| 07 Aug 21 | r01  | DergviewDergview | 5 - 0 | InstituteInstitute |
| |
| 10 Aug 21 | r02 | InstituteInstitute | 1 - 3 | Ballyclare ComradesBallyclare Co |
| |
| 14 Aug 21 | r03 | Newry City AFCNewry City AF | 5 - 1 | InstituteInstitute |
| |
| 21 Aug 21 | r04 | InstituteInstitute | 0 - 2 | Annagh UnitedAnnagh United |
| |
| 28 Aug 21 | r05 | LoughgallLoughgall | 0 - 2 | InstituteInstitute |
| |
| 04 Sep 21 | r06 | InstituteInstitute | 2 - 1 | DundelaDundela |
| |
| 11 Sep 21 | r26 | InstituteInstitute | 0 - 1 | H and W WeldersH and W Welde |
| |
| 18 Sep 21 | r08 | InstituteInstitute | 2 - 1 | ArdsArds |
| |
| 25 Sep 21 | r09 | Queens UniversityQueens Univer | 0 - 1 | InstituteInstitute |
| |
| 02 Oct 21 | r10 | InstituteInstitute | 1 - 3 | KnockbredaKnockbreda |
| |
| 09 Oct 21 | r11 | Ballinamallard UnitedBallinamallar | 0 - 0 | InstituteInstitute |
| |
| 16 Oct 21 | r12 | InstituteInstitute | 1 - 2 | Newry City AFCNewry City AF |
| |
| 23 Oct 21 | r13 | Ballyclare ComradesBallyclare Co | 0 - 0 | InstituteInstitute |
| |
| 30 Oct 21 | r14 | Annagh UnitedAnnagh United | 2 - 2 | InstituteInstitute |
| |
| 06 Nov 21 | r15 | InstituteInstitute | 1 - 1 | DergviewDergview |
| |
| 13 Nov 21 | r16 | H and W WeldersH and W Welde | 2 - 0 | InstituteInstitute |
| |
| 20 Nov 21 | r17 | InstituteInstitute | 0 - 2 | LoughgallLoughgall |
| |
| 27 Nov 21 | r18 | InstituteInstitute | 0 - 3 | ArdsArds |
| |
| 04 Dec 21 | r19 | KnockbredaKnockbreda | 2 - 2 | InstituteInstitute |
| |
| 11 Dec 21 | r20 | InstituteInstitute | 0 - 3 | DundelaDundela |
| |
| 18 Dec 21 | r21 | InstituteInstitute | 1 - 2 | Ballinamallard UnitedBallinamallar |
| |
| 27 Dec 21 | r22 | Queens UniversityQueens Univer | 0 - 1 | InstituteInstitute |
| |
| 01 Jan 22 | r23 | InstituteInstitute | 0 - 0 | Newry City AFCNewry City AF |
| |
| 15 Jan 22 | r24 | Ballyclare ComradesBallyclare Co | 1 - 2 | InstituteInstitute |
| |
| 22 Jan 22 | r25 | DergviewDergview | 3 - 1 | InstituteInstitute |
| |
| 29 Jan 22 | r07 | H and W WeldersH and W Welde | 2 - 1 | InstituteInstitute |
| |
| 12 Feb 22 | r27 | InstituteInstitute | 2 - 3 | LoughgallLoughgall |
| |
| 18 Feb 22 | r28 | ArdsArds | 1 - 1 | InstituteInstitute |
| |
| 26 Feb 22 | r29 | InstituteInstitute | 2 - 1 | Ballinamallard UnitedBallinamallar |
| |
| 05 Mar 22 | r30 | DundelaDundela | 4 - 0 | InstituteInstitute |
| |
| 12 Mar 22 | r31 | InstituteInstitute | 0 - 1 | Queens UniversityQueens Univer |
| |
| 19 Mar 22 | r32 | InstituteInstitute | 5 - 1 | Annagh UnitedAnnagh United |
| |
| 26 Mar 22 | r33 | KnockbredaKnockbreda | 2 - 3 | InstituteInstitute |
| |
| 09 Apr 22 | r01 | InstituteInstitute | 2 - 1 | Ballyclare ComradesBallyclare Co |
| |
| 16 Apr 22 | r02 | InstituteInstitute | 3 - 2 | Queens UniversityQueens Univer |
| |
| 19 Apr 22 | r03 | ArdsArds | 0 - 1 | InstituteInstitute |
| |
| 23 Apr 22 | r04 | DundelaDundela | 4 - 1 | InstituteInstitute |
| |
| 30 Apr 22 | r05 | InstituteInstitute | 2 - 1 | KnockbredaKnockbreda |
Team 2021-2022 Schedules
Annagh United
Ards
Armagh City
Ballinamallard United
Dundela
Glenavon
Harland and Wolff Welders
Institute
Loughgall
Moyola Park
Newington
Newry City
Queen's University Belfast
Rathfriland Rangers
Strabane Athletic
Warrenpoint Town
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