| 19 Sep 21 | r01  | FBC GravinaFBC Gravina | 1 - 2 | CasaranoCasarano |
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| 26 Sep 21 | r02 | ASD Team AltamuraASD Team Alta | 0 - 1 | FBC GravinaFBC Gravina |
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| 03 Oct 21 | r03 | FBC GravinaFBC Gravina | 1 - 0 | BisceglieBisceglie |
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| 06 Oct 21 | r04 | FBC GravinaFBC Gravina | 1 - 0 | A.C.D. NardòA.C.D. Nardò |
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| 10 Oct 21 | r05 | NocerinaNocerina | 2 - 1 | FBC GravinaFBC Gravina |
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| 17 Oct 21 | r06 | FBC GravinaFBC Gravina | 0 - 1 | S.S.D. Audace CerignolaS.S.D. Audace |
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| 20 Oct 21 | r07 | CasertanaCasertana | 5 - 1 | FBC GravinaFBC Gravina |
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| 24 Oct 21 | r08 | FBC GravinaFBC Gravina | 0 - 2 | Virtus MatinoVirtus Matino |
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| 31 Oct 21 | r09 | LavelloLavello | 3 - 3 | FBC GravinaFBC Gravina |
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| 07 Nov 21 | r10 | FBC GravinaFBC Gravina | 3 - 0 | U.S. BitontoU.S. Bitonto |
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| 14 Nov 21 | r11 | MariglianeseMariglianese | 1 - 2 | FBC GravinaFBC Gravina |
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| 21 Nov 21 | r12 | FBC GravinaFBC Gravina | 2 - 1 | S.S.D. Città di BrindisiS.S.D. Città |
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| 28 Nov 21 | r13 | F.C. FrancavillaF.C. Francavi | 1 - 0 | FBC GravinaFBC Gravina |
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| 04 Dec 21 | r14 | FBC GravinaFBC Gravina | 2 - 0 | A.S.D. SorrentoA.S.D. Sorren |
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| 08 Dec 21 | r15 | RotondaRotonda | 0 - 1 | FBC GravinaFBC Gravina |
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| 12 Dec 21 | r16 | FBC GravinaFBC Gravina | 0 - 0 | Molfetta CalcioMolfetta Calc |
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| 19 Dec 21 | r17 | San GiorgioSan Giorgio | 1 - 3 | FBC GravinaFBC Gravina |
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| 22 Dec 21 | r18 | FBC GravinaFBC Gravina | 1 - 0 | A.S.D. F.C. S.S. Nola 192A.S.D. F.C. S |
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| 23 Jan 22 | r19 | U.S.D. Città di FasanoU.S.D. Città | 5 - 2 | FBC GravinaFBC Gravina |
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| 29 Jan 22 | r20 | CasaranoCasarano | 1 - 1 | FBC GravinaFBC Gravina |
| 29 Jan 22 | r20 | CasaranoCasarano | 1 - 0 | FBC GravinaFBC Gravina |
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| 02 Feb 22 | r21 | FBC GravinaFBC Gravina | 1 - 0 | ASD Team AltamuraASD Team Alta |
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| 06 Feb 22 | r22 | BisceglieBisceglie | 2 - 3 | FBC GravinaFBC Gravina |
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| 13 Feb 22 | r23 | A.C.D. NardòA.C.D. Nardò | 2 - 3 | FBC GravinaFBC Gravina |
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| 16 Feb 22 | r24 | FBC GravinaFBC Gravina | 0 - 2 | NocerinaNocerina |
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| 20 Feb 22 | r25 | S.S.D. Audace CerignolaS.S.D. Audace | 2 - 1 | FBC GravinaFBC Gravina |
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| 27 Feb 22 | r26 | FBC GravinaFBC Gravina | 0 - 1 | CasertanaCasertana |
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| 13 Mar 22 | r28 | FBC GravinaFBC Gravina | 2 - 0 | LavelloLavello |
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| 18 Mar 22 | r27 | Virtus MatinoVirtus Matino | 3 - 2 | FBC GravinaFBC Gravina |
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| 27 Mar 22 | r29 | U.S. BitontoU.S. Bitonto | 2 - 2 | FBC GravinaFBC Gravina |
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| 30 Mar 22 | r30 | FBC GravinaFBC Gravina | 0 - 0 | MariglianeseMariglianese |
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| 03 Apr 22 | r31 | S.S.D. Città di BrindisiS.S.D. Città | 1 - 0 | FBC GravinaFBC Gravina |
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| 10 Apr 22 | r32 | FBC GravinaFBC Gravina | 3 - 2 | F.C. FrancavillaF.C. Francavi |
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| 14 Apr 22 | r33 | A.S.D. SorrentoA.S.D. Sorren | 2 - 2 | FBC GravinaFBC Gravina |
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| 24 Apr 22 | r34 | FBC GravinaFBC Gravina | 0 - 1 | RotondaRotonda |
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| 01 May 22 | r35 | Molfetta CalcioMolfetta Calc | 1 - 1 | FBC GravinaFBC Gravina |
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| 08 May 22 | r36 | FBC GravinaFBC Gravina | 1 - 1 | San GiorgioSan Giorgio |
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| 15 May 22 | r37 | A.S.D. F.C. S.S. Nola 192A.S.D. F.C. S | 1 - 0 | FBC GravinaFBC Gravina |
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| 22 May 22 | r38 | FBC GravinaFBC Gravina | 4 - 1 | U.S.D. Città di FasanoU.S.D. Città |
Team 2021-2022 Schedules
Afragolese
Barletta
Città di Fasano
Ferrandina
Fidelis Andria
Francavilla
Gravina
Heraclea
Manfredonia
Martina
Nardò
Nola
Paganese
Pompei
Real Acerrana
Real Normanna
Sarnese
Virtus Francavilla
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