| 11 Jul 22 | r01  | DiriangénDiriangén | 2 - 0 | MatagalpaMatagalpa |
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| 17 Jul 22 | r02 | MatagalpaMatagalpa | 0 - 0 | JalapaJalapa |
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| 24 Jul 22 | r03 | Juventus ManaguaJuventus Mana | 3 - 2 | MatagalpaMatagalpa |
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| 31 Jul 22 | r04 | MatagalpaMatagalpa | 1 - 2 | Deportivo SebacoDeportivo Seb |
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| 07 Aug 22 | r05 | CD OcotalCD Ocotal | 1 - 1 | MatagalpaMatagalpa |
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| 11 Aug 22 | r06 | MatagalpaMatagalpa | 1 - 0 | CD Walter FerretiCD Walter Fer |
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| 14 Aug 22 | r07 | UNAM ManaguaUNAM Managua | 3 - 0 | MatagalpaMatagalpa |
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| 21 Aug 22 | r08 | MatagalpaMatagalpa | 1 - 0 | Managua FCManagua FC |
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| 28 Aug 22 | r09  | MatagalpaMatagalpa | 0 - 3 | Real Estelí FCReal Estelí F |
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| 04 Sep 22 | r10 | MatagalpaMatagalpa | 2 - 3 | DiriangénDiriangén |
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| 11 Sep 22 | r11 | JalapaJalapa | 2 - 1 | MatagalpaMatagalpa |
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| 01 Oct 22 | r12 | MatagalpaMatagalpa | 2 - 5 | Juventus ManaguaJuventus Mana |
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| 23 Oct 22 | r13 | Deportivo SebacoDeportivo Seb | 2 - 1 | MatagalpaMatagalpa |
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| 27 Oct 22 | r14 | MatagalpaMatagalpa | 1 - 0 | CD OcotalCD Ocotal |
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| 29 Oct 22 | r15 | CD Walter FerretiCD Walter Fer | 1 - 0 | MatagalpaMatagalpa |
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| 23 Nov 22 | r16 | MatagalpaMatagalpa | 3 - 3 | UNAM ManaguaUNAM Managua |
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| 26 Nov 22 | r17 | Managua FCManagua FC | 2 - 1 | MatagalpaMatagalpa |
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| 02 Dec 22 | r18 | Real Estelí FCReal Estelí F | 6 - 0 | MatagalpaMatagalpa |
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| 22 Jan 23 | r01 | MatagalpaMatagalpa | 0 - 3 | DiriangénDiriangén |
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| 30 Jan 23 | r02 | JalapaJalapa | 1 - 1 | MatagalpaMatagalpa |
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| 05 Feb 23 | r03 | MatagalpaMatagalpa | 1 - 0 | Juventus ManaguaJuventus Mana |
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| 09 Feb 23 | r04 | Deportivo SebacoDeportivo Seb | 0 - 3 | MatagalpaMatagalpa |
| |
| 12 Feb 23 | r05 | MatagalpaMatagalpa | 2 - 0 | CD OcotalCD Ocotal |
| |
| 16 Feb 23 | r06 | CD Walter FerretiCD Walter Fer | 0 - 1 | MatagalpaMatagalpa |
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| 19 Feb 23 | r07 | MatagalpaMatagalpa | 3 - 0 | UNAM ManaguaUNAM Managua |
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| 25 Feb 23 | r08 | Managua FCManagua FC | 3 - 0 | MatagalpaMatagalpa |
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| 05 Mar 23 | r09 | Real Estelí FCReal Estelí F | 2 - 1 | MatagalpaMatagalpa |
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| 10 Mar 23 | r10 | DiriangénDiriangén | 2 - 1 | MatagalpaMatagalpa |
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| 19 Mar 23 | r11 | MatagalpaMatagalpa | 1 - 2 | JalapaJalapa |
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| 25 Mar 23 | r12 | Juventus ManaguaJuventus Mana | 2 - 2 | MatagalpaMatagalpa |
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| 01 Apr 23 | r13 | MatagalpaMatagalpa | 0 - 0 | Deportivo SebacoDeportivo Seb |
| |
| 05 Apr 23 | r14 | CD OcotalCD Ocotal | 0 - 1 | MatagalpaMatagalpa |
| |
| 12 Apr 23 | r15 | MatagalpaMatagalpa | 1 - 0 | CD Walter FerretiCD Walter Fer |
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| 15 Apr 23 | r16 | UNAM ManaguaUNAM Managua | 3 - 1 | MatagalpaMatagalpa |
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| 19 Apr 23 | r17 | MatagalpaMatagalpa | 0 - 0 | Managua FCManagua FC |
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| 23 Apr 23 | r18 | MatagalpaMatagalpa | 0 - 1 | Real Estelí FCReal Estelí F |
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| 28 Apr 23 | r00 | CD Walter FerretiCD Walter Fer | 1 - 1 | MatagalpaMatagalpa |
| 30 Apr 23 | r00 | MatagalpaMatagalpa | 0 - 2 | DiriangénDiriangén |
| 07 May 23 | r00 | DiriangénDiriangén | 3 - 0 | MatagalpaMatagalpa |
Team 2022-2023 Schedules
ART Jalapa
Diriangén
Managua
Matagalpa
Rancho Santana
Real Estelí
San Marcos
Sébaco
UNAN Managua
Walter Ferretti
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