| 27 Feb 22 | r01    | Home UnitedHome United | 3 - 1 | Hougang UnitedHougang Unite |
| 04 Mar 22 | r01 | Geylang InternationalGeylang Inter | 1 - 0 | Home UnitedHome United |
| 13 Mar 22 | r01 | Home UnitedHome United | 1 - 0 | Tampines RoversTampines Rove |
| |
| 18 Mar 22 | r02 | Albirex Niigata SAlbirex Niiga | 1 - 1 | Home UnitedHome United |
| 01 Apr 22 | r02 | Home UnitedHome United | 4 - 0 | Balestier KhalsaBalestier Kha |
| |
| 06 Apr 22 | r03 | Young LionsYoung Lions | 0 - 1 | Home UnitedHome United |
| 09 Apr 22 | r03 | Home UnitedHome United | 6 - 1 | Tanjong Pagar UnitedTanjong Pagar |
| |
| 06 May 22 | r04 | Hougang UnitedHougang Unite | 3 - 4 | Home UnitedHome United |
| 14 May 22 | r04 | Home UnitedHome United | 1 - 0 | Geylang InternationalGeylang Inter |
| 21 May 22 | r04 | Tampines RoversTampines Rove | 0 - 4 | Home UnitedHome United |
| |
| 19 Jun 22 | r05 | Balestier KhalsaBalestier Kha | 1 - 6 | Home UnitedHome United |
| 24 Jun 22 | r05 | Home UnitedHome United | 1 - 2 | Albirex Niigata SAlbirex Niiga |
| |
| 29 Jun 22 | r06 | Home UnitedHome United | 5 - 1 | Young LionsYoung Lions |
| 03 Jul 22 | r06 | Tanjong Pagar UnitedTanjong Pagar | 0 - 6 | Home UnitedHome United |
| 09 Jul 22 | r06 | Home UnitedHome United | 1 - 1 | Hougang UnitedHougang Unite |
| |
| 16 Jul 22 | r07 | Geylang InternationalGeylang Inter | 1 - 1 | Home UnitedHome United |
| 24 Jul 22 | r07 | Home UnitedHome United | 2 - 1 | Tampines RoversTampines Rove |
| 29 Jul 22 | r07 | Albirex Niigata SAlbirex Niiga | 4 - 2 | Home UnitedHome United |
| |
| 06 Aug 22 | r08 | Home UnitedHome United | 4 - 0 | Balestier KhalsaBalestier Kha |
| 13 Aug 22 | r08 | Young LionsYoung Lions | 1 - 10 | Home UnitedHome United |
| |
| 20 Aug 22 | r09 | Home UnitedHome United | 7 - 0 | Tanjong Pagar UnitedTanjong Pagar |
| 26 Aug 22 | r09 | Hougang UnitedHougang Unite | 4 - 9 | Home UnitedHome United |
| |
| 04 Sep 22 | r10 | Home UnitedHome United | 1 - 3 | Geylang InternationalGeylang Inter |
| 10 Sep 22 | r10 | Tampines RoversTampines Rove | 2 - 1 | Home UnitedHome United |
| |
| 02 Oct 22 | r11 | Balestier KhalsaBalestier Kha | 5 - 3 | Home UnitedHome United |
| 07 Oct 22 | r11 | Home UnitedHome United | 2 - 4 | Albirex Niigata SAlbirex Niiga |
| 14 Oct 22 | r11 | Tanjong Pagar UnitedTanjong Pagar | 1 - 3 | Home UnitedHome United |
| |
| 21 Oct 22 | r10 | Home UnitedHome United | 2 - 1 | Young LionsYoung Lions |
Team 2022 Schedules
Albirex Niigata S
Balestier Khalsa
Geylang International
Hougang United
Lion City Sailors
Tampines Rovers
Tanjong Pagar United
Young Lions
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