| 09 Sep 22 | r06        | Astoria WalldorfAstoria Walld | 3 - 1 | SGV FreibergSGV Freiberg |
| 09 Sep 22 | r06        | FC HomburgFC Homburg | 1 - 3 | Barockstadt Fulda-LehnerzBarockstadt F |
| 09 Sep 22 | r06        | TSV Steinbach HaigerTSV Steinbach | 0 - 3 | Hoffenheim IIHoffenheim II |
| 10 Sep 22 | r06        | SSV UlmSSV Ulm | 2 - 0 | Rot-Weiß KoblenzRot-Weiß Kobl |
| 10 Sep 22 | r06        | Stuttgart IIStuttgart II | 1 - 0 | FSV FrankfurtFSV Frankfurt |
| 10 Sep 22 | r06        | Kickers OffenbachKickers Offen | 3 - 1 | AalenAalen |
| 10 Sep 22 | r06        | Hessen KasselHessen Kassel | 1 - 2 | TSG BalingenTSG Balingen |
| 10 Sep 22 | r06        | Bahlinger SCBahlinger SC | 2 - 0 | Eintracht TrierEintracht Tri |
| 10 Sep 22 | r06        | Mainz IIMainz II | 2 - 3 | Wormatia WormsWormatia Worm |