1 | Atlético MarteAtlético Mart |
| 24 Apr 22 | r19 | CD ÁguilaCD Águila | 1 - 0 | FirpoFirpo |
| 24 Apr 22 | r19 | Once DeportivoOnce Deportiv | 1 - 2 | Platense Puerto CortésPlatense Puer |
| 24 Apr 22 | r19 | Alianza FCAlianza FC | 4 - 0 | LimeñoLimeño |
| 24 Apr 22 | r19 | FASFAS | 4 - 1 | Isidro MetapánIsidro Metapá |
| |
| 27 Apr 22 | r20 | Atlético MarteAtlético Mart | 0 - 1 | LimeñoLimeño |
| 27 Apr 22 | r20 | Platense Puerto CortésPlatense Puer | 0 - 0 | CD ÁguilaCD Águila |
| 28 Apr 22 | r20 | FirpoFirpo | 1 - 0 | JocoroJocoro |
| 28 Apr 22 | r20 | Isidro MetapánIsidro Metapá | 0 - 0 | Santa Tecla FCSanta Tecla F |
| 28 Apr 22 | r20 | ChalatenangoChalatenango | 3 - 2 | FASFAS |
| |
| 29 Apr 22 | r09 | Alianza FCAlianza FC | 1 - 0 | Once DeportivoOnce Deportiv |
| |
| 30 Apr 22 | r21 | JocoroJocoro | 2 - 2 | Platense Puerto CortésPlatense Puer |
| 01 May 22 | r21 | CD ÁguilaCD Águila | 0 - 1 | Once DeportivoOnce Deportiv |
| 01 May 22 | r21 | Atlético MarteAtlético Mart | 0 - 3 | Alianza FCAlianza FC |
| 01 May 22 | r21 | LimeñoLimeño | 1 - 0 | Isidro MetapánIsidro Metapá |
| 01 May 22 | r21 | FASFAS | 0 - 1 | FirpoFirpo |
| 01 May 22 | r21 | Santa Tecla FCSanta Tecla F | 1 - 0 | ChalatenangoChalatenango |
| |
| 07 May 22 | r11 | CD ÁguilaCD Águila | 3 - 1 | Alianza FCAlianza FC |
| |
| 07 May 22 | r22 | Isidro MetapánIsidro Metapá | 1 - 1 | Atlético MarteAtlético Mart |
| 07 May 22 | r22 | ChalatenangoChalatenango | 0 - 0 | LimeñoLimeño |
| 07 May 22 | r22 | FirpoFirpo | 2 - 0 | Santa Tecla FCSanta Tecla F |
| 07 May 22 | r22 | Platense Puerto CortésPlatense Puer | 1 - 2 | FASFAS |
| 07 May 22 | r22 | Once DeportivoOnce Deportiv | 0 - 1 | JocoroJocoro |
| |
| 10 May 22 | r00 | FASFAS | 0 - 1 | Platense Puerto CortésPlatense Puer |
| 10 May 22 | r00 | JocoroJocoro | 1 - 2 | CD ÁguilaCD Águila |
| 12 May 22 | r00 | FirpoFirpo | 1 - 2 | Alianza FCAlianza FC |
| 12 May 22 | r00 | Isidro MetapánIsidro Metapá | 1 - 0 | ChalatenangoChalatenango |
| 15 May 22 | r00 | CD ÁguilaCD Águila | 1 - 1 | JocoroJocoro |
| 15 May 22 | r00 | ChalatenangoChalatenango | 1 - 2 | Isidro MetapánIsidro Metapá |
| 15 May 22 | r00 | Platense Puerto CortésPlatense Puer | 2 - 1 | FASFAS |
| 15 May 22 | r00 | Alianza FCAlianza FC | 2 - 1 | FirpoFirpo |
| 18 May 22 | r00 | Platense Puerto CortésPlatense Puer | 1 - 0 | Alianza FCAlianza FC |
| 19 May 22 | r00 | Isidro MetapánIsidro Metapá | 1 - 2 | CD ÁguilaCD Águila |
| 22 May 22 | r00 | CD ÁguilaCD Águila | 2 - 1 | Isidro MetapánIsidro Metapá |
| 22 May 22 | r00 | Alianza FCAlianza FC | 3 - 1 | Platense Puerto CortésPlatense Puer |
| 29 May 22 | r00 | Alianza FCAlianza FC | 1 - 1 | CD ÁguilaCD Águila |
| 29 May 22 | r00 | CD ÁguilaCD Águila | 1 - 1 | Alianza FCAlianza FC |
Team 2021-2022 Schedules
Águila
Alianza FC
Cacahuatique
CD Hércules
FAS
Firpo
Fuerte San Francisco
Inter FA
Isidro Metapán
Municipal Limeño
Platense Zacatecoluca
Zacatecoluca
League Table
List
Poster
= Event Thumb 
= Banner Image 
= Fanart Image