| 23 Oct 21 | r28        | FC LidaFC Lida | 1 - 7 | Lokomotiv GomelLokomotiv Gom |
| 23 Oct 21 | r28        | BaranovichiBaranovichi | 3 - 3 | Shakhter PetrikovShakhter Petr |
| 23 Oct 21 | r28        | FC Volna PinskFC Volna Pins | 2 - 1 | FC OrshaFC Orsha |
| 24 Oct 21 | r28        | FC Belshina BobruiskFC Belshina B | 0 - 3 | FK Arsenal DzerzhinskFK Arsenal Dz |
| 24 Oct 21 | r28        | FC Belshina BobruiskFC Belshina B | 0 - 3 | FK Arsenal DzerzhinskFK Arsenal Dz |
| 24 Oct 21 | r28        | Naftan NovopolotskNaftan Novopo | 0 - 0 | NFK MinskNFK Minsk |
| 24 Oct 21 | r28        | Naftan Novopolotsk Naftan Novopo | 0 - 0 | NFK MinskNFK Minsk |
| 24 Oct 21 | r28        | FC Dnepr MogilevFC Dnepr Mogi | 1 - 0 | FC SlonimFC Slonim |
| 24 Oct 21 | r28        | FC Dnepr MogilevFC Dnepr Mogi | 1 - 0 | FC SlonimFC Slonim |