| 14 Aug 21 | r01        | Astoria WalldorfAstoria Walld | 0 - 1 | FC GießenFC Gießen |
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| 20 Aug 21 | r02        | TSV Steinbach HaigerTSV Steinbach | 0 - 0 | Astoria WalldorfAstoria Walld |
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| 24 Aug 21 | r03        | Astoria WalldorfAstoria Walld | 0 - 3 | Sonnenhof GroßaspachSonnenhof Gro |
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| 29 Aug 21 | r04        | Stuttgart IIStuttgart II | 2 - 3 | Astoria WalldorfAstoria Walld |
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| 03 Sep 21 | r05        | Astoria WalldorfAstoria Walld | 2 - 1 | FSV FrankfurtFSV Frankfurt |
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| 10 Sep 21 | r06        | FC HomburgFC Homburg | 3 - 2 | Astoria WalldorfAstoria Walld |
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| 14 Sep 21 | r07        | Astoria WalldorfAstoria Walld | 0 - 2 | ElversbergElversberg |
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| 19 Sep 21 | r08        | Kickers OffenbachKickers Offen | 2 - 0 | Astoria WalldorfAstoria Walld |
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| 24 Sep 21 | r09        | Astoria WalldorfAstoria Walld | 3 - 3 | SSV UlmSSV Ulm |
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| 28 Sep 21 | r10        | Rot-Weiß KoblenzRot-Weiß Kobl | 2 - 2 | Astoria WalldorfAstoria Walld |
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| 02 Oct 21 | r11        | Astoria WalldorfAstoria Walld | 2 - 5 | Hoffenheim IIHoffenheim II |
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| 09 Oct 21 | r12        | Hessen KasselHessen Kassel | 0 - 2 | Astoria WalldorfAstoria Walld |
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| 23 Oct 21 | r14        | Astoria WalldorfAstoria Walld | 0 - 2 | Mainz IIMainz II |
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| 26 Oct 21 | r15        | Schott MainzSchott Mainz | 3 - 1 | Astoria WalldorfAstoria Walld |
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| 30 Oct 21 | r16        | Astoria WalldorfAstoria Walld | 3 - 1 | FK PirmasensFK Pirmasens |
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| 06 Nov 21 | r17        | Bahlinger SCBahlinger SC | 0 - 4 | Astoria WalldorfAstoria Walld |
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| 12 Nov 21 | r18        | Astoria WalldorfAstoria Walld | 0 - 4 | TSG BalingenTSG Balingen |
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| 20 Nov 21 | r19        | AalenAalen | 1 - 4 | Astoria WalldorfAstoria Walld |
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| 27 Nov 21 | r20        | FC GießenFC Gießen | 1 - 1 | Astoria WalldorfAstoria Walld |
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| 03 Dec 21 | r21        | Astoria WalldorfAstoria Walld | 0 - 4 | TSV Steinbach HaigerTSV Steinbach |
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| 11 Dec 21 | r22        | Sonnenhof GroßaspachSonnenhof Gro | 0 - 4 | Astoria WalldorfAstoria Walld |
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| 17 Dec 21 | r23        | Astoria WalldorfAstoria Walld | 1 - 1 | Stuttgart IIStuttgart II |
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| 12 Feb 22 | r24        | FSV FrankfurtFSV Frankfurt | 0 - 0 | Astoria WalldorfAstoria Walld |
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| 18 Feb 22 | r25        | Astoria WalldorfAstoria Walld | 3 - 1 | FC HomburgFC Homburg |
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| 26 Feb 22 | r26        | ElversbergElversberg | 0 - 0 | Astoria WalldorfAstoria Walld |
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| 06 Mar 22 | r27        | Astoria WalldorfAstoria Walld | 1 - 2 | Kickers OffenbachKickers Offen |
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| 18 Mar 22 | r29        | Astoria WalldorfAstoria Walld | 2 - 1 | Rot-Weiß KoblenzRot-Weiß Kobl |
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| 22 Mar 22 | r28        | SSV UlmSSV Ulm | 1 - 0 | Astoria WalldorfAstoria Walld |
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| 26 Mar 22 | r30        | Hoffenheim IIHoffenheim II | 1 - 0 | Astoria WalldorfAstoria Walld |
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| 02 Apr 22 | r31        | Astoria WalldorfAstoria Walld | 0 - 0 | Hessen KasselHessen Kassel |
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| 10 Apr 22 | r33        | Mainz IIMainz II | 6 - 0 | Astoria WalldorfAstoria Walld |
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| 16 Apr 22 | r34        | Astoria WalldorfAstoria Walld | 3 - 1 | Schott MainzSchott Mainz |
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| 23 Apr 22 | r35        | FK PirmasensFK Pirmasens | 1 - 2 | Astoria WalldorfAstoria Walld |
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| 29 Apr 22 | r36        | Astoria WalldorfAstoria Walld | 2 - 1 | Bahlinger SCBahlinger SC |
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| 07 May 22 | r37        | TSG BalingenTSG Balingen | 3 - 2 | Astoria WalldorfAstoria Walld |
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| 14 May 22 | r38        | Astoria WalldorfAstoria Walld | 0 - 2 | AalenAalen |