| 14 Aug 21 | r01        | Hessen KasselHessen Kassel | 1 - 1 | TSV Steinbach HaigerTSV Steinbach |
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| 21 Aug 21 | r02        | Sonnenhof GroßaspachSonnenhof Gro | 4 - 1 | Hessen KasselHessen Kassel |
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| 25 Aug 21 | r03        | Hessen KasselHessen Kassel | 3 - 2 | Stuttgart IIStuttgart II |
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| 28 Aug 21 | r04        | FSV FrankfurtFSV Frankfurt | 1 - 0 | Hessen KasselHessen Kassel |
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| 04 Sep 21 | r05        | Hessen KasselHessen Kassel | 3 - 0 | FC HomburgFC Homburg |
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| 11 Sep 21 | r06        | ElversbergElversberg | 0 - 0 | Hessen KasselHessen Kassel |
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| 14 Sep 21 | r07        | Hessen KasselHessen Kassel | 0 - 0 | Kickers OffenbachKickers Offen |
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| 19 Sep 21 | r08        | SSV UlmSSV Ulm | 2 - 1 | Hessen KasselHessen Kassel |
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| 25 Sep 21 | r09        | Hessen KasselHessen Kassel | 2 - 0 | Rot-Weiß KoblenzRot-Weiß Kobl |
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| 28 Sep 21 | r10        | Hoffenheim IIHoffenheim II | 2 - 0 | Hessen KasselHessen Kassel |
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| 09 Oct 21 | r12        | Hessen KasselHessen Kassel | 0 - 2 | Astoria WalldorfAstoria Walld |
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| 16 Oct 21 | r13        | Mainz IIMainz II | 1 - 3 | Hessen KasselHessen Kassel |
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| 23 Oct 21 | r14        | Hessen KasselHessen Kassel | 2 - 0 | Schott MainzSchott Mainz |
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| 26 Oct 21 | r15        | FK PirmasensFK Pirmasens | 1 - 2 | Hessen KasselHessen Kassel |
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| 30 Oct 21 | r16        | Hessen KasselHessen Kassel | 1 - 1 | Bahlinger SCBahlinger SC |
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| 06 Nov 21 | r17        | TSG BalingenTSG Balingen | 1 - 0 | Hessen KasselHessen Kassel |
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| 13 Nov 21 | r18        | Hessen KasselHessen Kassel | 1 - 2 | AalenAalen |
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| 20 Nov 21 | r19        | FC GießenFC Gießen | 1 - 0 | Hessen KasselHessen Kassel |
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| 26 Nov 21 | r20        | TSV Steinbach HaigerTSV Steinbach | 2 - 2 | Hessen KasselHessen Kassel |
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| 04 Dec 21 | r21        | Hessen KasselHessen Kassel | 4 - 0 | Sonnenhof GroßaspachSonnenhof Gro |
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| 11 Dec 21 | r22        | Stuttgart IIStuttgart II | 1 - 3 | Hessen KasselHessen Kassel |
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| 18 Dec 21 | r23        | Hessen KasselHessen Kassel | 0 - 0 | FSV FrankfurtFSV Frankfurt |
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| 12 Feb 22 | r24        | FC HomburgFC Homburg | 1 - 1 | Hessen KasselHessen Kassel |
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| 19 Feb 22 | r25        | Hessen KasselHessen Kassel | 0 - 2 | ElversbergElversberg |
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| 27 Feb 22 | r26        | Kickers OffenbachKickers Offen | 0 - 1 | Hessen KasselHessen Kassel |
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| 05 Mar 22 | r27        | Hessen KasselHessen Kassel | 0 - 0 | SSV UlmSSV Ulm |
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| 13 Mar 22 | r28        | Rot-Weiß KoblenzRot-Weiß Kobl | 2 - 2 | Hessen KasselHessen Kassel |
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| 20 Mar 22 | r29        | Hessen KasselHessen Kassel | 0 - 0 | Hoffenheim IIHoffenheim II |
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| 02 Apr 22 | r31        | Astoria WalldorfAstoria Walld | 0 - 0 | Hessen KasselHessen Kassel |
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| 06 Apr 22 | r32        | Hessen KasselHessen Kassel | 2 - 1 | Mainz IIMainz II |
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| 09 Apr 22 | r33        | Schott MainzSchott Mainz | 2 - 1 | Hessen KasselHessen Kassel |
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| 16 Apr 22 | r34        | Hessen KasselHessen Kassel | 0 - 3 | FK PirmasensFK Pirmasens |
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| 23 Apr 22 | r35        | Bahlinger SCBahlinger SC | 2 - 3 | Hessen KasselHessen Kassel |
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| 30 Apr 22 | r36        | Hessen KasselHessen Kassel | 4 - 0 | TSG BalingenTSG Balingen |
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| 07 May 22 | r37        | AalenAalen | 0 - 0 | Hessen KasselHessen Kassel |
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| 14 May 22 | r38        | Hessen KasselHessen Kassel | 3 - 0 | FC GießenFC Gießen |