| 01 Aug 21 | r01        | ChalatenangoChalatenango | 2 - 2 | Platense Puerto CortésPlatense Puer |
| 01 Aug 21 | r01        | Isidro MetapánIsidro Metapá | 0 - 0 | Atlético MarteAtlético Mart |
| 01 Aug 21 | r01        | Once DeportivoOnce Deportiv | 2 - 2 | CD ÁguilaCD Águila |
| 01 Aug 21 | r01        | FirpoFirpo | 1 - 1 | JocoroJocoro |
| 01 Aug 21 | r01        | FASFAS | 3 - 1 | Santa Tecla FCSanta Tecla F |
| 01 Aug 21 | r01        | Alianza FCAlianza FC | 4 - 1 | LimeñoLimeño |
| |
| 04 Aug 21 | r03        | FASFAS | 4 - 1 | JocoroJocoro |
| |
| 07 Aug 21 | r02        | Atlético MarteAtlético Mart | 0 - 2 | ChalatenangoChalatenango |
| 08 Aug 21 | r02        | LimeñoLimeño | 1 - 1 | FirpoFirpo |
| 08 Aug 21 | r02        | Santa Tecla FCSanta Tecla F | 3 - 0 | Isidro MetapánIsidro Metapá |
| 08 Aug 21 | r02        | CD ÁguilaCD Águila | 1 - 1 | FASFAS |
| 08 Aug 21 | r02        | JocoroJocoro | 3 - 4 | Once DeportivoOnce Deportiv |
| 08 Aug 21 | r02        | Platense Puerto CortésPlatense Puer | 2 - 2 | Alianza FCAlianza FC |
| |
| 10 Aug 21 | r03        | Atlético MarteAtlético Mart | 0 - 1 | Santa Tecla FCSanta Tecla F |
| 11 Aug 21 | r03        | ChalatenangoChalatenango | 2 - 1 | Alianza FCAlianza FC |
| 11 Aug 21 | r03        | Once DeportivoOnce Deportiv | 4 - 1 | LimeñoLimeño |
| 11 Aug 21 | r03        | FirpoFirpo | 3 - 2 | Platense Puerto CortésPlatense Puer |
| 12 Aug 21 | r03        | Isidro MetapánIsidro Metapá | 2 - 2 | CD ÁguilaCD Águila |
| |
| 14 Aug 21 | r04        | JocoroJocoro | 1 - 0 | Isidro MetapánIsidro Metapá |
| 15 Aug 21 | r04        | Santa Tecla FCSanta Tecla F | 1 - 1 | ChalatenangoChalatenango |
| 15 Aug 21 | r04        | LimeñoLimeño | 0 - 3 | FASFAS |
| 15 Aug 21 | r04        | CD ÁguilaCD Águila | 4 - 1 | Atlético MarteAtlético Mart |
| 15 Aug 21 | r04        | Platense Puerto CortésPlatense Puer | 1 - 1 | Once DeportivoOnce Deportiv |
| 15 Aug 21 | r04        | Alianza FCAlianza FC | 2 - 2 | FirpoFirpo |
| |
| 21 Aug 21 | r05        | ChalatenangoChalatenango | 0 - 2 | FirpoFirpo |
| 22 Aug 21 | r05        | Santa Tecla FCSanta Tecla F | 2 - 3 | CD ÁguilaCD Águila |
| 22 Aug 21 | r05        | Isidro MetapánIsidro Metapá | 1 - 0 | LimeñoLimeño |
| 22 Aug 21 | r05        | Atlético MarteAtlético Mart | 2 - 1 | JocoroJocoro |
| 22 Aug 21 | r05        | FASFAS | 0 - 1 | Platense Puerto CortésPlatense Puer |
| |
| 25 Aug 21 | r06        | JocoroJocoro | 2 - 0 | Santa Tecla FCSanta Tecla F |
| 25 Aug 21 | r06        | LimeñoLimeño | 1 - 2 | Atlético MarteAtlético Mart |
| 25 Aug 21 | r06        | Platense Puerto CortésPlatense Puer | 2 - 1 | Isidro MetapánIsidro Metapá |
| 25 Aug 21 | r06        | FirpoFirpo | 2 - 2 | Once DeportivoOnce Deportiv |
| 26 Aug 21 | r06        | CD ÁguilaCD Águila | 2 - 1 | ChalatenangoChalatenango |
| 26 Aug 21 | r06        | Alianza FCAlianza FC | 1 - 0 | FASFAS |
| |
| 29 Aug 21 | r07        | ChalatenangoChalatenango | 1 - 2 | Once DeportivoOnce Deportiv |
| 29 Aug 21 | r07        | CD ÁguilaCD Águila | 2 - 2 | JocoroJocoro |
| 29 Aug 21 | r07        | Santa Tecla FCSanta Tecla F | 1 - 1 | LimeñoLimeño |
| 29 Aug 21 | r07        | Isidro MetapánIsidro Metapá | 1 - 2 | Alianza FCAlianza FC |
| 29 Aug 21 | r07        | FASFAS | 3 - 1 | FirpoFirpo |
| |
| 29 Aug 21 | r18        | Platense Puerto CortésPlatense Puer | 0 - 2 | Atlético MarteAtlético Mart |
| |
| 10 Sep 21 | r16        | Alianza FCAlianza FC | 1 - 0 | Once DeportivoOnce Deportiv |
| |
| 11 Sep 21 | r08        | JocoroJocoro | 3 - 1 | ChalatenangoChalatenango |
| 12 Sep 21 | r08        | LimeñoLimeño | 1 - 0 | CD ÁguilaCD Águila |
| 12 Sep 21 | r08        | FirpoFirpo | 1 - 1 | Isidro MetapánIsidro Metapá |
| 12 Sep 21 | r08        | Once DeportivoOnce Deportiv | 1 - 3 | FASFAS |
| 12 Sep 21 | r08        | Platense Puerto CortésPlatense Puer | 1 - 0 | Santa Tecla FCSanta Tecla F |
| 12 Sep 21 | r08        | Alianza FCAlianza FC | 3 - 1 | Atlético MarteAtlético Mart |
| |
| 15 Sep 21 | r09        | JocoroJocoro | 3 - 1 | LimeñoLimeño |
| 15 Sep 21 | r09        | Atlético MarteAtlético Mart | 1 - 3 | FirpoFirpo |
| 16 Sep 21 | r09        | Santa Tecla FCSanta Tecla F | 0 - 4 | Alianza FCAlianza FC |
| 16 Sep 21 | r09        | ChalatenangoChalatenango | 1 - 2 | FASFAS |
| 16 Sep 21 | r09        | CD ÁguilaCD Águila | 1 - 0 | Platense Puerto CortésPlatense Puer |
| 16 Sep 21 | r09        | Isidro MetapánIsidro Metapá | 0 - 1 | Once DeportivoOnce Deportiv |
| |
| 19 Sep 21 | r10        | ChalatenangoChalatenango | 1 - 1 | LimeñoLimeño |
| 19 Sep 21 | r10        | Alianza FCAlianza FC | 2 - 1 | CD ÁguilaCD Águila |
| 19 Sep 21 | r10        | FirpoFirpo | 0 - 2 | Santa Tecla FCSanta Tecla F |
| 19 Sep 21 | r10        | Once DeportivoOnce Deportiv | 0 - 0 | Atlético MarteAtlético Mart |
| 19 Sep 21 | r10        | Platense Puerto CortésPlatense Puer | 1 - 1 | JocoroJocoro |
| 19 Sep 21 | r10        | FASFAS | 3 - 0 | Isidro MetapánIsidro Metapá |
| |
| 25 Sep 21 | r11        | JocoroJocoro | 3 - 3 | Alianza FCAlianza FC |
| 26 Sep 21 | r11        | CD ÁguilaCD Águila | 1 - 1 | FirpoFirpo |
| 26 Sep 21 | r11        | Santa Tecla FCSanta Tecla F | 0 - 1 | Once DeportivoOnce Deportiv |
| 26 Sep 21 | r11        | Isidro MetapánIsidro Metapá | 1 - 4 | ChalatenangoChalatenango |
| 26 Sep 21 | r11        | Atlético MarteAtlético Mart | 0 - 1 | FASFAS |
| 27 Sep 21 | r11        | LimeñoLimeño | 0 - 1 | Platense Puerto CortésPlatense Puer |
| |
| 02 Oct 21 | r12        | JocoroJocoro | 2 - 1 | FirpoFirpo |
| 02 Oct 21 | r12        | Atlético MarteAtlético Mart | 2 - 0 | Isidro MetapánIsidro Metapá |
| 02 Oct 21 | r12        | Platense Puerto CortésPlatense Puer | 2 - 1 | ChalatenangoChalatenango |
| 02 Oct 21 | r12        | LimeñoLimeño | 0 - 3 | Alianza FCAlianza FC |
| 03 Oct 21 | r12        | Santa Tecla FCSanta Tecla F | 1 - 0 | FASFAS |
| 03 Oct 21 | r12        | CD ÁguilaCD Águila | 1 - 2 | Once DeportivoOnce Deportiv |
| |
| 09 Oct 21 | r14        | LimeñoLimeño | 1 - 1 | Once DeportivoOnce Deportiv |
| 09 Oct 21 | r14        | Platense Puerto CortésPlatense Puer | 1 - 3 | FirpoFirpo |
| |
| 17 Oct 21 | r13        | ChalatenangoChalatenango | 2 - 2 | Atlético MarteAtlético Mart |
| 17 Oct 21 | r13        | FirpoFirpo | 1 - 1 | LimeñoLimeño |
| 17 Oct 21 | r13        | Isidro MetapánIsidro Metapá | 1 - 1 | Santa Tecla FCSanta Tecla F |
| 17 Oct 21 | r13        | Once DeportivoOnce Deportiv | 2 - 2 | JocoroJocoro |
| 17 Oct 21 | r13        | FASFAS | 0 - 1 | CD ÁguilaCD Águila |
| 17 Oct 21 | r13        | Alianza FCAlianza FC | 4 - 0 | Platense Puerto CortésPlatense Puer |
| |
| 20 Oct 21 | r14        | JocoroJocoro | 0 - 0 | FASFAS |
| 21 Oct 21 | r14        | Santa Tecla FCSanta Tecla F | 0 - 0 | Atlético MarteAtlético Mart |
| 21 Oct 21 | r14        | CD ÁguilaCD Águila | 4 - 0 | Isidro MetapánIsidro Metapá |
| 21 Oct 21 | r14        | Alianza FCAlianza FC | 1 - 0 | ChalatenangoChalatenango |
| |
| 24 Oct 21 | r15        | ChalatenangoChalatenango | 0 - 2 | Santa Tecla FCSanta Tecla F |
| 24 Oct 21 | r15        | Isidro MetapánIsidro Metapá | 1 - 1 | JocoroJocoro |
| 24 Oct 21 | r15        | Atlético MarteAtlético Mart | 1 - 2 | CD ÁguilaCD Águila |
| 24 Oct 21 | r15        | Once DeportivoOnce Deportiv | 1 - 1 | Platense Puerto CortésPlatense Puer |
| 24 Oct 21 | r15        | FirpoFirpo | 2 - 1 | Alianza FCAlianza FC |
| 24 Oct 21 | r15        | FASFAS | 2 - 1 | LimeñoLimeño |
| |
| 30 Oct 21 | r16        | JocoroJocoro | 1 - 1 | Atlético MarteAtlético Mart |
| 30 Oct 21 | r16        | LimeñoLimeño | 2 - 2 | Isidro MetapánIsidro Metapá |
| |
| 30 Oct 21 | r05        | Once DeportivoOnce Deportiv | 2 - 3 | Alianza FCAlianza FC |
| |
| 30 Oct 21 | r16        | Platense Puerto CortésPlatense Puer | 0 - 0 | FASFAS |
| 31 Oct 21 | r16        | CD ÁguilaCD Águila | 2 - 0 | Santa Tecla FCSanta Tecla F |
| 31 Oct 21 | r16        | FirpoFirpo | 4 - 2 | ChalatenangoChalatenango |
| |
| 02 Nov 21 | r17        | Atlético MarteAtlético Mart | 2 - 0 | LimeñoLimeño |
| 02 Nov 21 | r17        | FASFAS | 0 - 1 | Alianza FCAlianza FC |
| 02 Nov 21 | r17        | Once DeportivoOnce Deportiv | 1 - 0 | FirpoFirpo |
| 03 Nov 21 | r17        | ChalatenangoChalatenango | 1 - 1 | CD ÁguilaCD Águila |
| 03 Nov 21 | r17        | Santa Tecla FCSanta Tecla F | 2 - 1 | JocoroJocoro |
| 03 Nov 21 | r17        | Isidro MetapánIsidro Metapá | 1 - 0 | Platense Puerto CortésPlatense Puer |
| |
| 06 Nov 21 | r18        | JocoroJocoro | 2 - 2 | CD ÁguilaCD Águila |
| 07 Nov 21 | r18        | FirpoFirpo | 2 - 0 | FASFAS |
| 07 Nov 21 | r18        | Alianza FCAlianza FC | 1 - 0 | Isidro MetapánIsidro Metapá |
| |
| 07 Nov 21 | r07        | Atlético MarteAtlético Mart | 0 - 0 | Platense Puerto CortésPlatense Puer |
| |
| 07 Nov 21 | r18        | LimeñoLimeño | 1 - 1 | Santa Tecla FCSanta Tecla F |
| 07 Nov 21 | r18        | Once DeportivoOnce Deportiv | 1 - 2 | ChalatenangoChalatenango |
| |
| 13 Nov 21 | r19        | Atlético MarteAtlético Mart | 2 - 1 | Alianza FCAlianza FC |
| 14 Nov 21 | r19        | Santa Tecla FCSanta Tecla F | 0 - 1 | Platense Puerto CortésPlatense Puer |
| 14 Nov 21 | r19        | ChalatenangoChalatenango | 2 - 0 | JocoroJocoro |
| 14 Nov 21 | r19        | CD ÁguilaCD Águila | 2 - 1 | LimeñoLimeño |
| 14 Nov 21 | r19        | Isidro MetapánIsidro Metapá | 2 - 1 | FirpoFirpo |
| 14 Nov 21 | r19        | FASFAS | 3 - 2 | Once DeportivoOnce Deportiv |
| |
| 17 Nov 21 | r20        | LimeñoLimeño | 0 - 0 | JocoroJocoro |
| 17 Nov 21 | r20        | FASFAS | 1 - 1 | ChalatenangoChalatenango |
| 17 Nov 21 | r20        | Platense Puerto CortésPlatense Puer | 3 - 2 | CD ÁguilaCD Águila |
| 18 Nov 21 | r20        | FirpoFirpo | 2 - 0 | Atlético MarteAtlético Mart |
| 18 Nov 21 | r20        | Alianza FCAlianza FC | 5 - 0 | Santa Tecla FCSanta Tecla F |
| 18 Nov 21 | r20        | Once DeportivoOnce Deportiv | 1 - 1 | Isidro MetapánIsidro Metapá |
| |
| 20 Nov 21 | r21        | JocoroJocoro | 1 - 1 | Platense Puerto CortésPlatense Puer |
| 21 Nov 21 | r21        | Santa Tecla FCSanta Tecla F | 2 - 2 | FirpoFirpo |
| 21 Nov 21 | r21        | CD ÁguilaCD Águila | 0 - 1 | Alianza FCAlianza FC |
| 21 Nov 21 | r21        | LimeñoLimeño | 0 - 3 | ChalatenangoChalatenango |
| 21 Nov 21 | r21        | Atlético MarteAtlético Mart | 1 - 4 | Once DeportivoOnce Deportiv |
| 21 Nov 21 | r21        | Isidro MetapánIsidro Metapá | 1 - 2 | FASFAS |
| |
| 27 Nov 21 | r22        | Platense Puerto CortésPlatense Puer | 0 - 1 | LimeñoLimeño |
| 27 Nov 21 | r22        | Alianza FCAlianza FC | 2 - 0 | JocoroJocoro |
| 27 Nov 21 | r22        | FirpoFirpo | 1 - 0 | CD ÁguilaCD Águila |
| 27 Nov 21 | r22        | Once DeportivoOnce Deportiv | 4 - 3 | Santa Tecla FCSanta Tecla F |
| 27 Nov 21 | r22        | FASFAS | 2 - 2 | Atlético MarteAtlético Mart |
| 27 Nov 21 | r22        | ChalatenangoChalatenango | 1 - 0 | Isidro MetapánIsidro Metapá |
| |
| 01 Dec 21 | r00        | JocoroJocoro | 2 - 3 | Alianza FCAlianza FC |
| 01 Dec 21 | r00        | Platense Puerto CortésPlatense Puer | 2 - 2 | FirpoFirpo |
| 02 Dec 21 | r00        | CD ÁguilaCD Águila | 1 - 1 | Once DeportivoOnce Deportiv |
| 03 Dec 21 | r00        | ChalatenangoChalatenango | 0 - 0 | FASFAS |
| 05 Dec 21 | r00        | Alianza FCAlianza FC | 1 - 0 | JocoroJocoro |
| 05 Dec 21 | r00        | Once DeportivoOnce Deportiv | 0 - 0 | CD ÁguilaCD Águila |
| 05 Dec 21 | r00        | FASFAS | 1 - 0 | ChalatenangoChalatenango |
| 05 Dec 21 | r00        | FirpoFirpo | 1 - 2 | Platense Puerto CortésPlatense Puer |
| 08 Dec 21 | r00        | Once DeportivoOnce Deportiv | 1 - 1 | Alianza FCAlianza FC |
| 10 Dec 21 | r00        | ChalatenangoChalatenango | 1 - 1 | Platense Puerto CortésPlatense Puer |
| 12 Dec 21 | r00        | Alianza FCAlianza FC | 2 - 0 | Once DeportivoOnce Deportiv |
| 12 Dec 21 | r00        | Platense Puerto CortésPlatense Puer | 1 - 0 | ChalatenangoChalatenango |
| 19 Dec 21 | r00        | Alianza FCAlianza FC | 2 - 1 | Platense Puerto CortésPlatense Puer |
| |
| 16 Jan 22 | r01        | CD ÁguilaCD Águila | 0 - 0 | JocoroJocoro |
| 16 Jan 22 | r01        | ChalatenangoChalatenango | 0 - 0 | Atlético MarteAtlético Mart |
| 16 Jan 22 | r01        | Once DeportivoOnce Deportiv | 1 - 1 | FASFAS |
| 16 Jan 22 | r01        | FirpoFirpo | 1 - 0 | LimeñoLimeño |
| 16 Jan 22 | r01        | Alianza FCAlianza FC | 0 - 2 | Isidro MetapánIsidro Metapá |
| 16 Jan 22 | r01        | Platense Puerto CortésPlatense Puer | 0 - 1 | Santa Tecla FCSanta Tecla F |
| |
| 22 Jan 22 | r02        | JocoroJocoro | 3 - 2 | Alianza FCAlianza FC |
| 23 Jan 22 | r02        | Santa Tecla FCSanta Tecla F | 1 - 1 | Once DeportivoOnce Deportiv |
| 23 Jan 22 | r02        | Isidro MetapánIsidro Metapá | 2 - 1 | ChalatenangoChalatenango |
| 23 Jan 22 | r02        | Atlético MarteAtlético Mart | 2 - 1 | FirpoFirpo |
| 23 Jan 22 | r02        | FASFAS | 0 - 3 | CD ÁguilaCD Águila |
| 23 Jan 22 | r02        | LimeñoLimeño | 2 - 1 | Platense Puerto CortésPlatense Puer |
| |
| 26 Jan 22 | r03        | JocoroJocoro | 2 - 2 | FASFAS |
| 26 Jan 22 | r03        | Platense Puerto CortésPlatense Puer | 1 - 1 | Atlético MarteAtlético Mart |
| 26 Jan 22 | r03        | Once DeportivoOnce Deportiv | 3 - 2 | LimeñoLimeño |
| 27 Jan 22 | r03        | CD ÁguilaCD Águila | 4 - 1 | Santa Tecla FCSanta Tecla F |
| 27 Jan 22 | r03        | FirpoFirpo | 0 - 0 | Isidro MetapánIsidro Metapá |
| 27 Jan 22 | r03        | Alianza FCAlianza FC | 3 - 1 | ChalatenangoChalatenango |
| |
| 29 Jan 22 | r04        | Atlético MarteAtlético Mart | 1 - 1 | Once DeportivoOnce Deportiv |
| 30 Jan 22 | r04        | Isidro MetapánIsidro Metapá | 1 - 1 | Platense Puerto CortésPlatense Puer |
| 30 Jan 22 | r04        | ChalatenangoChalatenango | 2 - 1 | FirpoFirpo |
| 30 Jan 22 | r04        | Santa Tecla FCSanta Tecla F | 3 - 0 | JocoroJocoro |
| 30 Jan 22 | r04        | LimeñoLimeño | 0 - 3 | CD ÁguilaCD Águila |
| |
| 04 Feb 22 | r05        | JocoroJocoro | 3 - 0 | LimeñoLimeño |
| 06 Feb 22 | r05        | CD ÁguilaCD Águila | 2 - 1 | Atlético MarteAtlético Mart |
| 06 Feb 22 | r05        | Once DeportivoOnce Deportiv | 0 - 0 | Isidro MetapánIsidro Metapá |
| 06 Feb 22 | r05        | FASFAS | 2 - 0 | Santa Tecla FCSanta Tecla F |
| 06 Feb 22 | r05        | Platense Puerto CortésPlatense Puer | 1 - 1 | ChalatenangoChalatenango |
| 06 Feb 22 | r05        | Alianza FCAlianza FC | 0 - 0 | FirpoFirpo |
| |
| 09 Feb 22 | r06        | LimeñoLimeño | 1 - 1 | FASFAS |
| 09 Feb 22 | r06        | Atlético MarteAtlético Mart | 0 - 0 | JocoroJocoro |
| 10 Feb 22 | r06        | Isidro MetapánIsidro Metapá | 2 - 2 | CD ÁguilaCD Águila |
| 10 Feb 22 | r06        | ChalatenangoChalatenango | 1 - 0 | Once DeportivoOnce Deportiv |
| 10 Feb 22 | r06        | FirpoFirpo | 1 - 1 | Platense Puerto CortésPlatense Puer |
| 10 Feb 22 | r06        | Santa Tecla FCSanta Tecla F | 2 - 3 | Alianza FCAlianza FC |
| |
| 12 Feb 22 | r07        | JocoroJocoro | 2 - 1 | Isidro MetapánIsidro Metapá |
| 13 Feb 22 | r07        | CD ÁguilaCD Águila | 0 - 1 | ChalatenangoChalatenango |
| 13 Feb 22 | r07        | Santa Tecla FCSanta Tecla F | 1 - 1 | LimeñoLimeño |
| 13 Feb 22 | r07        | Once DeportivoOnce Deportiv | 1 - 0 | FirpoFirpo |
| 13 Feb 22 | r07        | FASFAS | 3 - 0 | Atlético MarteAtlético Mart |
| 13 Feb 22 | r07        | Alianza FCAlianza FC | 1 - 0 | Platense Puerto CortésPlatense Puer |
| |
| 19 Feb 22 | r08        | Atlético MarteAtlético Mart | 2 - 1 | Santa Tecla FCSanta Tecla F |
| 20 Feb 22 | r08        | Isidro MetapánIsidro Metapá | 1 - 1 | FASFAS |
| 20 Feb 22 | r08        | ChalatenangoChalatenango | 1 - 0 | JocoroJocoro |
| 20 Feb 22 | r08        | FirpoFirpo | 0 - 0 | CD ÁguilaCD Águila |
| 20 Feb 22 | r08        | LimeñoLimeño | 0 - 0 | Alianza FCAlianza FC |
| 20 Feb 22 | r08        | Platense Puerto CortésPlatense Puer | 1 - 0 | Once DeportivoOnce Deportiv |
| |
| 23 Feb 22 | r09        | LimeñoLimeño | 2 - 0 | Atlético MarteAtlético Mart |
| 23 Feb 22 | r09        | FASFAS | 1 - 3 | ChalatenangoChalatenango |
| 23 Feb 22 | r09        | JocoroJocoro | 1 - 1 | FirpoFirpo |
| |
| 23 Feb 22 | r20        | Once DeportivoOnce Deportiv | 1 - 2 | Alianza FCAlianza FC |
| |
| 24 Feb 22 | r09        | CD ÁguilaCD Águila | 2 - 2 | Platense Puerto CortésPlatense Puer |
| 24 Feb 22 | r09        | Santa Tecla FCSanta Tecla F | 1 - 0 | Isidro MetapánIsidro Metapá |
| |
| 27 Feb 22 | r10        | Isidro MetapánIsidro Metapá | 2 - 0 | LimeñoLimeño |
| 27 Feb 22 | r10        | ChalatenangoChalatenango | 1 - 0 | Santa Tecla FCSanta Tecla F |
| 27 Feb 22 | r10        | FirpoFirpo | 2 - 3 | FASFAS |
| 27 Feb 22 | r10        | Once DeportivoOnce Deportiv | 1 - 4 | CD ÁguilaCD Águila |
| 27 Feb 22 | r10        | Alianza FCAlianza FC | 3 - 2 | Atlético MarteAtlético Mart |
| 27 Feb 22 | r10        | Platense Puerto CortésPlatense Puer | 2 - 0 | JocoroJocoro |
| |
| 03 Mar 22 | r15        | Alianza FCAlianza FC | 1 - 1 | FASFAS |
| |
| 05 Mar 22 | r11        | Atlético MarteAtlético Mart | 0 - 1 | Isidro MetapánIsidro Metapá |
| 05 Mar 22 | r11        | JocoroJocoro | 2 - 1 | Once DeportivoOnce Deportiv |
| 06 Mar 22 | r11        | Santa Tecla FCSanta Tecla F | 1 - 5 | FirpoFirpo |
| 06 Mar 22 | r11        | LimeñoLimeño | 0 - 1 | ChalatenangoChalatenango |
| 06 Mar 22 | r11        | FASFAS | 2 - 1 | Platense Puerto CortésPlatense Puer |
| |
| 06 Mar 22 | r22        | Alianza FCAlianza FC | 0 - 0 | CD ÁguilaCD Águila |
| |
| 12 Mar 22 | r12        | Atlético MarteAtlético Mart | 4 - 2 | ChalatenangoChalatenango |
| 12 Mar 22 | r12        | JocoroJocoro | 0 - 2 | CD ÁguilaCD Águila |
| 13 Mar 22 | r12        | Santa Tecla FCSanta Tecla F | 0 - 1 | Platense Puerto CortésPlatense Puer |
| 13 Mar 22 | r12        | Isidro MetapánIsidro Metapá | 0 - 0 | Alianza FCAlianza FC |
| 13 Mar 22 | r12        | LimeñoLimeño | 3 - 2 | FirpoFirpo |
| 13 Mar 22 | r12        | FASFAS | 0 - 0 | Once DeportivoOnce Deportiv |
| |
| 19 Mar 22 | r13        | Once DeportivoOnce Deportiv | 1 - 0 | Santa Tecla FCSanta Tecla F |
| 20 Mar 22 | r13        | Alianza FCAlianza FC | 2 - 1 | JocoroJocoro |
| 20 Mar 22 | r13        | CD ÁguilaCD Águila | 2 - 0 | FASFAS |
| 20 Mar 22 | r13        | FirpoFirpo | 1 - 2 | Atlético MarteAtlético Mart |
| 20 Mar 22 | r13        | ChalatenangoChalatenango | 1 - 1 | Isidro MetapánIsidro Metapá |
| 20 Mar 22 | r13        | Platense Puerto CortésPlatense Puer | 1 - 0 | LimeñoLimeño |
| |
| 23 Mar 22 | r14        | Atlético MarteAtlético Mart | 0 - 1 | Platense Puerto CortésPlatense Puer |
| 23 Mar 22 | r14        | FASFAS | 2 - 1 | JocoroJocoro |
| 24 Mar 22 | r14        | Isidro MetapánIsidro Metapá | 1 - 1 | FirpoFirpo |
| 24 Mar 22 | r14        | Santa Tecla FCSanta Tecla F | 2 - 2 | CD ÁguilaCD Águila |
| 25 Mar 22 | r14        | ChalatenangoChalatenango | 2 - 0 | Alianza FCAlianza FC |
| 25 Mar 22 | r14        | LimeñoLimeño | 0 - 0 | Once DeportivoOnce Deportiv |
| |
| 02 Apr 22 | r15        | JocoroJocoro | 1 - 0 | Santa Tecla FCSanta Tecla F |
| 03 Apr 22 | r15        | CD ÁguilaCD Águila | 1 - 0 | LimeñoLimeño |
| 03 Apr 22 | r15        | Once DeportivoOnce Deportiv | 1 - 0 | Atlético MarteAtlético Mart |
| 03 Apr 22 | r15        | FirpoFirpo | 1 - 2 | ChalatenangoChalatenango |
| |
| 03 Apr 22 | r04        | FASFAS | 1 - 3 | Alianza FCAlianza FC |
| |
| 03 Apr 22 | r15        | Platense Puerto CortésPlatense Puer | 2 - 1 | Isidro MetapánIsidro Metapá |
| |
| 10 Apr 22 | r16        | Santa Tecla FCSanta Tecla F | 1 - 1 | FASFAS |
| 10 Apr 22 | r16        | Isidro MetapánIsidro Metapá | 2 - 2 | Once DeportivoOnce Deportiv |
| 10 Apr 22 | r16        | ChalatenangoChalatenango | 1 - 2 | Platense Puerto CortésPlatense Puer |
| 10 Apr 22 | r16        | LimeñoLimeño | 2 - 2 | JocoroJocoro |
| 10 Apr 22 | r16        | Atlético MarteAtlético Mart | 0 - 4 | CD ÁguilaCD Águila |
| 10 Apr 22 | r16        | FirpoFirpo | 0 - 1 | Alianza FCAlianza FC |
| |
| 13 Apr 22 | r17        | Once DeportivoOnce Deportiv | 0 - 1 | ChalatenangoChalatenango |
| 13 Apr 22 | r17        | Alianza FCAlianza FC | 2 - 2 | Santa Tecla FCSanta Tecla F |
| 13 Apr 22 | r17        | FASFAS | 1 - 1 | LimeñoLimeño |
| 13 Apr 22 | r17        | JocoroJocoro | 1 - 1 | Atlético MarteAtlético Mart |
| 13 Apr 22 | r17        | Platense Puerto CortésPlatense Puer | 1 - 2 | FirpoFirpo |
| 14 Apr 22 | r17        | CD ÁguilaCD Águila | 1 - 3 | Isidro MetapánIsidro Metapá |
| |
| 17 Apr 22 | r18        | Isidro MetapánIsidro Metapá | 3 - 0 | JocoroJocoro |
| 17 Apr 22 | r18        | ChalatenangoChalatenango | 0 - 0 | CD ÁguilaCD Águila |
| 17 Apr 22 | r18        | LimeñoLimeño | 2 - 0 | Santa Tecla FCSanta Tecla F |
| 17 Apr 22 | r18        | Atlético MarteAtlético Mart | 1 - 1 | FASFAS |
| 17 Apr 22 | r18        | FirpoFirpo | 0 - 0 | Once DeportivoOnce Deportiv |
| 17 Apr 22 | r18        | Platense Puerto CortésPlatense Puer | 0 - 1 | Alianza FCAlianza FC |
| |
| 23 Apr 22 | r19        | JocoroJocoro | 6 - 5 | ChalatenangoChalatenango |
| 24 Apr 22 | r19        | Santa Tecla FCSanta Tecla F | 1 - 1 | Atlético MarteAtlético Mart |
| 24 Apr 22 | r19        | CD ÁguilaCD Águila | 1 - 0 | FirpoFirpo |
| 24 Apr 22 | r19        | Once DeportivoOnce Deportiv | 1 - 2 | Platense Puerto CortésPlatense Puer |
| 24 Apr 22 | r19        | Alianza FCAlianza FC | 4 - 0 | LimeñoLimeño |
| 24 Apr 22 | r19        | FASFAS | 4 - 1 | Isidro MetapánIsidro Metapá |
| |
| 27 Apr 22 | r20        | Atlético MarteAtlético Mart | 0 - 1 | LimeñoLimeño |
| 27 Apr 22 | r20        | Platense Puerto CortésPlatense Puer | 0 - 0 | CD ÁguilaCD Águila |
| 28 Apr 22 | r20        | FirpoFirpo | 1 - 0 | JocoroJocoro |
| 28 Apr 22 | r20        | Isidro MetapánIsidro Metapá | 0 - 0 | Santa Tecla FCSanta Tecla F |
| 28 Apr 22 | r20        | ChalatenangoChalatenango | 3 - 2 | FASFAS |
| |
| 29 Apr 22 | r09        | Alianza FCAlianza FC | 1 - 0 | Once DeportivoOnce Deportiv |
| |
| 30 Apr 22 | r21        | JocoroJocoro | 2 - 2 | Platense Puerto CortésPlatense Puer |
| 01 May 22 | r21        | CD ÁguilaCD Águila | 0 - 1 | Once DeportivoOnce Deportiv |
| 01 May 22 | r21        | Atlético MarteAtlético Mart | 0 - 3 | Alianza FCAlianza FC |
| 01 May 22 | r21        | LimeñoLimeño | 1 - 0 | Isidro MetapánIsidro Metapá |
| 01 May 22 | r21        | FASFAS | 0 - 1 | FirpoFirpo |
| 01 May 22 | r21        | Santa Tecla FCSanta Tecla F | 1 - 0 | ChalatenangoChalatenango |
| |
| 07 May 22 | r11        | CD ÁguilaCD Águila | 3 - 1 | Alianza FCAlianza FC |
| |
| 07 May 22 | r22        | Isidro MetapánIsidro Metapá | 1 - 1 | Atlético MarteAtlético Mart |
| 07 May 22 | r22        | ChalatenangoChalatenango | 0 - 0 | LimeñoLimeño |
| 07 May 22 | r22        | FirpoFirpo | 2 - 0 | Santa Tecla FCSanta Tecla F |
| 07 May 22 | r22        | Platense Puerto CortésPlatense Puer | 1 - 2 | FASFAS |
| 07 May 22 | r22        | Once DeportivoOnce Deportiv | 0 - 1 | JocoroJocoro |
| |
| 10 May 22 | r00        | FASFAS | 0 - 1 | Platense Puerto CortésPlatense Puer |
| 10 May 22 | r00        | JocoroJocoro | 1 - 2 | CD ÁguilaCD Águila |
| 12 May 22 | r00        | FirpoFirpo | 1 - 2 | Alianza FCAlianza FC |
| 12 May 22 | r00        | Isidro MetapánIsidro Metapá | 1 - 0 | ChalatenangoChalatenango |
| 15 May 22 | r00        | CD ÁguilaCD Águila | 1 - 1 | JocoroJocoro |
| 15 May 22 | r00        | ChalatenangoChalatenango | 1 - 2 | Isidro MetapánIsidro Metapá |
| 15 May 22 | r00        | Platense Puerto CortésPlatense Puer | 2 - 1 | FASFAS |
| 15 May 22 | r00        | Alianza FCAlianza FC | 2 - 1 | FirpoFirpo |
| 18 May 22 | r00        | Platense Puerto CortésPlatense Puer | 1 - 0 | Alianza FCAlianza FC |
| 19 May 22 | r00        | Isidro MetapánIsidro Metapá | 1 - 2 | CD ÁguilaCD Águila |
| 22 May 22 | r00        | CD ÁguilaCD Águila | 2 - 1 | Isidro MetapánIsidro Metapá |
| 22 May 22 | r00        | Alianza FCAlianza FC | 3 - 1 | Platense Puerto CortésPlatense Puer |
| 29 May 22 | r00        | Alianza FCAlianza FC | 1 - 1 | CD ÁguilaCD Águila |
| 29 May 22 | r00        | CD ÁguilaCD Águila | 1 - 1 | Alianza FCAlianza FC |