| 02 Aug 20 | r01  | Managua FCManagua FC | 2 - 0 | Junior de ManaguaJunior de Man |
| |
| 10 Aug 20 | r02 | CD OcotalCD Ocotal | 5 - 0 | Managua FCManagua FC |
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| 13 Aug 20 | r03 | Managua FCManagua FC | 1 - 0 | ChinandegaChinandega |
| |
| 16 Aug 20 | r04 | Real MadrizReal Madriz | 0 - 2 | Managua FCManagua FC |
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| 23 Aug 20 | r05 | Managua FCManagua FC | 0 - 1 | Juventus ManaguaJuventus Mana |
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| 30 Aug 20 | r06 | JalapaJalapa | 1 - 0 | Managua FCManagua FC |
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| 06 Sep 20 | r07 | Managua FCManagua FC | 1 - 2 | CD Walter FerretiCD Walter Fer |
| |
| 13 Sep 20 | r08 | DiriangénDiriangén | 0 - 0 | Managua FCManagua FC |
| |
| 20 Sep 20 | r09 | Managua FCManagua FC | 3 - 4 | Real Estelí FCReal Estelí F |
| |
| 27 Sep 20 | r10 | Junior de ManaguaJunior de Man | 2 - 2 | Managua FCManagua FC |
| |
| 01 Oct 20 | r11 | Managua FCManagua FC | 2 - 2 | CD OcotalCD Ocotal |
| |
| 26 Oct 20 | r13 | Managua FCManagua FC | 0 - 1 | Real MadrizReal Madriz |
| |
| 29 Oct 20 | r14 | Juventus ManaguaJuventus Mana | 2 - 3 | Managua FCManagua FC |
| |
| 01 Nov 20 | r15 | Managua FCManagua FC | 3 - 1 | JalapaJalapa |
| |
| 09 Nov 20 | r16 | CD Walter FerretiCD Walter Fer | 4 - 2 | Managua FCManagua FC |
| |
| 11 Nov 20 | r12 | ChinandegaChinandega | 0 - 0 | Managua FCManagua FC |
| |
| 16 Nov 20 | r17 | Managua FCManagua FC | 3 - 4 | DiriangénDiriangén |
| |
| 20 Nov 20 | r18 | Real Estelí FCReal Estelí F | 1 - 0 | Managua FCManagua FC |
| |
| 24 Jan 21 | r01 | Junior de ManaguaJunior de Man | 1 - 3 | Managua FCManagua FC |
| |
| 27 Jan 21 | r02 | Managua FCManagua FC | 3 - 0 | CD OcotalCD Ocotal |
| |
| 31 Jan 21 | r03 | ChinandegaChinandega | 1 - 1 | Managua FCManagua FC |
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| 03 Feb 21 | r04 | Managua FCManagua FC | 4 - 1 | Real MadrizReal Madriz |
| |
| 07 Feb 21 | r05 | Juventus ManaguaJuventus Mana | 0 - 5 | Managua FCManagua FC |
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| 10 Feb 21 | r06 | Managua FCManagua FC | 5 - 2 | JalapaJalapa |
| |
| 14 Feb 21 | r07 | CD Walter FerretiCD Walter Fer | 2 - 1 | Managua FCManagua FC |
| |
| 18 Feb 21 | r08 | Managua FCManagua FC | 1 - 3 | DiriangénDiriangén |
| |
| 01 Mar 21 | r09 | Real Estelí FCReal Estelí F | 1 - 1 | Managua FCManagua FC |
| |
| 07 Mar 21 | r10 | Managua FCManagua FC | 3 - 1 | Junior de ManaguaJunior de Man |
| |
| 15 Mar 21 | r11 | CD OcotalCD Ocotal | 1 - 0 | Managua FCManagua FC |
| |
| 01 Apr 21 | r12 | Managua FCManagua FC | 3 - 1 | ChinandegaChinandega |
| |
| 15 Apr 21 | r13 | Real MadrizReal Madriz | 1 - 0 | Managua FCManagua FC |
| |
| 19 Apr 21 | r14 | Managua FCManagua FC | 4 - 1 | Juventus ManaguaJuventus Mana |
| |
| 26 Apr 21 | r15 | JalapaJalapa | 2 - 2 | Managua FCManagua FC |
| |
| 29 Apr 21 | r16 | Managua FCManagua FC | 3 - 1 | CD Walter FerretiCD Walter Fer |
| |
| 02 May 21 | r17 | DiriangénDiriangén | 4 - 1 | Managua FCManagua FC |
| |
| 07 May 21 | r18 | Managua FCManagua FC | 1 - 0 | Real Estelí FCReal Estelí F |
| |
| 10 May 21 | r00 | Managua FCManagua FC | 1 - 0 | Real MadrizReal Madriz |
| 14 May 21 | r00 | Managua FCManagua FC | 3 - 1 | Real Estelí FCReal Estelí F |
| 17 May 21 | r00 | Real Estelí FCReal Estelí F | 4 - 2 | Managua FCManagua FC |
| 23 May 21 | r00 | Managua FCManagua FC | 0 - 2 | DiriangénDiriangén |
| 30 May 21 | r00 | DiriangénDiriangén | 1 - 1 | Managua FCManagua FC |
Team 2020-2021 Schedules
ART Jalapa
Diriangén
Managua
Matagalpa
Rancho Santana
Real Estelí
San Marcos
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UNAN Managua
Walter Ferretti
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