| 03 Apr 21 | r30        | Sonnenhof GroßaspachSonnenhof Gro | 1 - 1 | FC GießenFC Gießen |
| 03 Apr 21 | r30        | TSV Steinbach HaigerTSV Steinbach | 1 - 1 | FK PirmasensFK Pirmasens |
| 03 Apr 21 | r30        | Bahlinger SCBahlinger SC | 1 - 0 | Stuttgart IIStuttgart II |
| 03 Apr 21 | r30        | Kickers OffenbachKickers Offen | 1 - 0 | SSV UlmSSV Ulm |
| 03 Apr 21 | r30        | Hoffenheim IIHoffenheim II | 4 - 2 | Bayern AlzenauBayern Alzena |
| 03 Apr 21 | r30        | TSG BalingenTSG Balingen | 0 - 1 | Freiburg IIFreiburg II |
| 03 Apr 21 | r30        | Rot-Weiß KoblenzRot-Weiß Kobl | 1 - 1 | ElversbergElversberg |
| 03 Apr 21 | r30        | FSV FrankfurtFSV Frankfurt | 0 - 0 | FC HomburgFC Homburg |
| 03 Apr 21 | r30        | Astoria WalldorfAstoria Walld | 1 - 2 | Hessen KasselHessen Kassel |
| 03 Apr 21 | r30        | AalenAalen | 2 - 1 | Eintracht StadtallendorfEintracht Sta |
| 04 Apr 21 | r30        | Mainz IIMainz II | 3 - 1 | Schott MainzSchott Mainz |