| 21 Jul 22 | r01    | GuadalupeGuadalupe | 1 - 2 | Sporting San JoseSporting San |
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| 24 Jul 22 | r02 | CS HeredianoCS Herediano | 1 - 0 | GuadalupeGuadalupe |
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| 31 Jul 22 | r03 | Santos de GuápilesSantos de Guá | 3 - 3 | GuadalupeGuadalupe |
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| 07 Aug 22 | r04 | GuadalupeGuadalupe | 1 - 3 | AlajuelenseAlajuelense |
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| 11 Aug 22 | r05 | GuanacastecaGuanacasteca | 1 - 2 | GuadalupeGuadalupe |
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| 15 Aug 22 | r06 | GuadalupeGuadalupe | 1 - 0 | GuanacastecaGuanacasteca |
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| 22 Aug 22 | r07 | Sporting San JoseSporting San | 4 - 2 | GuadalupeGuadalupe |
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| 28 Aug 22 | r08 | GuadalupeGuadalupe | 3 - 0 | Santos de GuápilesSantos de Guá |
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| 01 Sep 22 | r09 | AlajuelenseAlajuelense | 1 - 0 | GuadalupeGuadalupe |
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| 04 Sep 22 | r10 | GuadalupeGuadalupe | 0 - 5 | CS HeredianoCS Herediano |
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| 11 Sep 22 | r11 | Pérez ZeledónPérez Zeledón | 2 - 1 | GuadalupeGuadalupe |
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| 18 Sep 22 | r12  | CartaginésCartaginés | 3 - 0 | GuadalupeGuadalupe |
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| 22 Sep 22 | r13 | GuadalupeGuadalupe | 2 - 1 | AD San CarlosAD San Carlos |
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| 25 Sep 22 | r14 | GuadalupeGuadalupe | 0 - 1 | GreciaGrecia |
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| 29 Sep 22 | r15 | PuntarenasPuntarenas | 0 - 2 | GuadalupeGuadalupe |
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| 03 Oct 22 | r16 | GuadalupeGuadalupe | 1 - 2 | Deportivo SaprissaDeportivo Sap |
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| 15 Jan 23 | r01 | CS HeredianoCS Herediano | 1 - 0 | GuadalupeGuadalupe |
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| 22 Jan 23 | r02 | GuadalupeGuadalupe | 0 - 1 | Deportivo SaprissaDeportivo Sap |
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| 26 Jan 23 | r03 | Sporting San JoseSporting San | 2 - 0 | GuadalupeGuadalupe |
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| 30 Jan 23 | r04 | GuadalupeGuadalupe | 5 - 1 | CartaginésCartaginés |
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| 05 Feb 23 | r05 | GuadalupeGuadalupe | 0 - 1 | PuntarenasPuntarenas |
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| 08 Feb 23 | r06 | GreciaGrecia | 3 - 4 | GuadalupeGuadalupe |
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| 12 Feb 23 | r07 | GuadalupeGuadalupe | 1 - 1 | GuanacastecaGuanacasteca |
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| 20 Feb 23 | r08 | AD San CarlosAD San Carlos | 2 - 0 | GuadalupeGuadalupe |
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| 23 Feb 23 | r09 | GuadalupeGuadalupe | 1 - 1 | Pérez ZeledónPérez Zeledón |
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| 26 Feb 23 | r10 | GuadalupeGuadalupe | 1 - 3 | Santos de GuápilesSantos de Guá |
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| 04 Mar 23 | r11 | AlajuelenseAlajuelense | 4 - 0 | GuadalupeGuadalupe |
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| 13 Mar 23 | r12 | GuadalupeGuadalupe | 0 - 4 | CS HeredianoCS Herediano |
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| 19 Mar 23 | r13 | Deportivo SaprissaDeportivo Sap | 2 - 1 | GuadalupeGuadalupe |
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| 24 Mar 23 | r14 | GuadalupeGuadalupe | 1 - 1 | Sporting San JoseSporting San |
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| 31 Mar 23 | r15 | CartaginésCartaginés | 3 - 2 | GuadalupeGuadalupe |
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| 04 Apr 23 | r16 | PuntarenasPuntarenas | 1 - 2 | GuadalupeGuadalupe |
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| 11 Apr 23 | r17 | GuadalupeGuadalupe | 1 - 1 | GreciaGrecia |
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| 16 Apr 23 | r18 | GuanacastecaGuanacasteca | 2 - 0 | GuadalupeGuadalupe |
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| 20 Apr 23 | r19 | GuadalupeGuadalupe | 2 - 3 | AD San CarlosAD San Carlos |
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| 23 Apr 23 | r20 | Pérez ZeledónPérez Zeledón | 3 - 1 | GuadalupeGuadalupe |
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| 30 Apr 23 | r21 | Santos de GuápilesSantos de Guá | 1 - 3 | GuadalupeGuadalupe |
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| 07 May 23 | r22 | GuadalupeGuadalupe | 3 - 2 | AlajuelenseAlajuelense |
Team 2022-2023 Schedules
AD San Carlos
Alajuelense
Cartaginés
Deportivo Saprissa
Guadalupe
Herediano
Municipal Liberia
Pérez Zeledón
Puntarenas
Sporting San Jose
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