| 26 Mar 21 | r01        | Galway UnitedGalway United | 0 - 0 | Shelbourne FCShelbourne FC |
| 26 Mar 21 | r01        | Cork City FCCork City FC | 2 - 1 | Cobh RamblersCobh Ramblers |
| 26 Mar 21 | r01        | UCDUCD | 2 - 2 | Athlone TownAthlone Town |
| 26 Mar 21 | r01        | WexfordWexford | 1 - 2 | CabinteelyCabinteely |
| 28 Mar 21 | r01        | Bray WanderersBray Wanderer | 0 - 0 | Treaty UnitedTreaty United |
| |
| 02 Apr 21 | r02        | CabinteelyCabinteely | 1 - 0 | Cork City FCCork City FC |
| 02 Apr 21 | r02        | Shelbourne FCShelbourne FC | 3 - 3 | Bray WanderersBray Wanderer |
| 02 Apr 21 | r02        | Treaty UnitedTreaty United | 1 - 0 | WexfordWexford |
| 02 Apr 21 | r02        | Athlone TownAthlone Town | 3 - 1 | Galway UnitedGalway United |
| 03 Apr 21 | r02        | Cobh RamblersCobh Ramblers | 0 - 4 | UCDUCD |
| |
| 09 Apr 21 | r03        | Treaty UnitedTreaty United | 1 - 1 | Cobh RamblersCobh Ramblers |
| 09 Apr 21 | r03        | Shelbourne FCShelbourne FC | 1 - 0 | WexfordWexford |
| 09 Apr 21 | r03        | UCDUCD | 0 - 0 | Bray WanderersBray Wanderer |
| 09 Apr 21 | r03        | Cork City FCCork City FC | 0 - 1 | Athlone TownAthlone Town |
| 09 Apr 21 | r03        | CabinteelyCabinteely | 0 - 3 | Galway UnitedGalway United |
| |
| 16 Apr 21 | r04        | Bray WanderersBray Wanderer | 1 - 2 | Athlone TownAthlone Town |
| 16 Apr 21 | r04        | UCDUCD | 4 - 1 | CabinteelyCabinteely |
| 16 Apr 21 | r04        | Cork City FCCork City FC | 1 - 3 | Shelbourne FCShelbourne FC |
| 16 Apr 21 | r04        | WexfordWexford | 1 - 2 | Cobh RamblersCobh Ramblers |
| 16 Apr 21 | r04        | Galway UnitedGalway United | 1 - 1 | Treaty UnitedTreaty United |
| |
| 23 Apr 21 | r05        | Galway UnitedGalway United | 2 - 2 | UCDUCD |
| 23 Apr 21 | r05        | CabinteelyCabinteely | 1 - 3 | Shelbourne FCShelbourne FC |
| 23 Apr 21 | r05        | Athlone TownAthlone Town | 3 - 0 | WexfordWexford |
| 23 Apr 21 | r05        | Treaty UnitedTreaty United | 2 - 1 | Cork City FCCork City FC |
| 24 Apr 21 | r05        | Cobh RamblersCobh Ramblers | 1 - 1 | Bray WanderersBray Wanderer |
| |
| 30 Apr 21 | r06        | Bray WanderersBray Wanderer | 0 - 0 | Cork City FCCork City FC |
| 30 Apr 21 | r06        | Shelbourne FCShelbourne FC | 2 - 2 | Treaty UnitedTreaty United |
| 30 Apr 21 | r06        | WexfordWexford | 0 - 6 | UCDUCD |
| 30 Apr 21 | r06        | Athlone TownAthlone Town | 1 - 2 | CabinteelyCabinteely |
| 01 May 21 | r06        | Cobh RamblersCobh Ramblers | 0 - 4 | Galway UnitedGalway United |
| |
| 07 May 21 | r07        | Cork City FCCork City FC | 5 - 0 | WexfordWexford |
| 07 May 21 | r07        | Shelbourne FCShelbourne FC | 1 - 0 | Athlone TownAthlone Town |
| 07 May 21 | r07        | CabinteelyCabinteely | 1 - 0 | Cobh RamblersCobh Ramblers |
| 07 May 21 | r07        | Galway UnitedGalway United | 1 - 2 | Bray WanderersBray Wanderer |
| 07 May 21 | r07        | UCDUCD | 3 - 2 | Treaty UnitedTreaty United |
| |
| 14 May 21 | r08        | Bray WanderersBray Wanderer | 3 - 0 | CabinteelyCabinteely |
| 14 May 21 | r08        | UCDUCD | 0 - 0 | Cork City FCCork City FC |
| 14 May 21 | r08        | Galway UnitedGalway United | 1 - 0 | WexfordWexford |
| 14 May 21 | r08        | Treaty UnitedTreaty United | 1 - 0 | Athlone TownAthlone Town |
| 15 May 21 | r08        | Cobh RamblersCobh Ramblers | 1 - 2 | Shelbourne FCShelbourne FC |
| |
| 21 May 21 | r09        | WexfordWexford | 0 - 1 | Bray WanderersBray Wanderer |
| 21 May 21 | r09        | Athlone TownAthlone Town | 2 - 1 | Cobh RamblersCobh Ramblers |
| 21 May 21 | r09        | Cork City FCCork City FC | 1 - 1 | Galway UnitedGalway United |
| 21 May 21 | r09        | Shelbourne FCShelbourne FC | 3 - 1 | UCDUCD |
| 21 May 21 | r09        | CabinteelyCabinteely | 2 - 1 | Treaty UnitedTreaty United |
| |
| 28 May 21 | r10        | Cobh RamblersCobh Ramblers | 1 - 0 | Cork City FCCork City FC |
| 28 May 21 | r10        | Treaty UnitedTreaty United | 2 - 0 | Bray WanderersBray Wanderer |
| 28 May 21 | r10        | Athlone TownAthlone Town | 2 - 3 | UCDUCD |
| 28 May 21 | r10        | Shelbourne FCShelbourne FC | 4 - 0 | Galway UnitedGalway United |
| 28 May 21 | r10        | CabinteelyCabinteely | 0 - 2 | WexfordWexford |
| |
| 11 Jun 21 | r11        | Bray WanderersBray Wanderer | 1 - 4 | Shelbourne FCShelbourne FC |
| 11 Jun 21 | r11        | Cork City FCCork City FC | 0 - 2 | CabinteelyCabinteely |
| 11 Jun 21 | r11        | WexfordWexford | 1 - 2 | Treaty UnitedTreaty United |
| 11 Jun 21 | r11        | Galway UnitedGalway United | 2 - 1 | Athlone TownAthlone Town |
| 11 Jun 21 | r11        | UCDUCD | 1 - 2 | Cobh RamblersCobh Ramblers |
| |
| 18 Jun 21 | r12        | Bray WanderersBray Wanderer | 4 - 0 | UCDUCD |
| 18 Jun 21 | r12        | WexfordWexford | 0 - 1 | Shelbourne FCShelbourne FC |
| 18 Jun 21 | r12        | Athlone TownAthlone Town | 0 - 2 | Cork City FCCork City FC |
| 18 Jun 21 | r12        | Galway UnitedGalway United | 1 - 0 | CabinteelyCabinteely |
| 19 Jun 21 | r12        | Cobh RamblersCobh Ramblers | 0 - 2 | Treaty UnitedTreaty United |
| |
| 25 Jun 21 | r13        | Shelbourne FCShelbourne FC | 2 - 1 | Cork City FCCork City FC |
| 25 Jun 21 | r13        | CabinteelyCabinteely | 1 - 2 | UCDUCD |
| 25 Jun 21 | r13        | Athlone TownAthlone Town | 0 - 0 | Bray WanderersBray Wanderer |
| 25 Jun 21 | r13        | Treaty UnitedTreaty United | 0 - 1 | Galway UnitedGalway United |
| 26 Jun 21 | r13        | Cobh RamblersCobh Ramblers | 3 - 2 | WexfordWexford |
| |
| 02 Jul 21 | r14        | Bray WanderersBray Wanderer | 2 - 1 | Cobh RamblersCobh Ramblers |
| 02 Jul 21 | r14        | UCDUCD | 0 - 2 | Galway UnitedGalway United |
| 02 Jul 21 | r14        | Shelbourne FCShelbourne FC | 1 - 0 | CabinteelyCabinteely |
| 02 Jul 21 | r14        | Cork City FCCork City FC | 2 - 3 | Treaty UnitedTreaty United |
| 02 Jul 21 | r14        | WexfordWexford | 4 - 4 | Athlone TownAthlone Town |
| |
| 09 Jul 21 | r15        | UCDUCD | 2 - 1 | WexfordWexford |
| 09 Jul 21 | r15        | Galway UnitedGalway United | 2 - 0 | Cobh RamblersCobh Ramblers |
| 09 Jul 21 | r15        | Cork City FCCork City FC | 2 - 2 | Bray WanderersBray Wanderer |
| 09 Jul 21 | r15        | CabinteelyCabinteely | 0 - 1 | Athlone TownAthlone Town |
| 09 Jul 21 | r15        | Treaty UnitedTreaty United | 1 - 1 | Shelbourne FCShelbourne FC |
| |
| 16 Jul 21 | r16        | Bray WanderersBray Wanderer | 0 - 0 | Galway UnitedGalway United |
| 16 Jul 21 | r16        | Athlone TownAthlone Town | 1 - 3 | Shelbourne FCShelbourne FC |
| 16 Jul 21 | r16        | Treaty UnitedTreaty United | 2 - 1 | UCDUCD |
| 16 Jul 21 | r16        | WexfordWexford | 0 - 0 | Cork City FCCork City FC |
| 17 Jul 21 | r16        | Cobh RamblersCobh Ramblers | 1 - 0 | CabinteelyCabinteely |
| |
| 30 Jul 21 | r17        | Cork City FCCork City FC | 1 - 1 | UCDUCD |
| 30 Jul 21 | r17        | CabinteelyCabinteely | 0 - 3 | Bray WanderersBray Wanderer |
| 30 Jul 21 | r17        | Shelbourne FCShelbourne FC | 2 - 2 | Cobh RamblersCobh Ramblers |
| 30 Jul 21 | r17        | Athlone TownAthlone Town | 1 - 4 | Treaty UnitedTreaty United |
| 30 Jul 21 | r17        | WexfordWexford | 1 - 3 | Galway UnitedGalway United |
| |
| 06 Aug 21 | r18        | Bray WanderersBray Wanderer | 3 - 1 | WexfordWexford |
| 06 Aug 21 | r18        | UCDUCD | 0 - 0 | Shelbourne FCShelbourne FC |
| 06 Aug 21 | r18        | Galway UnitedGalway United | 2 - 3 | Cork City FCCork City FC |
| 06 Aug 21 | r18        | Treaty UnitedTreaty United | 1 - 4 | CabinteelyCabinteely |
| 07 Aug 21 | r18        | Cobh RamblersCobh Ramblers | 0 - 0 | Athlone TownAthlone Town |
| |
| 13 Aug 21 | r19        | Bray WanderersBray Wanderer | 1 - 0 | Treaty UnitedTreaty United |
| 13 Aug 21 | r19        | UCDUCD | 6 - 0 | Athlone TownAthlone Town |
| 13 Aug 21 | r19        | Galway UnitedGalway United | 3 - 1 | Shelbourne FCShelbourne FC |
| 13 Aug 21 | r19        | Cork City FCCork City FC | 4 - 0 | Cobh RamblersCobh Ramblers |
| 13 Aug 21 | r19        | WexfordWexford | 2 - 1 | CabinteelyCabinteely |
| |
| 20 Aug 21 | r20        | Shelbourne FCShelbourne FC | 1 - 1 | Bray WanderersBray Wanderer |
| 20 Aug 21 | r20        | CabinteelyCabinteely | 2 - 2 | Cork City FCCork City FC |
| 20 Aug 21 | r20        | Athlone TownAthlone Town | 1 - 0 | Galway UnitedGalway United |
| 20 Aug 21 | r20        | Treaty UnitedTreaty United | 1 - 1 | WexfordWexford |
| 21 Aug 21 | r20        | Cobh RamblersCobh Ramblers | 0 - 2 | UCDUCD |
| |
| 03 Sep 21 | r21        | UCDUCD | 4 - 3 | Bray WanderersBray Wanderer |
| 03 Sep 21 | r21        | Shelbourne FCShelbourne FC | 4 - 0 | WexfordWexford |
| 03 Sep 21 | r21        | Cork City FCCork City FC | 3 - 1 | Athlone TownAthlone Town |
| 03 Sep 21 | r21        | CabinteelyCabinteely | 0 - 1 | Galway UnitedGalway United |
| 03 Sep 21 | r21        | Treaty UnitedTreaty United | 3 - 0 | Cobh RamblersCobh Ramblers |
| |
| 10 Sep 21 | r22        | Bray WanderersBray Wanderer | 0 - 1 | Athlone TownAthlone Town |
| 10 Sep 21 | r22        | UCDUCD | 5 - 2 | CabinteelyCabinteely |
| 10 Sep 21 | r22        | Cork City FCCork City FC | 0 - 2 | Shelbourne FCShelbourne FC |
| 10 Sep 21 | r22        | Galway UnitedGalway United | 0 - 0 | Treaty UnitedTreaty United |
| 10 Sep 21 | r22        | WexfordWexford | 3 - 1 | Cobh RamblersCobh Ramblers |
| |
| 24 Sep 21 | r23        | CabinteelyCabinteely | 0 - 2 | Shelbourne FCShelbourne FC |
| 24 Sep 21 | r23        | Athlone TownAthlone Town | 0 - 2 | WexfordWexford |
| 24 Sep 21 | r23        | Galway UnitedGalway United | 4 - 1 | UCDUCD |
| 24 Sep 21 | r23        | Treaty UnitedTreaty United | 0 - 0 | Cork City FCCork City FC |
| 25 Sep 21 | r23        | Cobh RamblersCobh Ramblers | 1 - 2 | Bray WanderersBray Wanderer |
| |
| 01 Oct 21 | r24        | Bray WanderersBray Wanderer | 0 - 0 | Cork City FCCork City FC |
| 01 Oct 21 | r24        | Athlone TownAthlone Town | 2 - 1 | CabinteelyCabinteely |
| 01 Oct 21 | r24        | Shelbourne FCShelbourne FC | 1 - 0 | Treaty UnitedTreaty United |
| 01 Oct 21 | r24        | WexfordWexford | 2 - 1 | UCDUCD |
| 01 Oct 21 | r24        | Cobh RamblersCobh Ramblers | 0 - 1 | Galway UnitedGalway United |
| |
| 08 Oct 21 | r25        | UCDUCD | - | Treaty UnitedTreaty United |
| 08 Oct 21 | r25        | Shelbourne FCShelbourne FC | 1 - 1 | Athlone TownAthlone Town |
| 08 Oct 21 | r25        | Cork City FCCork City FC | 4 - 0 | WexfordWexford |
| 08 Oct 21 | r25        | CabinteelyCabinteely | 1 - 2 | Cobh RamblersCobh Ramblers |
| |
| 15 Oct 21 | r26        | Bray WanderersBray Wanderer | 1 - 2 | CabinteelyCabinteely |
| 15 Oct 21 | r26        | Galway UnitedGalway United | 2 - 1 | WexfordWexford |
| 15 Oct 21 | r26        | Cobh RamblersCobh Ramblers | 2 - 0 | Shelbourne FCShelbourne FC |
| 15 Oct 21 | r26        | UCDUCD | 1 - 0 | Cork City FCCork City FC |
| 15 Oct 21 | r26        | Treaty UnitedTreaty United | 1 - 1 | Athlone TownAthlone Town |
| |
| 22 Oct 21 | r25        | Galway UnitedGalway United | 1 - 0 | Bray WanderersBray Wanderer |
| 22 Oct 21 | r25        | Galway UnitedGalway United | 1 - 0 | Bray WanderersBray Wanderer |
| 22 Oct 21 | r25        | UCDUCD | 2 - 1 | Treaty UnitedTreaty United |
| |
| 29 Oct 21 | r27        | WexfordWexford | 4 - 2 | Bray WanderersBray Wanderer |
| 29 Oct 21 | r27        | Shelbourne FCShelbourne FC | 1 - 1 | UCDUCD |
| 29 Oct 21 | r27        | Cork City FCCork City FC | 3 - 0 | Galway UnitedGalway United |
| 29 Oct 21 | r27        | Athlone TownAthlone Town | 1 - 2 | Cobh RamblersCobh Ramblers |
| 29 Oct 21 | r27        | CabinteelyCabinteely | 0 - 2 | Treaty UnitedTreaty United |
| |
| 03 Nov 21 | r00        | Bray WanderersBray Wanderer | 0 - 0 | Galway UnitedGalway United |
| 03 Nov 21 | r00        | Treaty UnitedTreaty United | 0 - 3 | UCDUCD |
| 07 Nov 21 | r00        | Galway UnitedGalway United | 0 - 1 | Bray WanderersBray Wanderer |
| 07 Nov 21 | r00        | UCDUCD | 1 - 2 | Treaty UnitedTreaty United |
| 19 Nov 21 | r00        | Bray WanderersBray Wanderer | 0 - 2 | UCDUCD |